Isolation and characterization of the nikR gene encoding a nickel-responsive regulator in Escherichia coli

Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By using random transposon Tn10 insertion, we isolated mutants in which expression of the nik operon became constitutive with respect to nickel. We have...

Full description

Saved in:
Bibliographic Details
Published inJournal of bacteriology Vol. 181; no. 2; pp. 670 - 674
Main Authors De Pina, K, Desjardin, V, Mandrand-Berthelot, M A, Giordano, G, Wu, L F
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.01.1999
SeriesNote
Subjects
Bacterial Proteins - biosynthesis
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacteriology
Base Sequence
beta-Galactosidase - biosynthesis
DNA Transposable Elements
Enzymes
Escherichia coli
Escherichia coli - drug effects
Escherichia coli - genetics
Escherichia coli - metabolism
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Genes
Genetic Complementation Test
Genetics and Molecular Biology
Iron-Sulfur Proteins - metabolism
Mutagenesis, Insertional
Nickel
Nickel - pharmacology
Operon
Proteins
Recombinant Fusion Proteins - biosynthesis
Repressor Proteins - genetics
Restriction Mapping
Transcription Factors - metabolism
Transcription, Genetic
Online AccessGet full text

Cover

Abstract Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By using random transposon Tn10 insertion, we isolated mutants in which expression of the nik operon became constitutive with respect to nickel. We have identified the corresponding nikR gene which encodes a nickel-responsive regulator. Expression of nikR was partially controlled by Fnr through transcription from the nikA promoter region. In addition, a specific transcription start site for the constitutive expression of nikR was found 51 bp upstream of the nikR gene.
AbstractList Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By using random transposon Tn10 insertion, we isolated mutants in which expression of the nik operon became constitutive with respect to nickel.
Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By using random transposon Tn10 insertion, we isolated mutants in which expression of the nik operon became constitutive with respect to nickel. We have identified the corresponding nikR gene which encodes a nickel-responsive regulator. Expression of nikR was partially controlled by Fnr through transcription from the nikA promoter region. In addition, a specific transcription start site for the constitutive expression of nikR was found 51 bp upstream of the nikR gene.
ABSTRACT Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By using random transposon Tn 10 insertion, we isolated mutants in which expression of the nik operon became constitutive with respect to nickel. We have identified the corresponding nikR gene which encodes a nickel-responsive regulator. Expression of nikR was partially controlled by Fnr through transcription from the nikA promoter region. In addition, a specific transcription start site for the constitutive expression of nikR was found 51 bp upstream of the nikR gene.
Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By using random transposon Tn 10 insertion, we isolated mutants in which expression of the nik operon became constitutive with respect to nickel. We have identified the corresponding nikR gene which encodes a nickel-responsive regulator. Expression of nikR was partially controlled by Fnr through transcription from the nikA promoter region. In addition, a specific transcription start site for the constitutive expression of nikR was found 51 bp upstream of the nikR gene.
