Excitation and Inhibition Imbalance in Rett Syndrome

• Published in: Frontiers in neuroscience Vol. 16; p. 825063
• Main Author: Li, Wei
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 18.02.2022; Frontiers Media S.A
• Subjects: Autism; Brain research; Convulsions & seizures; Coordination; excitation/inhibition balance; Hyperactivity; MeCP2; MeCP2 protein; Methyl-CpG binding protein; Mutation; neurodevelopmental disorder; Neurodevelopmental disorders; Neuroscience; Pathogenesis; Rett syndrome; Rodents; Seizures; synaptic transmission; MeCP2; synaptic transmission; excitation/inhibition balance; neurodevelopmental disorder; Rett syndrome

A loss of the excitation/inhibition (E/I) balance in the neural circuit has emerged as a common neuropathological feature in many neurodevelopmental disorders. Rett syndrome (RTT), a prevalent neurodevelopmental disorder that affects 1:10,000–15,000 women globally, is caused by loss-of-function muta...