Global variation in bacterial strains that cause tuberculosis disease: a systematic review and meta-analysis

• Published in: BMC medicine Vol. 16; no. 1; pp. 196 - 13
• Main Authors: Wiens, Kirsten E, Woyczynski, Lauren P, Ledesma, Jorge R, Ross, Jennifer M, Zenteno-Cuevas, Roberto, Goodridge, Amador, Ullah, Irfan, Mathema, Barun, Djoba Siawaya, Joel Fleury, Biehl, Molly H, Ray, Sarah E, Bhattacharjee, Natalia V, Henry, Nathaniel J, Reiner, Jr, Robert C, Kyu, Hmwe H, Murray, Christopher J L, Hay, Simon I
• Format: Journal Article
• Language: English
• Published: England BioMed Central 30.10.2018; BMC
• Subjects: Bacteria; Chains; Data collection; Disease transmission; Drug resistance; Environmental factors; Epidemiology; Evidence-based medicine; Failure analysis; Genetic variation; Genotype; Genotypes; Health services; Heterogeneity; Literature reviews; Meta-analysis; Microorganisms; Molecular epidemiology; Mycobacterium tuberculosis; Reviews; Risk management; Sampling methods; Strains (organisms); Systematic review; Tuberculosis; Variation; Beijing China; China; Molecular epidemiology; Genotype; Tuberculosis; Mycobacterium tuberculosis; Genetic variation; Epidemiology

The host, microbial, and environmental factors that contribute to variation in tuberculosis (TB) disease are incompletely understood. Accumulating evidence suggests that one driver of geographic variation in TB disease is the local ecology of mycobacterial genotypes or strains, and there is a need f...