Author Wu, L F
Mandrand-Berthelot, M A
Giordano, G
De Pina, K
Desjardin, V
AuthorAffiliation Laboratoire de Génétique Moléculaire des Microorganismes et des Interactions Cellulaires, CNRS UMR5577, Institut National des Sciences Appliquées, 69621 Villeurbanne Cedex, 1 and Laboratoire de Chimie Bactérienne, CNRS UPR9043, Institut de Biologie Structurale et Microbiologie, 13402 Marseille Cedex 20, 2 France
AuthorAffiliation_xml – name: Laboratoire de Génétique Moléculaire des Microorganismes et des Interactions Cellulaires, CNRS UMR5577, Institut National des Sciences Appliquées, 69621 Villeurbanne Cedex, 1 and Laboratoire de Chimie Bactérienne, CNRS UPR9043, Institut de Biologie Structurale et Microbiologie, 13402 Marseille Cedex 20, 2 France
Author_xml – sequence: 1
  givenname: K
  surname: De Pina
  fullname: De Pina, K
  organization: Laboratoire de Génétique Moléculaire des Microorganismes et des Interactions Cellulaires, CNRS UMR5577, Institut National des Sciences Appliquées, 69621 Villeurbanne Cedex, France
– sequence: 2
  givenname: V
  surname: Desjardin
  fullname: Desjardin, V
– sequence: 3
  givenname: M A
  surname: Mandrand-Berthelot
  fullname: Mandrand-Berthelot, M A
– sequence: 4
  givenname: G
  surname: Giordano
  fullname: Giordano, G
– sequence: 5
  givenname: L F
  surname: Wu
  fullname: Wu, L F
BackLink https://www.ncbi.nlm.nih.gov/pubmed/9882686$$D View this record in MEDLINE/PubMed
BookMark eNqNkVFrFDEUhYNU6rb6EwrBB99mzE1mMgn4Yku1LQVB9DlkM3d2s51N1mSmUH-9WXYp1ScDIXBzzuHe-52RkxADEnIBrAbg6uPdZQ0Kal7LjlWya2rQWr8iC2BaVW0r2AlZMMah0qDFG3KW84YxaJqWn5JTrRSXSi7I5jbH0U4-BmpDT93aJusmTP73oRgHOq2RBv_wna4wIMXgYu_DitpSdA84VgnzLobsH5EmXM0lLSbqA73Obl2C3Npb6uLo35LXgx0zvju-5-Tnl-sfVzfV_bevt1ef7yvXaDFVnLtOYQdWCeg1KCk77IeuBSeYkwoaUI0VuGSglLNNt-yHvhNLbplExXstzsmnQ-5uXm6xdximZEezS35r05OJ1pu_f4Jfm1V8NFo0XBb7h6M9xV8z5slsfXY4jjZgnLOBDmQ5_H-ELXCxT3z_j3AT5xTKDgznHZOCt_uu24PIpZhzwuG5YWBmD9zcXZoC3HBTgJfbmD3w4rt4Oe2z60hY_AHpPapY
CODEN JOBAAY
CitedBy_id crossref_primary_10_1007_s00203_008_0356_8
crossref_primary_10_1039_C5MT00072F
crossref_primary_10_1371_journal_pone_0030421
crossref_primary_10_1074_jbc_M110_196055
crossref_primary_10_1021_bi100947k
crossref_primary_10_1021_bi300981m
crossref_primary_10_1128_IAI_69_8_4891_4897_2001
crossref_primary_10_1111_j_1574_695X_2007_00244_x
crossref_primary_10_1021_bi2014882
crossref_primary_10_1074_jbc_M411799200
crossref_primary_10_1110_ps_8_11_2494
crossref_primary_10_1016_j_ccr_2011_06_014
crossref_primary_10_1099_mic_0_062976_0
crossref_primary_10_1021_bi062092w
crossref_primary_10_1128_JB_182_6_1507_1514_2000
crossref_primary_10_1021_cr4004665
crossref_primary_10_1074_jbc_M307941200
crossref_primary_10_1021_cr900010n
crossref_primary_10_1021_ja909136h
crossref_primary_10_1021_ja0685102
crossref_primary_10_7717_peerj_12230
crossref_primary_10_1021_bi200737a
crossref_primary_10_1128_IAI_72_2_766_773_2004
crossref_primary_10_1093_nar_gkr460
crossref_primary_10_1186_s12864_017_3957_2
crossref_primary_10_1016_j_biochi_2006_07_016
crossref_primary_10_1016_S0168_6445_03_00042_1
crossref_primary_10_1016_j_jmb_2008_08_066
crossref_primary_10_1021_ic900778k
crossref_primary_10_1074_jbc_M800591200
crossref_primary_10_1007_s11356_015_5580_6
crossref_primary_10_1021_bi700183u
crossref_primary_10_1021_bi801051y
crossref_primary_10_1128_JB_01153_10
crossref_primary_10_1128_IAI_73_10_6437_6445_2005
crossref_primary_10_1021_acs_inorgchem_9b01096
