Global variation in bacterial strains that cause tuberculosis disease: a systematic review and meta-analysis

The host, microbial, and environmental factors that contribute to variation in tuberculosis (TB) disease are incompletely understood. Accumulating evidence suggests that one driver of geographic variation in TB disease is the local ecology of mycobacterial genotypes or strains, and there is a need f...

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Published inBMC medicine Vol. 16; no. 1; pp. 196 - 13
Main Authors Wiens, Kirsten E, Woyczynski, Lauren P, Ledesma, Jorge R, Ross, Jennifer M, Zenteno-Cuevas, Roberto, Goodridge, Amador, Ullah, Irfan, Mathema, Barun, Djoba Siawaya, Joel Fleury, Biehl, Molly H, Ray, Sarah E, Bhattacharjee, Natalia V, Henry, Nathaniel J, Reiner, Jr, Robert C, Kyu, Hmwe H, Murray, Christopher J L, Hay, Simon I
Format Journal Article
LanguageEnglish
Published England BioMed Central 30.10.2018
BMC
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Abstract The host, microbial, and environmental factors that contribute to variation in tuberculosis (TB) disease are incompletely understood. Accumulating evidence suggests that one driver of geographic variation in TB disease is the local ecology of mycobacterial genotypes or strains, and there is a need for a comprehensive and systematic synthesis of these data. The objectives of this study were to (1) map the global distribution of genotypes that cause TB disease and (2) examine whether any epidemiologically relevant clinical characteristics were associated with those genotypes. We performed a systematic review of PubMed and Scopus to create a comprehensive dataset of human TB molecular epidemiology studies that used representative sampling techniques. The methods were developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We extracted and synthesized data from studies that reported prevalence of bacterial genotypes and from studies that reported clinical characteristics associated with those genotypes. The results of this study are twofold. First, we identified 206 studies for inclusion in the study, representing over 200,000 bacterial isolates collected over 27 years in 85 countries. We mapped the genotypes and found that, consistent with previously published maps, Euro-American lineage 4 and East Asian lineage 2 strains are widespread, and West African lineages 5 and 6 strains are geographically restricted. Second, 30 studies also reported transmission chains and 4 reported treatment failure associated with genotypes. We performed a meta-analysis and found substantial heterogeneity across studies. However, based on the data available, we found that lineage 2 strains may be associated with increased risk of transmission chains, while lineages 5 and 6 strains may be associated with reduced risk, compared with lineage 4 strains. This study provides the most comprehensive systematic analysis of the evidence for diversity in bacterial strains that cause TB disease. The results show both geographic and epidemiological differences between strains, which could inform our understanding of the global burden of TB. Our findings also highlight the challenges of collecting the clinical data required to inform TB diagnosis and treatment. We urge future national TB programs and research efforts to prioritize and reinforce clinical data collection in study designs and results dissemination.
AbstractList The host, microbial, and environmental factors that contribute to variation in tuberculosis (TB) disease are incompletely understood. Accumulating evidence suggests that one driver of geographic variation in TB disease is the local ecology of mycobacterial genotypes or strains, and there is a need for a comprehensive and systematic synthesis of these data. The objectives of this study were to (1) map the global distribution of genotypes that cause TB disease and (2) examine whether any epidemiologically relevant clinical characteristics were associated with those genotypes. We performed a systematic review of PubMed and Scopus to create a comprehensive dataset of human TB molecular epidemiology studies that used representative sampling techniques. The methods were developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We extracted and synthesized data from studies that reported prevalence of bacterial genotypes and from studies that reported clinical characteristics associated with those genotypes. The results of this study are twofold. First, we identified 206 studies for inclusion in the study, representing over 200,000 bacterial isolates collected over 27 years in 85 countries. We mapped the genotypes and found that, consistent with previously published maps, Euro-American lineage 4 and East Asian lineage 2 strains are widespread, and West African lineages 5 and 6 strains are geographically restricted. Second, 30 studies also reported transmission chains and 4 reported treatment failure associated with genotypes. We performed a meta-analysis and found substantial heterogeneity across studies. However, based on the data available, we found that lineage 2 strains may be associated with increased risk of transmission chains, while lineages 5 and 6 strains may be associated with reduced risk, compared with lineage 4 strains. This study provides the most comprehensive systematic analysis of the evidence for diversity in bacterial strains that cause TB disease. The results show both geographic and epidemiological differences between strains, which could inform our understanding of the global burden of TB. Our findings also highlight the challenges of collecting the clinical data required to inform TB diagnosis and treatment. We urge future national TB programs and research efforts to prioritize and reinforce clinical data collection in study designs and results dissemination.
