Chronic exposure to heavy metals and risk of oral cancer in Taiwanese males
The incidence of oral cancer has increased rapidly over the past 20 years in Taiwan. Cigarette smoking and betel quid chewing are considered as the most important risk factors. However, we found that Changhua, a county in Taiwan, had the highest oral cancer incidence, but a modest prevalence of smok...
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| Published in | Oral oncology Vol. 46; no. 8; pp. 586 - 590 |
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| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
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England
Elsevier Ltd
01.08.2010
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| Abstract | The incidence of oral cancer has increased rapidly over the past 20
years in Taiwan. Cigarette smoking and betel quid chewing are considered as the most important risk factors. However, we found that Changhua, a county in Taiwan, had the highest oral cancer incidence, but a modest prevalence of smoking and betel quid chewing. Our previous study found that the incidence of oral cancer in Taiwan has a strong spatial correlation with the heavy metal concentrations in farm soils of patients’ residential areas. A high content of heavy metals in farm soil is likely the result of industrial activities. If exposure to heavy metals is a risk factor for oral cancer, we would expect to find evidence from epidemiologic trends. The age–period–cohort model was used to analyze chart records from the Taiwan Cancer Registry of 21,135 male patients diagnosed with oral cancer from 1983 to 2002. Although the incidence increased in both Changhua and Taiwan overall, Changhua had a similar incidence to that in Taiwan as a whole until 1990, when the incidence in Changhua began to speed up, leaving a marked difference with that in Taiwan. Exposure to the heavy metal pollution for a period of more than 10
years has an impact on the incidence of oral cancer. This novel factor can explain the extremely high incidence in Changhua. |
|---|---|
| AbstractList | The incidence of oral cancer has increased rapidly over the past 20years in Taiwan. Cigarette smoking and betel quid chewing are considered as the most important risk factors. However, we found that Changhua, a county in Taiwan, had the highest oral cancer incidence, but a modest prevalence of smoking and betel quid chewing. Our previous study found that the incidence of oral cancer in Taiwan has a strong spatial correlation with the heavy metal concentrations in farm soils of patients' residential areas. A high content of heavy metals in farm soil is likely the result of industrial activities. If exposure to heavy metals is a risk factor for oral cancer, we would expect to find evidence from epidemiologic trends. The age-period-cohort model was used to analyze chart records from the Taiwan Cancer Registry of 21,135 male patients diagnosed with oral cancer from 1983 to 2002. Although the incidence increased in both Changhua and Taiwan overall, Changhua had a similar incidence to that in Taiwan as a whole until 1990, when the incidence in Changhua began to speed up, leaving a marked difference with that in Taiwan. Exposure to the heavy metal pollution for a period of more than 10years has an impact on the incidence of oral cancer. This novel factor can explain the extremely high incidence in Changhua. Summary The incidence of oral cancer has increased rapidly over the past 20 years in Taiwan. Cigarette smoking and betel quid chewing are considered as the most important risk factors. However, we found that Changhua, a county in Taiwan, had the highest oral cancer incidence, but a modest prevalence of smoking and betel quid chewing. Our previous study found that the incidence of oral cancer in Taiwan has a strong spatial correlation with the heavy metal concentrations in farm soils of patients’ residential areas. A high content of heavy metals in farm soil is likely the result of industrial activities. If exposure to heavy metals is a risk factor for oral cancer, we would expect to find evidence from epidemiologic trends. The age–period–cohort model was used to analyze chart records from the Taiwan Cancer Registry of 21,135 male patients diagnosed with oral cancer from 1983 to 2002. Although the incidence increased in both Changhua and Taiwan overall, Changhua had a similar incidence to that in Taiwan as a whole until 1990, when the incidence in Changhua began to speed up, leaving a marked difference with that in Taiwan. Exposure to the heavy metal pollution for a period of more than 10 years has an impact on the incidence of oral cancer. This novel factor can explain the extremely high incidence in Changhua. The incidence of oral cancer has increased rapidly over the past 20 years in Taiwan. Cigarette smoking and betel quid chewing are considered as the most important risk factors. However, we found that Changhua, a county in Taiwan, had the highest oral cancer incidence, but a modest prevalence of smoking and betel quid chewing. Our previous study found that the incidence of oral cancer in Taiwan has a strong spatial correlation with the heavy metal concentrations in farm soils of patients’ residential areas. A high content of heavy metals in farm soil is likely the result of industrial activities. If exposure to heavy metals is a risk factor for oral cancer, we would expect to find