crossref_primary_10_1128_JB_181_23_7381_7384_1999
crossref_primary_10_1128_ecosalplus_5_4_4_3
crossref_primary_10_1021_acs_inorgchem_7b00527
crossref_primary_10_1046_j_1365_2958_2003_03621_x
crossref_primary_10_1093_mtomcs_mfac094
crossref_primary_10_1021_ja104118r
crossref_primary_10_1021_acs_biochem_5b01328
crossref_primary_10_1074_jbc_M211740200
crossref_primary_10_1111_j_1523_5378_2009_00685_x
crossref_primary_10_1128_IAI_73_10_6727_6735_2005
crossref_primary_10_1021_bi9013352
crossref_primary_10_1016_j_celrep_2023_112518
crossref_primary_10_1039_b818167p
crossref_primary_10_1073_pnas_0606247103
crossref_primary_10_1128_JB_183_2_426_434_2001
crossref_primary_10_1016_S1074_5521_02_00241_7
crossref_primary_10_1099_mic_0_000702
crossref_primary_10_1039_b719676h
crossref_primary_10_1128_AEM_02171_08
crossref_primary_10_1128_JB_01190_06
crossref_primary_10_1016_S0167_4781_00_00178_0
crossref_primary_10_1039_C4MT00293H
crossref_primary_10_1128_JB_00152_10
crossref_primary_10_1128_EC_2_5_995_1002_2003
crossref_primary_10_3390_inorganics7080104
crossref_primary_10_1039_b906683g
crossref_primary_10_1128_IAI_70_6_2846_2852_2002
crossref_primary_10_1021_cr800557s
crossref_primary_10_1021_cr900077w
crossref_primary_10_1590_0074_02760230086
crossref_primary_10_2217_fmb_14_87
crossref_primary_10_1074_jbc_M002232200
crossref_primary_10_3390_molecules200814265
crossref_primary_10_1128_jb_00080_24
crossref_primary_10_1128_JB_00854_09
crossref_primary_10_1128_JB_184_20_5706_5713_2002
crossref_primary_10_1007_s10534_006_9028_9
crossref_primary_10_1007_s00775_005_0008_2
crossref_primary_10_1128_IAI_01196_06
crossref_primary_10_1021_bi801481j
crossref_primary_10_1128_JB_188_4_1245_1250_2006
crossref_primary_10_1111_j_1365_2958_2006_05065_x
crossref_primary_10_1093_nar_gkp1216
crossref_primary_10_1016_j_jmb_2008_03_010
crossref_primary_10_1021_cr050196r
crossref_primary_10_1196_annals_1419_014
crossref_primary_10_1016_j_envint_2019_105339
crossref_primary_10_1128_ecosalplus_3_5_4
crossref_primary_10_1007_s10534_005_3716_8
crossref_primary_10_1039_c1mt00063b
crossref_primary_10_1007_s00438_006_0117_9
crossref_primary_10_1128_JB_05032_11
crossref_primary_10_1002_ejic_201800602
crossref_primary_10_1016_j_cbpa_2006_02_011
crossref_primary_10_1021_bi100685k
crossref_primary_10_1016_j_jmb_2006_06_058
crossref_primary_10_1111_hel_12386
crossref_primary_10_1128_IAI_01188_06
crossref_primary_10_1016_j_bpc_2011_03_010
crossref_primary_10_1021_bi049405c
crossref_primary_10_1021_bi300510z
crossref_primary_10_1074_jbc_M702982200
crossref_primary_10_1007_s13206_014_9107_x
crossref_primary_10_1128_JB_185_23_6773_6779_2003
crossref_primary_10_1128_JB_188_1_317_327_2006
crossref_primary_10_1093_mtomcs_mfac058
crossref_primary_10_1128_IAI_73_11_7252_7258_2005
crossref_primary_10_1021_bi300886q
crossref_primary_10_1074_jbc_M512312200
crossref_primary_10_1016_j_tim_2004_09_005
crossref_primary_10_1016_j_tube_2012_08_003
crossref_primary_10_1371_journal_pone_0109660
crossref_primary_10_1007_s10534_006_9039_6
crossref_primary_10_1016_j_jinorgbio_2022_111713
crossref_primary_10_1128_JB_187_12_3909_3912_2005
crossref_primary_10_1016_j_jmb_2005_03_017
crossref_primary_10_1016_S1074_5521_02_00251_X
crossref_primary_10_3389_fcimb_2015_00091
crossref_primary_10_1016_j_jinorgbio_2005_10_014
crossref_primary_10_1128_aem_00991_23
crossref_primary_10_1128_jb_00031_24
crossref_primary_10_1021_ja300834b
crossref_primary_10_1016_j_jbiotec_2006_03_045
crossref_primary_10_1128_ecosalplus_esp_0011_2016
crossref_primary_10_1128_AEM_02684_20