Abstract Background The host, microbial, and environmental factors that contribute to variation in tuberculosis (TB) disease are incompletely understood. Accumulating evidence suggests that one driver of geographic variation in TB disease is the local ecology of mycobacterial genotypes or strains, and there is a need for a comprehensive and systematic synthesis of these data. The objectives of this study were to (1) map the global distribution of genotypes that cause TB disease and (2) examine whether any epidemiologically relevant clinical characteristics were associated with those genotypes. Methods We performed a systematic review of PubMed and Scopus to create a comprehensive dataset of human TB molecular epidemiology studies that used representative sampling techniques. The methods were developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We extracted and synthesized data from studies that reported prevalence of bacterial genotypes and from studies that reported clinical characteristics associated with those genotypes. Results The results of this study are twofold. First, we identified 206 studies for inclusion in the study, representing over 200,000 bacterial isolates collected over 27 years in 85 countries. We mapped the genotypes and found that, consistent with previously published maps, Euro-American lineage 4 and East Asian lineage 2 strains are widespread, and West African lineages 5 and 6 strains are geographically restricted. Second, 30 studies also reported transmission chains and 4 reported treatment failure associated with genotypes. We performed a meta-analysis and found substantial heterogeneity across studies. However, based on the data available, we found that lineage 2 strains may be associated with increased risk of transmission chains, while lineages 5 and 6 strains may be associated with reduced risk, compared with lineage 4 strains. Conclusions This study provides the most comprehensive systematic analysis of the evidence for diversity in bacterial strains that cause TB disease. The results show both geographic and epidemiological differences between strains, which could inform our understanding of the global burden of TB. Our findings also highlight the challenges of collecting the clinical data required to inform TB diagnosis and treatment. We urge future national TB programs and research efforts to prioritize and reinforce clinical data collection in study designs and results dissemination.
Background The host, microbial, and environmental factors that contribute to variation in tuberculosis (TB) disease are incompletely understood. Accumulating evidence suggests that one driver of geographic variation in TB disease is the local ecology of mycobacterial genotypes or strains, and there is a need for a comprehensive and systematic synthesis of these data. The objectives of this study were to (1) map the global distribution of genotypes that cause TB disease and (2) examine whether any epidemiologically relevant clinical characteristics were associated with those genotypes. Methods We performed a systematic review of PubMed and Scopus to create a comprehensive dataset of human TB molecular epidemiology studies that used representative sampling techniques. The methods were developed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We extracted and synthesized data from studies that reported prevalence of bacterial genotypes and from studies that reported clinical characteristics associated with those genotypes. Results The results of this study are twofold. First, we identified 206 studies for inclusion in the study, representing over 200,000 bacterial isolates collected over 27 years in 85 countries. We mapped the genotypes and found that, consistent with previously published maps, Euro-American lineage 4 and East Asian lineage 2 strains are widespread, and West African lineages 5 and 6 strains are geographically restricted. Second, 30 studies also reported transmission chains and 4 reported treatment failure associated with genotypes. We performed a meta-analysis and found substantial heterogeneity across studies. However, based on the data available, we found that lineage 2 strains may be associated with increased risk of transmission chains, while lineages 5 and 6 strains may be associated with reduced risk, compared with lineage 4 strains. Conclusions This study provides the most comprehensive systematic analysis of the evidence for diversity in bacterial strains that cause TB disease. The results show both geographic and epidemiological differences between strains, which could inform our understanding of the global burden of TB. Our findings also highlight the challenges of collecting the clinical data required to inform TB diagnosis and treatment. We urge future national TB programs and research efforts to prioritize and reinforce clinical data collection in study designs and results dissemination.
