Isolation and characterization of the nikR gene encoding a nickel-responsive regulator in Escherichia coli
Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By using random transposon Tn10 insertion, we isolated mutants in which expression of the nik operon became constitutive with respect to nickel. We have...
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Published in | Journal of bacteriology Vol. 181; no. 2; pp. 670 - 674 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
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United States
American Society for Microbiology
01.01.1999
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Series | Note |
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Abstract | Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By using random transposon Tn10 insertion, we isolated mutants in which expression of the nik operon became constitutive with respect to nickel. We have identified the corresponding nikR gene which encodes a nickel-responsive regulator. Expression of nikR was partially controlled by Fnr through transcription from the nikA promoter region. In addition, a specific transcription start site for the constitutive expression of nikR was found 51 bp upstream of the nikR gene. |
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AbstractList | Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By using random transposon Tn10 insertion, we isolated mutants in which expression of the nik operon became constitutive with respect to nickel. Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By using random transposon Tn10 insertion, we isolated mutants in which expression of the nik operon became constitutive with respect to nickel. We have identified the corresponding nikR gene which encodes a nickel-responsive regulator. Expression of nikR was partially controlled by Fnr through transcription from the nikA promoter region. In addition, a specific transcription start site for the constitutive expression of nikR was found 51 bp upstream of the nikR gene. ABSTRACT Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By using random transposon Tn 10 insertion, we isolated mutants in which expression of the nik operon became constitutive with respect to nickel. We have identified the corresponding nikR gene which encodes a nickel-responsive regulator. Expression of nikR was partially controlled by Fnr through transcription from the nikA promoter region. In addition, a specific transcription start site for the constitutive expression of nikR was found 51 bp upstream of the nikR gene. Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By using random transposon Tn 10 insertion, we isolated mutants in which expression of the nik operon became constitutive with respect to nickel. We have identified the corresponding nikR gene which encodes a nickel-responsive regulator. Expression of nikR was partially controlled by Fnr through transcription from the nikA promoter region. In addition, a specific transcription start site for the constitutive expression of nikR was found 51 bp upstream of the nikR gene. |
Author | Wu, L F Mandrand-Berthelot, M A Giordano, G De Pina, K Desjardin, V |
AuthorAffiliation | Laboratoire de Génétique Moléculaire des Microorganismes et des Interactions Cellulaires, CNRS UMR5577, Institut National des Sciences Appliquées, 69621 Villeurbanne Cedex, 1 and Laboratoire de Chimie Bactérienne, CNRS UPR9043, Institut de Biologie Structurale et Microbiologie, 13402 Marseille Cedex 20, 2 France |
AuthorAffiliation_xml | – name: Laboratoire de Génétique Moléculaire des Microorganismes et des Interactions Cellulaires, CNRS UMR5577, Institut National des Sciences Appliquées, 69621 Villeurbanne Cedex, 1 and Laboratoire de Chimie Bactérienne, CNRS UPR9043, Institut de Biologie Structurale et Microbiologie, 13402 Marseille Cedex 20, 2 France |
Author_xml | – sequence: 1 givenname: K surname: De Pina fullname: De Pina, K organization: Laboratoire de Génétique Moléculaire des Microorganismes et des Interactions Cellulaires, CNRS UMR5577, Institut National des Sciences Appliquées, 69621 Villeurbanne Cedex, France – sequence: 2 givenname: V surname: Desjardin fullname: Desjardin, V – sequence: 3 givenname: M A surname: Mandrand-Berthelot fullname: Mandrand-Berthelot, M A – sequence: 4 givenname: G surname: Giordano fullname: Giordano, G – sequence: 5 givenname: L F surname: Wu fullname: Wu, L F |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/9882686$$D View this record in MEDLINE/PubMed |
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Snippet | Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By using... ABSTRACT Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By... Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By using... |
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SubjectTerms | Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Base Sequence beta-Galactosidase - biosynthesis DNA Transposable Elements Enzymes Escherichia coli Escherichia coli - drug effects Escherichia coli - genetics Escherichia coli - metabolism Escherichia coli Proteins Gene Expression Regulation, Bacterial Genes Genetic Complementation Test Genetics and Molecular Biology Iron-Sulfur Proteins - metabolism Mutagenesis, Insertional Nickel Nickel - pharmacology Operon Proteins Recombinant Fusion Proteins - biosynthesis Repressor Proteins - genetics Restriction Mapping Transcription Factors - metabolism Transcription, Genetic |
Title | Isolation and characterization of the nikR gene encoding a nickel-responsive regulator in Escherichia coli |
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