crossref_primary_10_1529_biophysj_107_115576
crossref_primary_10_1039_C5MT00324E
Cites_doi 10.1128/jb.171.5.2609-2613.1989
10.1042/bj3180889
10.1016/0966-842X(93)90036-Q
10.1111/j.1365-2958.1993.tb01247.x
10.1128/mr.51.1.22-42.1987
10.1128/mr.56.1.195-228.1992
10.1111/j.1365-2958.1989.tb00156.x
10.1093/genetics/54.2.405
10.1128/jb.169.6.2624-2630.1987
10.1016/0923-2508(94)90092-2
10.1111/j.1365-2958.1994.tb01280.x
10.1016/S0065-2164(08)70358-7
10.1073/pnas.82.4.1074
10.1006/plas.1994.1032
10.1016/0378-1119(91)90294-L
10.1016/0378-1119(84)90012-X
10.1093/nar/22.13.2576
10.1111/j.1432-1033.1995.tb20211.x
10.1016/S0300-9084(86)81081-1
ContentType Journal Article
Copyright Copyright American Society for Microbiology Jan 1999
Copyright © 1999, American Society for Microbiology 1999
Copyright_xml – notice: Copyright American Society for Microbiology Jan 1999
– notice: Copyright © 1999, American Society for Microbiology 1999
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
7QL
7TM
7U9
8FD
C1K
FR3
H94
M7N
P64
RC3
5PM
DOI 10.1128/JB.181.2.670-674.1999
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
Bacteriology Abstracts (Microbiology B)
Nucleic Acids Abstracts
Virology and AIDS Abstracts
Technology Research Database
Environmental Sciences and Pollution Management
Engineering Research Database
AIDS and Cancer Research Abstracts
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biotechnology and BioEngineering Abstracts
Genetics Abstracts
PubMed Central (Full Participant titles)
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Genetics Abstracts
Virology and AIDS Abstracts
Technology Research Database
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
Nucleic Acids Abstracts
AIDS and Cancer Research Abstracts
Engineering Research Database
Biotechnology and BioEngineering Abstracts
Environmental Sciences and Pollution Management
DatabaseTitleList Genetics Abstracts
MEDLINE
Genetics Abstracts
CrossRef

Genetics Abstracts
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1098-5530
EndPage 674
ExternalDocumentID 38837496
10_1128_JB_181_2_670_674_1999
9882686
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
-DZ
-~X
.55
.GJ
0R~
186
18M
1VV
29J
2WC
39C
3O-
4.4
53G
5GY
5RE
5VS
79B
85S
8WZ
9M8
A6W
ABPPZ
ABTAH
ACGFO
ACGOD
ACNCT
ACPRK
ADBBV
AENEX
AFFDN
AFFNX
AFRAH
AGCDD
AGVNZ
AI.
AIDAL
AJUXI
ALMA_UNASSIGNED_HOLDINGS
AOIJS
BAWUL
BKOMP
BTFSW
C1A
CGR
CJ0
CS3
CUY
CVF
DIK
DU5
E3Z
EBS
ECM
EIF
EJD
F20
F5P
FRP
GX1
H13
HYE
HZ~
IH2
KQ8
L7B
MVM
NHB
NPM
O9-
OHT
OK1
P-S
P2P
PQQKQ
QZG
RHF
RHI
RNS
RPM
RSF
RXW
TAE
TR2
UCJ
UHB
UKR
UPT
VH1
VQA
W8F
WH7
WHG
WOQ
X7M
Y6R
YQT
YR2
YZZ
ZCA
ZCG
ZGI
ZXP
ZY4
~02
~KM
AAYXX
CITATION
7QL
7TM
7U9
8FD
C1K
FR3
H94
M7N
P64
RC3
AFMIJ
5PM
ID FETCH-LOGICAL-c493t-22c78e71a831d918667edf751c30c6814184a3eb0188ca47bdfd73b2a06e82d93
IEDL.DBID RPM
ISSN 0021-9193
IngestDate Tue Sep 17 21:13:31 EDT 2024
Fri Aug 16 22:05:50 EDT 2024
Fri Aug 16 03:45:28 EDT 2024
Thu Oct 10 19:32:19 EDT 2024
Thu Sep 12 16:45:21 EDT 2024
Sat Sep 28 07:43:10 EDT 2024
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Language English
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c493t-22c78e71a831d918667edf751c30c6814184a3eb0188ca47bdfd73b2a06e82d93
Notes ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Corresponding author. Mailing address: Laboratoire de Chimie Bactérienne, UPR9043, Institut de Biologie Structurale et Microbiologie, CNRS, 31 chemin Joseph Aiguier, 13402 Marseille Cedex 20, France. Phone: (33) 4 91 16 44 31. Fax: (33) 4 91 71 89 14. E-mail: wu@ibsm.cnrs-mrs.fr.
