POTENTIAL TOXICITY OF NONREGULATED ASBESTIFORM MINERALS: BALANGEROITE FROM THE WESTERN ALPS. PART 2: OXIDANT ACTIVITY OF THE FIBERS

• Published in: Journal of Toxicology and Environmental Health, Part A Vol. 68; no. 1; pp. 21 - 39
• Main Authors: Turci, Francesco, Tomatis, Maura, Gazzano, Elena, Riganti, Chiara, Martra, Gianmario, Bosia, Amalia, Ghigo, Dario, Fubini, Bice
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Group 08.01.2005
• Subjects: Adsorption; Asbestos, Crocidolite - toxicity; Asbestos, Serpentine - toxicity; Calorimetry; Chelating Agents - chemistry; Chelating Agents - pharmacology; Electron Spin Resonance Spectroscopy; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Free Radicals - chemistry; Humans; Hydrogen Peroxide - chemistry; Indicators and Reagents; Iron - metabolism; Lipid Peroxidation - drug effects; Malondialdehyde - metabolism; Mineral Fibers - toxicity; Nitric Oxide - biosynthesis; Nitric Oxide - chemistry; Nitric Oxide Synthase - metabolism; Oxidants - toxicity; Oxidative Stress - drug effects; Spectroscopy, Fourier Transform Infrared; Thiobarbituric Acid Reactive Substances - metabolism; Italy, Alps Mts

The asbestiform mineral balangeroite [(Mg,Fe 2+ ,Fe 3+ ,Mn 2+ ) 42 Si 16 O 54 (OH) 36 ], whose toxic potential is unknown, is associated with chrysotile asbestos in the western Alps (Balangero mine, Piedmont, Italy). In order to examine whether such fibers may contribute to the oxidative damage prod...