Synthesis and Antifungal Potential of Some Novel Benzimidazole-1,3,4-Oxadiazole Compounds

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 1; p. 191
• Main Authors: Karaburun, Ahmet Çağrı, Kaya Çavuşoğlu, Betül, Acar Çevik, Ulviye, Osmaniye, Derya, Sağlık, Begüm Nurpelin, Levent, Serkan, Özkay, Yusuf, Atlı, Özlem, Koparal, Ali Savaş, Kaplancıklı, Zafer Asım
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.01.2019; MDPI
• Subjects: 1,3,4-oxadiazole; Amphotericin B; Antifungal activity; Antifungal agents; benzimidazole; Benzimidazoles; Biosynthesis; Carbon; cytotoxicity; Drug resistance; Drugs; Enzymes; Ergosterol; ergosterol biosynthesis; Evaluation; Fungal infections; Fungi; Fungicides; Ketoconazole; Lanosterol; molecular docking; Oxadiazoles; benzimidazole; molecular docking; antifungal activity; 1,3,4-oxadiazole; cytotoxicity; ergosterol biosynthesis

Discovery of novel anticandidal agents with clarified mechanisms of action, could be a rationalist approach against diverse pathogenic fungal strains due to the rise of resistance to existing drugs. In support to this hypothesis, in this paper, a series of benzimidazole-oxadiazole compounds were syn...