OpenAccessLink https://jb.asm.org/content/jb/181/2/670.full.pdf
PMID 9882686
PQID 227063259
PQPubID 23462
PageCount 5
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_93426
proquest_miscellaneous_17166662
proquest_miscellaneous_17151236
proquest_journals_227063259
crossref_primary_10_1128_JB_181_2_670_674_1999
pubmed_primary_9882686
PublicationCentury 1900
PublicationDate 1999-01-01
PublicationDateYYYYMMDD 1999-01-01
PublicationDate_xml – month: 01
  year: 1999
  text: 1999-01-01
  day: 01
PublicationDecade 1990
PublicationPlace United States
PublicationPlace_xml – name: United States
– name: Washington
PublicationSeriesTitle Note
PublicationTitle Journal of bacteriology
PublicationTitleAlternate J Bacteriol
PublicationYear 1999
Publisher American Society for Microbiology
Publisher_xml – name: American Society for Microbiology
References 1579110 - Microbiol Rev. 1992 Mar;56(1):195-228
2695744 - Mol Microbiol. 1989 Dec;3(12):1709-18
3089308 - Biochimie. 1986 Jan;68(1):167-79
8159980 - Scand J Work Environ Health. 1993;19 Suppl 1:75-80
8836134 - Biochem J. 1996 Sep 15;318 ( Pt 3):889-96
3156376 - Proc Natl Acad Sci U S A. 1985 Feb;82(4):1074-8
871439 - Br J Ind Med. 1977 May;34(2):102-5
7934931 - Mol Microbiol. 1993 Sep;9(6):1181-91
6099322 - Gene. 1984 Dec;32(3):369-79
1323505 - FEMS Microbiol Lett. 1992 Jun 15;72(3):243-7
7830565 - Mol Microbiol. 1994 Oct;14(2):191-7
7867647 - Eur J Biochem. 1995 Feb 1;227(3):857-65
8058823 - Plasmid. 1994 May;31(3):300-7
5338813 - Genetics. 1966 Aug;54(2):405-10
6650263 - Adv Appl Microbiol. 1983;29:195-265
3104749 - Microbiol Rev. 1987 Mar;51(1):22-42
8041620 - Nucleic Acids Res. 1994 Jul 11;22(13):2576-86
8044465 - Trends Microbiol. 1993 May;1(2):66-9
3294800 - J Bacteriol. 1987 Jun;169(6):2624-30
2651408 - J Bacteriol. 1989 May;171(5):2609-13
7843119 - Environ Health Perspect. 1994 Sep;102 Suppl 3:297-300
1743519 - Gene. 1991 Oct 30;107(1):37-42
7855430 - Res Microbiol. 1994 Jun-Aug;145(5-6):437-50
Doll R. (e_1_3_2_6_2) 1977; 34
e_1_3_2_26_2
Bardonnet N. (e_1_3_2_3_2) 1992; 72
Navarro C. (e_1_3_2_12_2) 1993; 9
Tabor S. (e_1_3_2_18_2) 1985; 82
e_1_3_2_20_2
de Pina K. (e_1_3_2_5_2) 1995; 227
Youn H. D. (e_1_3_2_27_2) 1996; 318
Gunsalus R. P. (e_1_3_2_7_2) 1994; 145
Way J. C. (e_1_3_2_21_2) 1984; 32
Tao X. (e_1_3_2_19_2) 1994; 14
e_1_3_2_15_2
e_1_3_2_8_2
Babich H. (e_1_3_2_2_2) 1983; 29
Wu L.-F. (e_1_3_2_25_2) 1991; 107
Sofia H. J. (e_1_3_2_16_2) 1994; 22
Wu L.-F. (e_1_3_2_23_2) 1989; 3
Maneewannakul S. (e_1_3_2_9_2) 1994; 31
Wu L.-F. (e_1_3_2_24_2) 1994; 102
e_1_3_2_10_2
e_1_3_2_11_2
e_1_3_2_4_2
e_1_3_2_14_2
Wu L.-F. (e_1_3_2_22_2) 1986; 68
Payne S. M. (e_1_3_2_13_2) 1993; 1
Sunderman F. W. (e_1_3_2_17_2) 1993; 19
References_xml – ident: e_1_3_2_14_2
  doi: 10.1128/jb.171.5.2609-2613.1989
– volume: 19
  start-page: 75
  year: 1993
  ident: e_1_3_2_17_2
  article-title: Search for molecular mechanisms in the genotoxicity of nickel
  publication-title: Scand. J. Work Environ. Health
  contributor:
    fullname: Sunderman F. W.