evidence from epidemiologic trends. The age–period–cohort model was used to analyze chart records from the Taiwan Cancer Registry of 21,135 male patients diagnosed with oral cancer from 1983 to 2002. Although the incidence increased in both Changhua and Taiwan overall, Changhua had a similar incidence to that in Taiwan as a whole until 1990, when the incidence in Changhua began to speed up, leaving a marked difference with that in Taiwan. Exposure to the heavy metal pollution for a period of more than 10 years has an impact on the incidence of oral cancer. This novel factor can explain the extremely high incidence in Changhua. The incidence of oral cancer has increased rapidly over the past 20years in Taiwan. Cigarette smoking and betel quid chewing are considered as the most important risk factors. However, we found that Changhua, a county in Taiwan, had the highest oral cancer incidence, but a modest prevalence of smoking and betel quid chewing. Our previous study found that the incidence of oral cancer in Taiwan has a strong spatial correlation with the heavy metal concentrations in farm soils of patients' residential areas. A high content of heavy metals in farm soil is likely the result of industrial activities. If exposure to heavy metals is a risk factor for oral cancer, we would expect to find evidence from epidemiologic trends. The age-period-cohort model was used to analyze chart records from the Taiwan Cancer Registry of 21,135 male patients diagnosed with oral cancer from 1983 to 2002. Although the incidence increased in both Changhua and Taiwan overall, Changhua had a similar incidence to that in Taiwan as a whole until 1990, when the incidence in Changhua began to speed up, leaving a marked difference with that in Taiwan. Exposure to the heavy metal pollution for a period of more than 10years has an impact on the incidence of oral cancer. This novel factor can explain the extremely high incidence in Changhua.The incidence of oral cancer has increased rapidly over the past 20years in Taiwan. Cigarette smoking and betel quid chewing are considered as the most important risk factors. However, we found that Changhua, a county in Taiwan, had the highest oral cancer incidence, but a modest prevalence of smoking and betel quid chewing. Our previous study found that the incidence of oral cancer in Taiwan has a strong spatial correlation with the heavy metal concentrations in farm soils of patients' residential areas. A high content of heavy metals in farm soil is likely the result of industrial activities. If exposure to heavy metals is a risk factor for oral cancer, we would expect to find evidence from epidemiologic trends. The age-period-cohort model was used to analyze chart records from the Taiwan Cancer Registry of 21,135 male patients diagnosed with oral cancer from 1983 to 2002. Although the incidence increased in both Changhua and Taiwan overall, Changhua had a similar incidence to that in Taiwan as a whole until 1990, when the incidence in Changhua began to speed up, leaving a marked difference with that in Taiwan. Exposure to the heavy metal pollution for a period of more than 10years has an impact on the incidence of oral cancer. This novel factor can explain the extremely high incidence in Changhua. |
| Author | Lin, Yo-Yu Lian, Ie-Bin Su, Che-Chun Hsu, Yun-Ying Tsai, Kuo-Yang |
| Author_xml | – sequence: 1 givenname: Che-Chun surname: Su fullname: Su, Che-Chun organization: Department of Internal Medicine, Changhua Christian Hospital, 135, Nan-Hsiao Street, Changhua 500, Taiwan – sequence: 2 givenname: Kuo-Yang surname: Tsai fullname: Tsai, Kuo-Yang organization: Department of Oral and Maxillofacial Surgery, Changhua Christian Hospital, 135, Nan-Hsiao Street, Changhua 500, Taiwan – sequence: 3 givenname: Yun-Ying surname: Hsu fullname: Hsu, Yun-Ying organization: Graduate Institute of Statistics and Information Science, National Changhua University of Education, Changhua 500, Taiwan – sequence: 4 givenname: Yo-Yu surname: Lin fullname: Lin, Yo-Yu organization: Graduate Institute of Statistics and Information Science, National Changhua University of Education, Changhua 500, Taiwan – sequence: 5 givenname: Ie-Bin surname: Lian fullname: Lian, Ie-Bin email: maiblian@cc.ncue.edu.tw organization: Graduate Institute of Statistics and Information Science, National Changhua University of Education, Changhua 500, Taiwan |
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years in Taiwan. Cigarette smoking and betel quid chewing are considered as the most... Summary The incidence of oral cancer has increased rapidly over the past 20 years in Taiwan. Cigarette smoking and betel quid chewing are considered as the... The incidence of oral cancer has increased rapidly over the past 20years in Taiwan. Cigarette smoking and betel quid chewing are considered as the most... |
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| SubjectTerms | Adult Aged Age–period–cohort model Agriculture - methods Cohort Studies Heavy metal Hematology, Oncology and Palliative Medicine Humans Male Metals, Heavy - toxicity Middle Aged Mouth Neoplasms - chemically induced Mouth Neoplasms - epidemiology Oral cancer Otolaryngology Prevalence Risk Factors Soil - chemistry Soil Pollutants - toxicity Taiwan - epidemiology Young Adult |
| Title | Chronic exposure to heavy metals and risk of oral cancer in Taiwanese males |
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