Alterations in interhemispheric gamma-band connectivity are related to the emergence of auditory verbal hallucinations in healthy subjects during NMDA-receptor blockade

• Published in: Neuropsychopharmacology (New York, N.Y.) Vol. 43; no. 7; pp. 1608 - 1615
• Main Authors: Thiebes, Stephanie, Steinmann, Saskia, Curic, Stjepan, Polomac, Nenad, Andreou, Christina, Eichler, Iris-Carola, Eichler, Lars, Zöllner, Christian, Gallinat, Jürgen, Leicht, Gregor, Mulert, Christoph
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.06.2018; Springer International Publishing
• Subjects: Adolescent; Adult; Auditory perception; Auditory Perception - drug effects; Cerebral hemispheres; Connectivity; Cross-Over Studies; Dichotic Listening Tests; EEG; Electroencephalography - drug effects; Gamma Rhythm - drug effects; Glutamic acid receptors (ionotropic); Hallucinations; Hallucinations - chemically induced; Handedness; Healthy Volunteers; Humans; Ketamine; Ketamine - pharmacology; Lipopolysaccharides; Male; Mental disorders; N-Methyl-D-aspartic acid receptors; Psychopathology; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Schizophrenia; Single-Blind Method; Synchronization; Young Adult

Auditory verbal hallucinations (AVH) are a common positive symptom of schizophrenia. Excitatory-to-inhibitory (E/I) imbalance related to disturbed N-methyl-D-aspartate receptor (NMDAR) functioning has been suggested as a possible mechanism underlying altered connectivity and AVH in schizophrenia. Th...