– volume: 102
  start-page: 297
  year: 1994
  ident: e_1_3_2_24_2
  article-title: Antagonistic effect of nickel on the fermentative growth of Escherichia coli K-12 and comparison of nickel and cobalt toxicity on the aerobic and anaerobic growth
  publication-title: Environ. Health Perspect.
  contributor:
    fullname: Wu L.-F.
– volume: 318
  start-page: 889
  year: 1996
  ident: e_1_3_2_27_2
  article-title: A novel nickel-containing superoxide dismutase from Streptomyces spp
  publication-title: Biochem. J.
  doi: 10.1042/bj3180889
  contributor:
    fullname: Youn H. D.
– volume: 1
  start-page: 66
  year: 1993
  ident: e_1_3_2_13_2
  article-title: Iron acquisition in microbial pathogenesis
  publication-title: Trends Microbiol.
  doi: 10.1016/0966-842X(93)90036-Q
  contributor:
    fullname: Payne S. M.
– volume: 9
  start-page: 1181
  year: 1993
  ident: e_1_3_2_12_2
  article-title: The nik operon of Escherichia coli encodes a periplasmic binding-protein-dependent transport system for nickel
  publication-title: Mol. Microbiol.
  doi: 10.1111/j.1365-2958.1993.tb01247.x
  contributor:
    fullname: Navarro C.
– ident: e_1_3_2_20_2
– ident: e_1_3_2_8_2
  doi: 10.1128/mr.51.1.22-42.1987
– ident: e_1_3_2_15_2
  doi: 10.1128/mr.56.1.195-228.1992
– volume: 3
  start-page: 1709
  year: 1989
  ident: e_1_3_2_23_2
  article-title: Nickel deficiency gives rise to the defective hydrogenase phenotype of hydC and fnr mutants in Escherichia coli
  publication-title: Mol. Microbiol.
  doi: 10.1111/j.1365-2958.1989.tb00156.x
  contributor:
    fullname: Wu L.-F.
– volume: 72
  start-page: 243
  year: 1992
  ident: e_1_3_2_3_2
  article-title: ′uidA-antibiotic-resistance cassettes for insertion mutagenesis, gene fusions and genetic constructions
  publication-title: FEMS Microbiol. Lett.
  contributor:
    fullname: Bardonnet N.
– ident: e_1_3_2_26_2
  doi: 10.1093/genetics/54.2.405
– ident: e_1_3_2_4_2
  doi: 10.1128/jb.169.6.2624-2630.1987
– ident: e_1_3_2_11_2
– volume: 145
  start-page: 437
  year: 1994
  ident: e_1_3_2_7_2
  article-title: Aerobic-anaerobic gene regulation in Escherichia coli: control by the ArcAB and Fnr regulons
  publication-title: Res. Microbiol.
  doi: 10.1016/0923-2508(94)90092-2
  contributor:
    fullname: Gunsalus R. P.
– volume: 14
  start-page: 191
  year: 1994
  ident: e_1_3_2_19_2
  article-title: Iron, DtxR, and the regulation of diphtheria toxin expression
  publication-title: Mol. Microbiol.
  doi: 10.1111/j.1365-2958.1994.tb01280.x
  contributor:
    fullname: Tao X.
– volume: 34
  start-page: 102
  year: 1977
  ident: e_1_3_2_6_2
  article-title: Cancers of the lung and nasal sinuses in nickel workers: a reassessment of the period of risk
  publication-title: Br. J. Ind. Med.
  contributor:
    fullname: Doll R.
– volume: 29
  start-page: 195
  year: 1983
  ident: e_1_3_2_2_2
  article-title: Toxicity of nickel to microbes: environmental aspects
  publication-title: Adv. Appl. Microbiol.
  doi: 10.1016/S0065-2164(08)70358-7
  contributor:
    fullname: Babich H.