ArticleNumber 196
Author Hay, Simon I
Mathema, Barun
Djoba Siawaya, Joel Fleury
Murray, Christopher J L
Reiner, Jr, Robert C
Bhattacharjee, Natalia V
Wiens, Kirsten E
Zenteno-Cuevas, Roberto
Biehl, Molly H
Ledesma, Jorge R
Woyczynski, Lauren P
Ross, Jennifer M
Ullah, Irfan
Goodridge, Amador
Kyu, Hmwe H
Henry, Nathaniel J
Ray, Sarah E
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  surname: Bhattacharjee
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  surname: Hay
  fullname: Hay, Simon I
  email: sihay@uw.edu
  organization: Institute for Health Metrics and Evaluation, University of Washington, 2301 5th Ave, Suite 600, Seattle, WA, 98121, USA. sihay@uw.edu
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Cites_doi 10.1128/JCM.00430-10
10.1086/656410
10.1111/tan.13070
10.1016/j.tube.2011.06.001
10.1371/journal.pbio.0060311
10.1371/journal.pone.0007815
10.1186/s12916-017-0864-y
10.1371/journal.pmed.1000100
10.1186/1471-2334-13-131
10.1086/650311
10.1371/journal.pone.0195392
10.1128/CMR.00061-05
10.1086/591504
10.1128/mBio.00250-13
10.1016/j.tube.2011.07.005
10.1128/JCM.00540-08
10.1093/infdis/jit443
10.1371/journal.ppat.1005809
10.1038/s41588-018-0117-9
10.1016/S1473-3099(17)30703-X
10.1371/journal.pone.0144137
10.1186/1472-698X-10-29
10.1164/rccm.201605-1042OC
10.1038/ng.2744
10.1016/j.meegid.2012.02.004
10.1016/j.tube.2008.09.003
10.1016/S1473-3099(17)30623-0
10.1128/JCM.41.12.5640-5644.2003
10.1093/nar/gkq351
10.1016/j.ijmyco.2014.01.001
10.1186/1471-2105-11-S3-S4
10.3201/eid0805.020002
10.1056/NEJMoa1003176
10.1016/j.meegid.2013.02.015
10.1371/journal.pone.0025075
10.1371/journal.pntd.0000744
10.1089/jir.2005.25.694
10.1128/JCM.01414-15
10.1128/JCM.03566-14
10.23943/princeton/9780691154626.001.0001
10.1016/j.mib.2017.11.021
10.18637/jss.v036.i03
10.1056/NEJM199406163302402
10.1038/ng.3195
10.1016/j.tube.2015.11.007
10.1136/bmj.331.7526.1157
10.1016/j.tube.2010.08.004
10.5588/ijtld.12.0732
10.1056/NEJMra1405427 10.1056/NEJMra1405427
10.1371/journal.ppat.1002824
10.1093/aje/155.6.565
10.1371/journal.ppat.1001307
10.1016/j.tim.2011.07.002
10.1016/S1473-3099(18)30073-2
10.1371/journal.pgen.1003318
10.1016/S2213-2600(17)30079-6
10.1016/j.meegid.2012.02.010
10.1038/ng.3704
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Issue 1
Keywords Molecular epidemiology
Genotype
Tuberculosis
Mycobacterium tuberculosis
Genetic variation
Epidemiology
Language English
License Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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PublicationCentury 2000
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References T Weniger (1180_CR37) 2010; 38
A Sengupta (1180_CR58) 2005; 331
M Kato-Maeda (1180_CR61) 2010; 14
Kirsten E. Wiens (1180_CR17) 2016; 12
L DA (1180_CR62) 2010; 90
R Hershberg (1180_CR48) 2008; 6
M Salie (1180_CR11) 2014; 209
H Chae (1180_CR13) 2018; 56
J Konde-Lule (1180_CR59) 2010; 10
Y Hu (1180_CR52) 2016; 97
Institute for Health Metrics and Evaluation (IHME) (1180_CR40) 2016
M Hanekom (1180_CR12) 2011; 91
A Liberati (1180_CR24) 2009; 6
HH Kyu (1180_CR1) 2018; 18
C Demay (1180_CR35) 2012; 12
C Manca (1180_CR19) 2005; 25
I Comas (1180_CR4) 2011; 19
1180_CR41
L Toyo-oka (1180_CR10) 2017; 90
1180_CR42
