Ontogeny of Stromal Organizer Cells during Lymph Node Development

• Published in: The Journal of immunology (1950) Vol. 184; no. 8; pp. 4521 - 4530
• Main Authors: Benezech, Cecile, White, Andrea, Mader, Emma, Serre, Karine, Parnell, Sonia, Pfeffer, Klaus, Ware, Carl F, Anderson, Graham, Caamano, Jorge H
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.04.2010
• Subjects: Animals; B-Lymphocyte Subsets - cytology; B-Lymphocyte Subsets - immunology; B-Lymphocyte Subsets - metabolism; Cell Differentiation - genetics; Cell Differentiation - immunology; Endothelium, Lymphatic - cytology; Endothelium, Lymphatic - embryology; Endothelium, Lymphatic - metabolism; Immunophenotyping; Lymph Nodes - cytology; Lymph Nodes - embryology; Lymph Nodes - immunology; Lymph Nodes - metabolism; Mesenchymal Stem Cells - cytology; Mesenchymal Stem Cells - immunology; Mesenchymal Stem Cells - metabolism; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Organ Culture Techniques; Stromal Cells - cytology; Stromal Cells - immunology; Stromal Cells - metabolism; T-Lymphocyte Subsets - cytology; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism

The development of secondary lymphoid organs, such as lymph nodes (LNs), in the embryo results from the reciprocal action between lymphoid tissue inducer (LTi) cells and stromal cells. However, the initial events inducing LN anlagen formation before the LTi stromal cells cross-talk interactions take...