Dual-Responsive Alginate Hydrogel Constructed by Sulfhdryl Dendrimer as an Intelligent System for Drug Delivery
Intelligent stimulus-triggered release and high drug-loading capacity are crucial requirements for drug delivery systems in cancer treatment. Based on the excessive intracellular GSH expression and pH conditions in tumor cells, a novel glutathione (GSH) and pH dual-responsive hydrogel was designed a...
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| Published in | Molecules (Basel, Switzerland) Vol. 27; no. 1; p. 281 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
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03.01.2022
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| Abstract | Intelligent stimulus-triggered release and high drug-loading capacity are crucial requirements for drug delivery systems in cancer treatment. Based on the excessive intracellular GSH expression and pH conditions in tumor cells, a novel glutathione (GSH) and pH dual-responsive hydrogel was designed and synthesized by conjugates of glutamic acid-cysteine dendrimer with alginate (
) through click reaction, and then cross-linked with polyethylene glycol (PEG) through hydrogen bonds to form a 3D-net structure. The hydrogel, self-assembled by the inner disulfide bonds of the dendrimer, is designed to respond to the GSH heterogeneity in tumors, with a remarkably high drug loading capacity. The Dox-loaded
hydrogel showed controlled drug release behavior, significantly with a release rate of over 76% in response to GSH. The cytotoxicity investigation indicated that the prepared DOX-loaded hydrogel exhibited comparable anti-tumor activity against HepG-2 cells with positive control. These biocompatible hydrogels are expected to be well-designed GSH and pH dual-sensitive conjugates or polymers for efficient anticancer drug delivery. |
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| AbstractList | Intelligent stimulus-triggered release and high drug-loading capacity are crucial requirements for drug delivery systems in cancer treatment. Based on the excessive intracellular GSH expression and pH conditions in tumor cells, a novel glutathione (GSH) and pH dual-responsive hydrogel was designed and synthesized by conjugates of glutamic acid-cysteine dendrimer with alginate (
) through click reaction, and then cross-linked with polyethylene glycol (PEG) through hydrogen bonds to form a 3D-net structure. The hydrogel, self-assembled by the inner disulfide bonds of the dendrimer, is designed to respond to the GSH heterogeneity in tumors, with a remarkably high drug loading capacity. The Dox-loaded
hydrogel showed controlled drug release behavior, significantly with a release rate of over 76% in response to GSH. The cytotoxicity investigation indicated that the prepared DOX-loaded hydrogel exhibited comparable anti-tumor activity against HepG-2 cells with positive control. These biocompatible hydrogels are expected to be well-designed GSH and pH dual-sensitive conjugates or polymers for efficient anticancer drug delivery. Intelligent stimulus-triggered release and high drug-loading capacity are crucial requirements for drug delivery systems in cancer treatment. Based on the excessive intracellular GSH expression and pH conditions in tumor cells, a novel glutathione (GSH) and pH dual-responsive hydrogel was designed and synthesized by conjugates of glutamic acid-cysteine dendrimer with alginate (Glu-Cys-SA) through click reaction, and then cross-linked with polyethylene glycol (PEG) through hydrogen bonds to form a 3D-net structure. The hydrogel, self-assembled by the inner disulfide bonds of the dendrimer, is designed to respond to the GSH heterogeneity in tumors, with a remarkably high drug loading capacity. The Dox-loaded Glu-Cys-SA hydrogel showed controlled drug release behavior, significantly with a release rate of over 76% in response to GSH. The cytotoxicity investigation indicated that the prepared DOX-loaded hydrogel exhibited comparable anti-tumor activity against HepG-2 cells with positive control. These biocompatible hydrogels are expected to be well-designed GSH and pH dual-sensitive conjugates or polymers for efficient anticancer drug delivery. Intelligent stimulus-triggered release and high drug-loading capacity are crucial requirements for drug delivery systems in cancer treatment. Based on the excessive intracellular GSH expression and pH conditions in tumor cells, a novel glutathione (GSH) and pH dual-responsive hydrogel was designed and synthesized by conjugates of glutamic acid-cysteine dendrimer with alginate ( Glu-Cys-SA ) through click reaction, and then cross-linked with polyethylene glycol (PEG) through hydrogen bonds to form a 3D-net structure. The hydrogel, self-assembled by the inner disulfide bonds of the dendrimer, is designed to respond to the GSH heterogeneity in tumors, with a remarkably high drug loading capacity. The Dox-loaded Glu-Cys-SA hydrogel showed controlled drug release behavior, significantly with a release rate of over 76% in response to GSH. The cytotoxicity investigation indicated that the prepared DOX-loaded hydrogel exhibited comparable anti-tumor activity against HepG-2 cells with positive control. These biocompatible hydrogels are expected to be well-designed GSH and pH dual-sensitive conjugates or polymers for efficient anticancer drug delivery. |
| Author | Lei, Dongyu Li, Jiashan Jin, Lu Pan, Le Li, Li Xu, Lu Zhang, Jiaojiao |
| AuthorAffiliation | 2 The Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Jiangnan University, Wuxi 214122, China 1 Chemical Engineering College, Xinjiang Agricultural University, Urumqi 830052, China; lizixi19950707@163.com (L.L.); koh9391421@163.com (J.Z.); lur281644038@163.com (L.X.); lijiashan3333@163.com (J.L.) 3 Department of Physiology, Preclinical School, Xinjiang Medical University, Urumqi 830011, China; leidongyu0109@163.com |
| AuthorAffiliation_xml | – name: 3 Department of Physiology, Preclinical School, Xinjiang Medical University, Urumqi 830011, China; leidongyu0109@163.com – name: 1 Chemical Engineering College, Xinjiang Agricultural University, Urumqi 830052, China; lizixi19950707@163.com (L.L.); koh9391421@163.com (J.Z.); lur281644038@163.com (L.X.); lijiashan3333@163.com (J.L.) – name: 2 The Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Jiangnan University, Wuxi 214122, China |
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| Copyright | 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2022 by the authors. 2022 |
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| SubjectTerms | Acids Alginates Alginates - chemistry Alginates - pharmacokinetics Alginates - pharmacology Alginic acid Animals anti-tumor activity Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacokinetics Antineoplastic Agents - pharmacology Biocompatibility Biopolymers Chemical bonds Chromatography Conjugates Cytotoxicity Delayed-Action Preparations - chemistry Delayed-Action Preparations - pharmacokinetics Delayed-Action Preparations - pharmacology dendrimer modified hydrogel Dendrimers - chemistry Dendrimers - pharmacokinetics Dendrimers - pharmacology Design Disulfide bonds Doxycycline - chemistry Doxycycline - pharmacokinetics Doxycycline - pharmacology Drug delivery Drug delivery systems Glutamic acid GSH- and pH-responsive Hep G2 Cells Heterogeneity Humans Hydrogels Hydrogels - chemical synthesis Hydrogels - chemistry Hydrogels - pharmacokinetics Hydrogels - pharmacology Hydrogen bonding Hydrogen bonds Investigations Mice Morphology Neoplasms - drug therapy Neoplasms - metabolism Polyethylene glycol Polymers Self-assembly Sodium Tumor cells Tumors |
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| Title | Dual-Responsive Alginate Hydrogel Constructed by Sulfhdryl Dendrimer as an Intelligent System for Drug Delivery |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/35011513 https://www.proquest.com/docview/2618242025 https://search.proquest.com/docview/2618908672 https://pubmed.ncbi.nlm.nih.gov/PMC8746751 https://doaj.org/article/32adb5138a5e483bb5c2a2118e90b0e5 |
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