BC de Jong (1180_CR54) 2008; 198
JR Glynn (1180_CR22) 2002; 8
I Comas (1180_CR60) 2009; 4
R Ramazanzadeh (1180_CR23) 2014; 3
M Aminian (1180_CR34) 2010; 11
C Allix-Béguec (1180_CR36) 2008; 46
H Nebenzahl-Guimaraes (1180_CR7) 2016; 195
AS Albanna (1180_CR51) 2011; 6
I Parwati (1180_CR43) 2010; 201
MK Lalor (1180_CR55) 2017; 15
D Portevin (1180_CR16) 2011; 7
SGD van der (1180_CR30) 2003; 41
JL Gardy (1180_CR14) 2011; 364
TN Buu (1180_CR45) 2010; 51
P Nahid (1180_CR21) 2018; 13
B Mathema (1180_CR47) 2006; 19
EM Streicher (1180_CR31) 2015; 53
K Dheda (1180_CR26) 2017; 5
I Comas (1180_CR32) 2013; 45
M Merker (1180_CR56) 2015; 47
M Zignol (1180_CR63) 2018; 18
ES Click (1180_CR57) 2013; 17
S Shang (1180_CR18) 2011; 91
B Tessema (1180_CR39) 2013; 13
KE Holt (1180_CR53) 2018; 50
L Fenner (1180_CR8) 2013; 9
BC de Jong (1180_CR50) 2010; 4
PM Small (1180_CR29) 1994; 330
JG Pasipanodya (1180_CR9) 2013; 16
GD van der Spuy (1180_CR46) 2009; 89
Christopher Dye (1180_CR3) 2017
1180_CR20
D Stucki (1180_CR49) 2016; 48
A Shabbeer (1180_CR33) 2012; 12
Laurent Abel (1180_CR5) 2018; 18
1180_CR25
M Orgeur (1180_CR6) 2018; 41
P Kasaie (1180_CR28) 2015; 10
1180_CR2
M Murray (1180_CR27) 2002; 155
SA Yimer (1180_CR38) 2015; 53
CU Köser (1180_CR15) 2012; 8
A Chatterjee (1180_CR44) 2010; 48
References_xml – volume-title: GBD compare data visualization
  year: 2016
  ident: 1180_CR40
  contributor:
    fullname: Institute for Health Metrics and Evaluation (IHME)
– volume: 48
  start-page: 3593
  year: 2010
  ident: 1180_CR44
  publication-title: J Clin Microbiol
  doi: 10.1128/JCM.00430-10
  contributor:
    fullname: A Chatterjee
– volume: 51
  start-page: 879
  year: 2010
  ident: 1180_CR45
  publication-title: Clin Infect Dis Off Publ Infect Dis Soc Am
  doi: 10.1086/656410
  contributor:
    fullname: TN Buu
– volume: 90
  start-page: 149
  year: 2017
  ident: 1180_CR10
  publication-title: HLA
  doi: 10.1111/tan.13070
  contributor:
    fullname: L Toyo-oka
– volume: 91
  start-page: 378
  year: 2011
  ident: 1180_CR18
  publication-title: Tuberc Edinb Scotl
  doi: 10.1016/j.tube.2011.06.001
  contributor:
    fullname: S Shang
– volume: 6
  start-page: e311
  year: 2008
  ident: 1180_CR48
  publication-title: PLoS Biol
  doi: 10.1371/journal.pbio.0060311
  contributor:
    fullname: R Hershberg
– volume: 4
  start-page: e7815
  year: 2009
  ident: 1180_CR60
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0007815
  contributor:
    fullname: I Comas
– volume: 15
  start-page: 105
  year: 2017
  ident: 1180_CR55
  publication-title: BMC Med
  doi: 10.1186/s12916-017-0864-y
  contributor:
    fullname: MK Lalor
– volume: 6
  start-page: e1000100
  year: 2009
  ident: 1180_CR24
  publication-title: PLoS Med
  doi: 10.1371/journal.pmed.1000100
  contributor:
    fullname: A Liberati
– volume: 13
  start-page: 131
  year: 2013
  ident: 1180_CR39
  publication-title: BMC Infect Dis
  doi: 10.1186/1471-2334-13-131
  contributor:
    fullname: B Tessema
– volume: 201
  start-page: 553
  year: 2010
  ident: 1180_CR43
  publication-title: J Infect Dis
  doi: 10.1086/650311
  contributor:
    fullname: I Parwati
– volume: 13
  start-page: e0195392
  year: 2018
  ident: 1180_CR21
