Synthesis, Characterisation and In Vitro Anticancer Activity of Catalytically Active Indole-Based Half-Sandwich Complexes

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 19; p. 4540
• Main Authors: Soldevila-Barreda, Joan J, Fawibe, Kehinde B, Azmanova, Maria, Rafols, Laia, Pitto-Barry, Anaïs, Eke, Uche B, Barry, Nicolas P E
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 03.10.2020; MDPI
• Subjects: anticancer; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antitumor activity; bioinorganic chemistry; Biomolecules; Cancer therapies; Catalysis; Catalytic activity; catalytic drugs; Cell Line, Tumor; Cell Survival - drug effects; Cisplatin - pharmacology; Cytotoxicity; Gene expression; Glutathione - chemistry; half-sandwich complexes; Homeostasis; Humans; Hydrogenation; Indole; Indoles; Indoles - chemical synthesis; Indoles - chemistry; Indoles - pharmacology; Inhibitory Concentration 50; Kinetics; Ligands; Metabolism; Metal complexes; Metals; Molecular Conformation; NAD - chemistry; NADH; Nicotinamide adenine dinucleotide; Ovarian cancer; Oxidation; Oxidative stress; Prostate; Proton Magnetic Resonance Spectroscopy; Silver; Solutions; Spectrophotometry, Ultraviolet; Tumor cell lines; half-sandwich complexes; catalytic drugs; Indole; anticancer; bioinorganic chemistry

The synthesis, characterisation and evaluation of the in vitro cytotoxicity of four indole-based half-sandwich metal complexes towards two ovarian cancer cell lines (A2780 and A2780cisR) and one normal prostate cell line (PNT2) are presented herein. Although capable of inducing catalytic oxidation o...