NCAM1/FGF module serves as a putative pleuropulmonary blastoma therapeutic target

• Published in: Oncogenesis (New York, NY) Vol. 8; no. 9; pp. 48 - 12
• Main Authors: Shukrun, Rachel, Golan, Hana, Caspi, Revital, Pode-Shakked, Naomi, Pleniceanu, Oren, Vax, Einav, Bar-Lev, Dekel D, Pri-Chen, Sara, Jacob-Hirsch, Jasmine, Schiby, Ginette, Harari-Steinberg, Orit, Mark-Danieli, Michal, Dekel, Benjamin, Toren, Amos
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 02.09.2019; Nature Publishing Group UK
• Subjects: Cell adhesion & migration; Cell adhesion molecules; Cell culture; Embryogenesis; Fibroblast growth factor receptors; Lungs; Mesenchyme; Neoplasia; Neural cell adhesion molecule; Stroma; Therapeutic applications; Tumors; Xenografts

Pleuropulmonary blastoma (PPB) is a rare pediatric lung neoplasm that recapitulates developmental pathways of early embryonic lungs. As lung development proceeds with highly regulated mesenchymal-epithelial interactions, a DICER1 mutation in PPB generates a faulty lung differentiation program with r...