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0195392
  contributor:
    fullname: P Nahid
– volume: 19
  start-page: 658
  year: 2006
  ident: 1180_CR47
  publication-title: Clin Microbiol Rev
  doi: 10.1128/CMR.00061-05
  contributor:
    fullname: B Mathema
– volume: 198
  start-page: 1037
  year: 2008
  ident: 1180_CR54
  publication-title: J Infect Dis
  doi: 10.1086/591504
  contributor:
    fullname: BC de Jong
– ident: 1180_CR20
  doi: 10.1128/mBio.00250-13
– volume: 91
  start-page: 510
  year: 2011
  ident: 1180_CR12
  publication-title: Tuberculosis
  doi: 10.1016/j.tube.2011.07.005
  contributor:
    fullname: M Hanekom
– volume: 46
  start-page: 2692
  year: 2008
  ident: 1180_CR36
  publication-title: J Clin Microbiol
  doi: 10.1128/JCM.00540-08
  contributor:
    fullname: C Allix-Béguec
– volume: 209
  start-page: 216
  year: 2014
  ident: 1180_CR11
  publication-title: J Infect Dis
  doi: 10.1093/infdis/jit443
  contributor:
    fullname: M Salie
– volume: 12
  start-page: e1005809
  issue: 8
  year: 2016
  ident: 1180_CR17
  publication-title: PLOS Pathogens
  doi: 10.1371/journal.ppat.1005809
  contributor:
    fullname: Kirsten E. Wiens
– volume: 50
  start-page: 849
  year: 2018
  ident: 1180_CR53
  publication-title: Nat Genet
  doi: 10.1038/s41588-018-0117-9
  contributor:
    fullname: KE Holt
– volume: 18
  start-page: 261
  year: 2018
  ident: 1180_CR1
  publication-title: Lancet Infect Dis
  doi: 10.1016/S1473-3099(17)30703-X
  contributor:
    fullname: HH Kyu
– volume: 10
  start-page: e0144137
  year: 2015
  ident: 1180_CR28
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0144137
  contributor:
    fullname: P Kasaie
– volume: 10
  start-page: 29
  year: 2010
  ident: 1180_CR59
  publication-title: BMC Int Health Hum Rights
  doi: 10.1186/1472-698X-10-29
  contributor:
    fullname: J Konde-Lule
– volume: 195
  start-page: 1519
  year: 2016
  ident: 1180_CR7
  publication-title: Am J Respir Crit Care Med
  doi: 10.1164/rccm.201605-1042OC
  contributor:
    fullname: H Nebenzahl-Guimaraes
– volume: 56
  start-page: 300
  year: 2018
  ident: 1180_CR13
  publication-title: J Microbiol Seoul Korea
  contributor:
    fullname: H Chae
– volume: 45
  start-page: 1176
  year: 2013
  ident: 1180_CR32
  publication-title: Nat Genet
  doi: 10.1038/ng.2744
  contributor:
    fullname: I Comas
– volume: 12
  start-page: 755
  year: 2012
  ident: 1180_CR35
  publication-title: Infect Genet Evol
  doi: 10.1016/j.meegid.2012.02.004
  contributor:
    fullname: C Demay
– volume: 89
  start-page: 120
  year: 2009
  ident: 1180_CR46
  publication-title: Tuberc Edinb Scotl
  doi: 10.1016/j.tube.2008.09.003
  contributor:
    fullname: GD van der Spuy
– volume: 18
  start-page: e64
  issue: 3
  year: 2018
  ident: 1180_CR5
  publication-title: The Lancet Infectious Diseases
  doi: 10.1016/S1473-3099(17)30623-0
  contributor:
    fullname: Laurent Abel
– volume: 14
  start-page: 538
  year: 2010
  ident: 1180_CR61
  publication-title: Int J Tuberc Lung Dis Off J Int Union Tuberc Lung Dis
  contributor:
    fullname: M Kato-Maeda
– volume: 41
  start-page: 5640
  year: 2003
  ident: 1180_CR30
  publication-title: J Clin Microbiol
  doi: 10.1128/JCM.41.12.5640-5644.2003
