Contrasting Effects of Natural Selection on Human and Chimpanzee CC Chemokine Receptor 5

• Published in: American journal of human genetics Vol. 76; no. 2; pp. 291 - 301
• Main Authors: Wooding, Stephen, Stone, Anne C., Dunn, Diane M., Mummidi, Srinivas, Jorde, Lynn B., Weiss, Robert K., Ahuja, Sunil, Bamshad, Michael J.
• Format: Journal Article
• Language: English
• Published: Chicago, IL Elsevier Inc 01.02.2005; University of Chicago Press; Cell Press; American Society of Human Genetics
• Subjects: Acquired Immunodeficiency Syndrome - genetics; Acquired Immunodeficiency Syndrome - transmission; Animals; Biological and medical sciences; Deoxyribonucleic acid; Disease Progression; Disease transmission; DNA; General aspects. Genetic counseling; Genetic Variation; HIV; HIV-1 - pathogenicity; Human Genome Project; Human immunodeficiency virus; Human immunodeficiency virus 1; Humans; Immunity, Innate; Leukocytes; Medical genetics; Medical sciences; Monkeys & apes; Pan troglodytes; Pan troglodytes - genetics; Receptors, CCR5 - genetics; Selection, Genetic; Sequence Analysis, DNA; Simian Acquired Immunodeficiency Syndrome - genetics; Simian Acquired Immunodeficiency Syndrome - transmission; Simian immunodeficiency virus; Simian Immunodeficiency Virus - pathogenicity; Human; Genetics; CC chemokine receptor; Natural selection

Human immunodeficiency virus type 1 (HIV-1) evolved via cross-species transmission of simian immunodeficiency virus (SIVcpz) from chimpanzees ( Pan troglodytes). Chimpanzees, like humans, are susceptible to infection by HIV-1. However, unlike humans, infected chimpanzees seldom develop immunodeficie...