– volume: 82
  start-page: 1074
  year: 1985
  ident: e_1_3_2_18_2
  article-title: A bacteriophage T7 RNA polymerase/promoter system for controlled exclusive expression of specific genes
  publication-title: Proc. Natl. Acad. Sci. USA
  doi: 10.1073/pnas.82.4.1074
  contributor:
    fullname: Tabor S.
– volume: 31
  start-page: 300
  year: 1994
  ident: e_1_3_2_9_2
  article-title: The pKSM710 vector cassette provides tightly regulated lac and T7lac promoters and strategies for manipulating N-terminal protein sequences
  publication-title: Plasmid
  doi: 10.1006/plas.1994.1032
  contributor:
    fullname: Maneewannakul S.
– ident: e_1_3_2_10_2
– volume: 107
  start-page: 37
  year: 1991
  ident: e_1_3_2_25_2
  article-title: The hydC region contains a multi-cistronic operon (nik) involved in nickel transport in Escherichia coli
  publication-title: Gene
  doi: 10.1016/0378-1119(91)90294-L
  contributor:
    fullname: Wu L.-F.
– volume: 32
  start-page: 369
  year: 1984
  ident: e_1_3_2_21_2
  article-title: New derivatives for transposon mutagenesis and for construction of lacZ operon fusions by transposition
  publication-title: Gene
  doi: 10.1016/0378-1119(84)90012-X
  contributor:
    fullname: Way J. C.
– volume: 22
  start-page: 2576
  year: 1994
  ident: e_1_3_2_16_2
  article-title: Analysis of the Escherichia coli genome. V. DNA sequence of the region from 76.0 to 81.5 minutes
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/22.13.2576
  contributor:
    fullname: Sofia H. J.
– volume: 227
  start-page: 857
  year: 1995
  ident: e_1_3_2_5_2
  article-title: Purification and characterization of the periplasmic nickel-binding protein NikA of Escherichia coli K12
  publication-title: Eur. J. Biochem.
  doi: 10.1111/j.1432-1033.1995.tb20211.x
  contributor:
    fullname: de Pina K.
– volume: 68
  start-page: 167
  year: 1986
  ident: e_1_3_2_22_2
  article-title: Genetic and physiological characterization of new Escherichia coli mutants impaired in hydrogenase activity
  publication-title: Biochimie
  doi: 10.1016/S0300-9084(86)81081-1
  contributor:
    fullname: Wu L.-F.
SSID ssj0014452
Score 2.0458257
Snippet Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By using...
ABSTRACT Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By...
Expression of the nickel-specific transport system encoded by the Escherichia coli nikABCDE operon is repressed by a high concentration of nickel. By using...
SourceID pubmedcentral
proquest
crossref
pubmed
SourceType Open Access Repository
Aggregation Database
Index Database
StartPage 670
SubjectTerms Bacterial Proteins - biosynthesis
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Bacteriology
Base Sequence
beta-Galactosidase - biosynthesis
DNA Transposable Elements
Enzymes
Escherichia coli
Escherichia coli - drug effects
Escherichia coli - genetics