  contributor:
    fullname: SGD van der
– volume: 38
  start-page: W326
  issue: suppl_2
  year: 2010
  ident: 1180_CR37
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkq351
  contributor:
    fullname: T Weniger
– volume: 3
  start-page: 41
  year: 2014
  ident: 1180_CR23
  publication-title: Int J Mycobacteriology
  doi: 10.1016/j.ijmyco.2014.01.001
  contributor:
    fullname: R Ramazanzadeh
– volume: 11
  start-page: S4
  year: 2010
  ident: 1180_CR34
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-11-S3-S4
  contributor:
    fullname: M Aminian
– volume: 8
  start-page: 843
  year: 2002
  ident: 1180_CR22
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid0805.020002
  contributor:
    fullname: JR Glynn
– volume: 364
  start-page: 730
  year: 2011
  ident: 1180_CR14
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa1003176
  contributor:
    fullname: JL Gardy
– volume: 16
  start-page: 433
  year: 2013
  ident: 1180_CR9
  publication-title: Infect Genet Evol
  doi: 10.1016/j.meegid.2013.02.015
  contributor:
    fullname: JG Pasipanodya
– volume: 6
  start-page: e25075
  year: 2011
  ident: 1180_CR51
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0025075
  contributor:
    fullname: AS Albanna
– volume: 4
  start-page: e744
  year: 2010
  ident: 1180_CR50
  publication-title: PLoS Negl Trop Dis
  doi: 10.1371/journal.pntd.0000744
  contributor:
    fullname: BC de Jong
– volume: 25
  start-page: 694
  year: 2005
  ident: 1180_CR19
  publication-title: J Interf Cytokine Res
  doi: 10.1089/jir.2005.25.694
  contributor:
    fullname: C Manca
– volume: 53
  start-page: 3650
  year: 2015
  ident: 1180_CR31
  publication-title: J Clin Microbiol
  doi: 10.1128/JCM.01414-15
  contributor:
    fullname: EM Streicher
– volume: 53
  start-page: 1301
  year: 2015
  ident: 1180_CR38
  publication-title: J Clin Microbiol
  doi: 10.1128/JCM.03566-14
  contributor:
    fullname: SA Yimer
– volume-title: The Population Biology of Tuberculosis
  year: 2017
  ident: 1180_CR3
  doi: 10.23943/princeton/9780691154626.001.0001
  contributor:
    fullname: Christopher Dye
– volume: 41
  start-page: 68
  year: 2018
  ident: 1180_CR6
  publication-title: Curr Opin Microbiol
  doi: 10.1016/j.mib.2017.11.021
  contributor:
    fullname: M Orgeur
– ident: 1180_CR25
– ident: 1180_CR41
  doi: 10.18637/jss.v036.i03
– volume: 330
  start-page: 1703
  year: 1994
  ident: 1180_CR29
  publication-title: N Engl J Med
  doi: 10.1056/NEJM199406163302402
  contributor:
    fullname: PM Small
– volume: 47
  start-page: 242
  year: 2015
  ident: 1180_CR56
  publication-title: Nat Genet
  doi: 10.1038/ng.3195
  contributor:
    fullname: M Merker
– volume: 97
  start-page: 18
  issue: Supplement C
  year: 2016
  ident: 1180_CR52
  publication-title: Tuberculosis
  doi: 10.1016/j.tube.2015.11.007
  contributor:
    fullname: Y Hu
– volume: 331
  start-page: 1157
  year: 2005
  ident: 1180_CR58
  publication-title: BMJ
  doi: 10.1136/bmj.331.7526.1157
  contributor:
    fullname: A Sengupta
– volume: 90
  start-page: 319
  year: 2010
  ident: 1180_CR62
  publication-title: Tuberculosis
  doi: 10.1016/j.tube.2010.08.004
  contributor:
    fullname: L DA
– volume: 17
  start-page: 878
