Choline Chloride-Based DES as Solvents/Catalysts/Chemical Donors in Pharmaceutical Synthesis

DES are mixtures of two or more compounds, able to form liquids upon mixing, with lower freezing points when compared to the individual constituents (eutectic mixtures). This attitude is due to the specific hydrogen-bond interactions network between the components of the mixture. A notable character...

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Published inMolecules (Basel, Switzerland) Vol. 26; no. 20; p. 6286
Main Authors Amoroso, Rosa, Hollmann, Frank, Maccallini, Cristina
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 18.10.2021
MDPI
Subjects
Binding sites
Catalysis
catalyst
Catalysts
Chemistry
Chloride
Choline
Choline - chemistry
choline chloride
Dilution
Freezing
Freezing point
Hydrogen Bonding
Hydrogen bonds
Melting points
NADES
NMR
Nuclear magnetic resonance
Pharmaceutical industry
Pharmaceutical Preparations - chemistry
Pharmaceuticals
Review
Solubility
solvent
Solvents
Solvents - chemistry
Transition Temperature
Viscosity
solvent
pharmaceuticals
catalyst
choline chloride
NADES
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Abstract DES are mixtures of two or more compounds, able to form liquids upon mixing, with lower freezing points when compared to the individual constituents (eutectic mixtures). This attitude is due to the specific hydrogen-bond interactions network between the components of the mixture. A notable characteristic of DES is the possibility to develop tailor-made mixtures by changing the components ratios or a limited water dilution, for special applications, making them attractive for pharmaceutical purposes. In this review, we focused our attention on application of ChCl-based DES in the synthesis of pharmaceutical compounds. In this context, these eutectic mixtures can be used as solvents, solvents/catalysts, or as chemical donors and we explored some representative examples in recent literature of such applications.
AbstractList DES are mixtures of two or more compounds, able to form liquids upon mixing, with lower freezing points when compared to the individual constituents (eutectic mixtures). This attitude is due to the specific hydrogen-bond interactions network between the components of the mixture. A notable characteristic of DES is the possibility to develop tailor-made mixtures by changing the components ratios or a limited water dilution, for special applications, making them attractive for pharmaceutical purposes. In this review, we focused our attention on application of ChCl-based DES in the synthesis of pharmaceutical compounds. In this context, these eutectic mixtures can be used as solvents, solvents/catalysts, or as chemical donors and we explored some representative examples in recent literature of such applications.
Author Maccallini, Cristina
Hollmann, Frank
Amoroso, Rosa
AuthorAffiliation 2 Department of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, The Netherlands; f.hollmann@tudelft.nl
1 Department of Pharmacy, University of Chieti, Via dei Vestini 31, 66100 Chieti, Italy; cristina.maccallini@unich.it
AuthorAffiliation_xml – name: 1 Department of Pharmacy, University of Chieti, Via dei Vestini 31, 66100 Chieti, Italy; cristina.maccallini@unich.it
– name: 2 Department of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, The Netherlands; f.hollmann@tudelft.nl
Author_xml – sequence: 1
  givenname: Rosa
  orcidid: 0000-0002-8282-8535
  surname: Amoroso
  fullname: Amoroso, Rosa
  organization: Department of Pharmacy, University of Chieti, Via dei Vestini 31, 66100 Chieti, Italy
– sequence: 2
  givenname: Frank
  orcidid: 0000-0003-4821-756X
  surname: Hollmann
  fullname: Hollmann, Frank
  organization: Department of Biotechnology, Delft University of Technology, van der Maasweg 9, 2629 HZ Delft, The Netherlands
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  givenname: Cristina
  orcidid: 0000-0003-2957-8650
  surname: Maccallini
  fullname: Maccallini, Cristina
  organization: Department of Pharmacy, University of Chieti, Via dei Vestini 31, 66100 Chieti, Italy
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34684867$$D View this record in MEDLINE/PubMed
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2021 by the authors. 2021
Copyright_xml – notice: 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Keywords solvent
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Snippet DES are mixtures of two or more compounds, able to form liquids upon mixing, with lower freezing points when compared to the individual constituents (eutectic...
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pubmedcentral
proquest
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pubmed
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Aggregation Database
Index Database
StartPage 6286
SubjectTerms Binding sites
Catalysis
catalyst
Catalysts
Chemistry
Chloride
Choline
Choline - chemistry
choline chloride
Dilution
Freezing
Freezing point
Hydrogen Bonding
Hydrogen bonds
Melting points
NADES
NMR
Nuclear magnetic resonance
Pharmaceutical industry
Pharmaceutical Preparations - chemistry
Pharmaceuticals
Review
Solubility
solvent
Solvents
Solvents - chemistry
Transition Temperature
Viscosity
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Title Choline Chloride-Based DES as Solvents/Catalysts/Chemical Donors in Pharmaceutical Synthesis
URI https://www.ncbi.nlm.nih.gov/pubmed/34684867
https://www.proquest.com/docview/2584458380
https://search.proquest.com/docview/2584782793
https://pubmed.ncbi.nlm.nih.gov/PMC8540169
https://doaj.org/article/240ecc83e92547b6b1a7e8b6a2279cae
Volume 26
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