Switch in KRAS mutational status during an unusual course of disease in a patient with advanced pancreatic adenocarcinoma: implications for translational research

• Published in: BMC cancer Vol. 17; no. 1; pp. 374 - 5
• Main Authors: Baechmann, Sibylle, Ormanns, Steffen, Haas, Michael, Kruger, Stephan, Remold, Anna, Modest, Dominik Paul, Kirchner, Thomas, Jung, Andreas, Werner, Jens, Heinemann, Volker, Boeck, Stefan
• Format: Journal Article
• Language: English
• Published: England BioMed Central 26.05.2017; BMC
• Subjects: Adenocarcinoma; Aged; Biomarkers; Biopsy; Cancer therapies; Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - pathology; Carcinoma, Pancreatic Ductal - therapy; Case Report; Chemoradiotherapy; Chemoradiotherapy - methods; Chemotherapy; Clinical trials; Colorectal cancer; Deoxycytidine - analogs & derivatives; Deoxycytidine - therapeutic use; Disease; Disease control; Epidermal growth factor; Epidermal growth factor receptors; Evolution & development; Female; Fluorouracil - therapeutic use; Gemcitabine; Genes; Humans; K-Ras protein; Kinases; KRAS mutation; Lymph; Lymph nodes; Lymphatic system; Medical prognosis; Metastasis; Mutation; Neoplasm Recurrence, Local - genetics; Neoplasm Recurrence, Local - pathology; Neoplasm Recurrence, Local - therapy; Oncology; Oral cavity; Paclitaxel; Pancreas; Pancreas transplantation; Pancreatic cancer; Pancreatic ductal adenocarcinoma (PDAC); Pancreatic Neoplasms; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - therapy; Pancreaticoduodenectomy; Patients; Point mutation; Proto-Oncogene Proteins p21(ras) - genetics; Survival; Translation; Translational Research, Biomedical; Tumor heterogeneity; Tumors; Tumor heterogeneity; KRAS mutation; Pancreatic ductal adenocarcinoma (PDAC)

Despite the introduction of novel effective treatment regimens like gemcitabine plus nab-paclitaxel and FOLFIRINOX, pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive epithelial tumors. Among the genetic alterations frequently found in PDAC, mutations in the KRAS gene might p...