  year: 2013
  ident: 1180_CR57
  publication-title: Int J Tuberc Lung Dis
  doi: 10.5588/ijtld.12.0732
  contributor:
    fullname: ES Click
– ident: 1180_CR2
  doi: 10.1056/NEJMra1405427 10.1056/NEJMra1405427
– ident: 1180_CR42
– volume: 8
  start-page: e1002824
  year: 2012
  ident: 1180_CR15
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1002824
  contributor:
    fullname: CU Köser
– volume: 155
  start-page: 565
  year: 2002
  ident: 1180_CR27
  publication-title: Am J Epidemiol
  doi: 10.1093/aje/155.6.565
  contributor:
    fullname: M Murray
– volume: 7
  start-page: e1001307
  year: 2011
  ident: 1180_CR16
  publication-title: PLoS Pathog
  doi: 10.1371/journal.ppat.1001307
  contributor:
    fullname: D Portevin
– volume: 19
  start-page: 492
  year: 2011
  ident: 1180_CR4
  publication-title: Trends Microbiol
  doi: 10.1016/j.tim.2011.07.002
  contributor:
    fullname: I Comas
– volume: 18
  start-page: 675
  year: 2018
  ident: 1180_CR63
  publication-title: Lancet Infect Dis
  doi: 10.1016/S1473-3099(18)30073-2
  contributor:
    fullname: M Zignol
– volume: 9
  start-page: e1003318
  year: 2013
  ident: 1180_CR8
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1003318
  contributor:
    fullname: L Fenner
– volume: 5
  start-page: 291
  year: 2017
  ident: 1180_CR26
  publication-title: Lancet Respir Med
  doi: 10.1016/S2213-2600(17)30079-6
  contributor:
    fullname: K Dheda
– volume: 12
  start-page: 789
  year: 2012
  ident: 1180_CR33
  publication-title: Infect Genet Evol
  doi: 10.1016/j.meegid.2012.02.010
  contributor:
    fullname: A Shabbeer
– volume: 48
  start-page: 1535
  year: 2016
  ident: 1180_CR49
  publication-title: Nat Genet
  doi: 10.1038/ng.3704
  contributor:
    fullname: D Stucki
SSID ssj0025774
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Snippet The host, microbial, and environmental factors that contribute to variation in tuberculosis (TB) disease are incompletely understood. Accumulating evidence...
Background The host, microbial, and environmental factors that contribute to variation in tuberculosis (TB) disease are incompletely understood. Accumulating...
Abstract Background The host, microbial, and environmental factors that contribute to variation in tuberculosis (TB) disease are incompletely understood....
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SubjectTerms Bacteria
Chains
Data collection
Disease transmission
Drug resistance
Environmental factors
Epidemiology
Evidence-based medicine
Failure analysis
Genetic variation
Genotype
Genotypes
Health services
Heterogeneity
Literature reviews
Meta-analysis
Microorganisms
Molecular epidemiology
Mycobacterium tuberculosis
Reviews
Risk management
Sampling methods
Strains (organisms)
Systematic review
Tuberculosis
Variation
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Title Global variation in bacterial strains that cause tuberculosis disease: a systematic review and meta-analysis
URI https://www.ncbi.nlm.nih.gov/pubmed/30373589
https://www.proquest.com/docview/2135100655
https://pubmed.ncbi.nlm.nih.gov/PMC6206891
https://doaj.org/article/a956ef597a694eee8ea83fbee6daff7d
Volume 16
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