CYLD suppression enhances the pro-inflammatory effects and hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes by enhancing NF-κB activation

• Published in: Arthritis research & therapy Vol. 20; no. 1; pp. 219 - 13
• Main Authors: Zhang, Le-meng, Zhou, Jing-Jing, Luo, Chun-lei
• Format: Journal Article
• Language: English
• Published: England BioMed Central 03.10.2018; BMC
• Subjects: Apoptosis; Arthritis; Cell cycle; Cell division; Cell growth; Cylindromatosis (CYLD); Cytokines; Enzymes; Fibroblast-like synoviocyte (FLS); Fibroblasts; Hyperproliferation; Inflammation; Ligands; Nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB); Pathogenesis; Pro-inflammatory cytokines; Rheumatoid arthritis; Rheumatoid arthritis (RA); Rodents; Tumor necrosis factor-TNF; Rheumatoid arthritis (RA); Pro-inflammatory cytokines; Nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB); Cylindromatosis (CYLD); Fibroblast-like synoviocyte (FLS); Hyperproliferation

Rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) actively drive joint inflammation and degradation by producing inflammatory cytokines and matrix-degrading molecules, making them key factors in the pathogenesis of RA. Cylindromatosis (CYLD) is a tumor suppressor that downregulates nuclear...