Influence of the genetic polymorphism in the 5′-noncoding region of the CYP1A2 gene on CYP1A2 phenotype and urinary mutagenicity in smokers

• Published in: Mutation research Vol. 587; no. 1; pp. 59 - 66
• Main Authors: Pavanello, Sofia, Pulliero, Alessandra, Lupi, Silvia, Gregorio, Pasquale, Clonfero, Erminio
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 10.11.2005; Elsevier
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Caffeine test; CYP1A2 genotype; CYP1A2 phenotype; Cytochrome P-450 CYP1A2 - genetics; Cytochrome P-450 CYP1A2 - metabolism; Female; Fundamental and applied biological sciences. Psychology; Genetics of eukaryotes. Biological and molecular evolution; Genotype; Humans; Individual susceptibility; Male; Medical sciences; Middle Aged; Phenotype; Polymorphism, Genetic; Promoter Regions, Genetic; Salmonella typhimurium; Smoking - adverse effects; Smoking - genetics; Tobacco smoke exposure; Tobacco smoke-induced CYP1A2 activity; Tobacco, tobacco smoking; Toxicology; Urinary mutagenicity; Tobacco smoke exposure; 1U; CYP1A2 phenotype; Urinary mutagenicity; 1X; CMR; Caffeine test; 17U; Individual susceptibility; AAs; AFMU; NA; CYP1A2; SNPs; PAHs; CYP1A2 genotype; HAs; Tobacco smoke-induced CYP1A2 activity; Urine; Tobacco smoke; CNS stimulant; Psychotropic; Toxicity; Tobacco smoking; Exploration; Respiratory analeptic; Urinary mutagenicity: Individual susceptibility; Toxicology; CYPIA2 genotype; Genetics; Caffeine
• ISSN: 1383-5718; 0027-5107; 1879-3592
• DOI: 10.1016/j.mrgentox.2005.08.008

The functional significance of genetic polymorphisms on tobacco smoke-induced CYP1A2 activity was examined. The influence of three polymorphisms of the cytochrome P450 1A2 gene ( CYP1A2) (− 3860 G → A (allele *1C), − 2467 T → delT (allele *1D), − 163 C → A (allele *1F)), located in the 5′-noncoding...