Escherichia coli - metabolism
Escherichia coli Proteins
Gene Expression Regulation, Bacterial
Genes
Genetic Complementation Test
Genetics and Molecular Biology
Iron-Sulfur Proteins - metabolism
Mutagenesis, Insertional
Nickel
Nickel - pharmacology
Operon
Proteins
Recombinant Fusion Proteins - biosynthesis
Repressor Proteins - genetics
Restriction Mapping
Transcription Factors - metabolism
Transcription, Genetic
Title Isolation and characterization of the nikR gene encoding a nickel-responsive regulator in Escherichia coli
URI https://www.ncbi.nlm.nih.gov/pubmed/9882686
https://www.proquest.com/docview/227063259
https://search.proquest.com/docview/17151236
https://search.proquest.com/docview/17166662
https://pubmed.ncbi.nlm.nih.gov/PMC93426
Volume 181
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Na9wwEB26gUAupU0b6qZNdejVXluSLeuYLJumCyllaWBvwvpY6iaRQ3YTyL_PyNYuSQs95GAwSAajN_K88cw8AXw1ZUiv6dD2ITFAsblL0Y3gnUY2wnJbURm6kc9_VGcXfLYoF7GPexXLKr3RbeavrjPf_u5rK2-uzXhTJzb-eT6RDP3KeAQjwdgmQI-JA87LKBBe4D6WLDbt4Fd4PDvJ0J1lNKtEqHjnoVFP7sGuRJJZhV7qp47pH7b5d9HkEy90-gZeR_pIjofXfAuvnN-H3eFAyYd38Oc7mlK_1qTxlky2asxDsyXplgQJH_Ht5ZwEwWky9aYL3os0BG3i0l2l81g0e-_IfDinvrslrSfTVYC3DaXRBI2nfQ8Xp9Nfk7M0nqaQGi7ZOqXUiNqJoqlZYWXQuRPOLkVZGJabqi44xnoNczov6to0XGi7tAJRbPLK1dRKdgA7vvPuAxDdWCZwckjpcedy6Wpea26FEVovNU8g2yyluhlEM1QfbNBazU4UoqCoQhTw4iqgkMDhZsFV3EMrRalA_oThWQJftqNo_CGj0XjX3a1UIQJhYdV_Z2CAVtEEDgb4ti8UYU-gfIbrdjzobj8fQXPs9bd78_v4wucOYW9Qfgh_cT7Bzvr2zn1GXrPWRzD6tiiOent-BGE6948
link.rule.ids 230,315,733,786,790,891,27955,27956,53825,53827
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3da9swEBdbR1lf9l3mdVv1sFc7tiRb1uMaUtKsKSOk0DdhfaTz0sqlSQbbX7-TLYe2g8H2YDCcDBb3O9-d7-4nhD7p3JfXlB_7EJCgmNTG4EbgTkE0QlNTEOGnkadnxficTS7yizDHvQptlU6rOnFX14mrv7W9lTfXetD3iQ2-ToeCgl8ZPEZPwFpJ3qfooXTAWB4owjOwZEHD2A58hweTowQcWkKSgvued-ZH9cQe2hUQZhZ-mvqua_oj3nzYNnnHDx0_R_N-B137yTLZrFWifz0gd_zHLb5Az0Jcij93wpfokXWv0G53UuXP1-j7CWC0VSKunMHDLc1zN8WJmwWGSBK7ejnDnskaj5xuvFvEFQawLe1VPAvduD8sntlLf2pYc4trh0crj5va91xjQGX9Bp0fj-bDcRyOaYg1E3QdE6J5aXlWlTQzwhPocWsWPM80TXVRZgySyIpalWZlqSvGlVkYDvCo0sKWxAi6j3Zc4-xbhFVlKIfFvlbIrE2FLVmpmOGaK7VQLEJJryF507FxyDaLIaWcHElQriQSlAsXk165ETro9SiDca4kIRwCM8j7InS4lYJV-VJJ5WyzWcmM-0iIFn9dAZlfQSK036Fi-0IBTRHK78FlK_eE3vclAIKW2LtV-rv_fO4QPR3Pp6fy9OTsywHa6-gl_K-i92hnfbuxHyB4WquPrbH8BgTMGDk
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBZtSkoufYe6aRsdevVLli3r2Gx3SbZNCEsDexPWw6m7ibxkdwvtr-_IlpckhR5yMBgkg81845mRvvmE0CeVu-016do-OBQoOjEhhBG4k5CNZIkuCHfdyKdnxfEFnc7zuV-6WHlapVWyiezVdWSbHx23cnmt4oEnFp-fjngGcSVe6jp-jJ6AxxI2lOl--4DS3MuEp-DNPPOtO_AvjqdHEQS1iEQFc7x36tr1-B7a5ZBqFq6j-nZ4-ifnvE-dvBWLJs_RfPiKnoKyiDZrGak_9wQeH_CZL9Azn5_iz_2El-iRsa_Qbn9i5e_X6OcJYLUzJq6sxqOt3HPfzYnbGkNGiW2zmGGnaI3HVrUuPOIKA-gW5iqceVbuL4Nn5tKdHtbe4Mbi8crhp3HcawzobN6gi8n4--g49Mc1hIrybB0SolhpWFqVWaq5E9JjRtcsT1WWqKJMKRSTVWZkkpalqiiTutYMYFIlhSmJ5tk-2rGtNW8RlpXOGEx2e4bUmISbkpaSaqaYlLWkAYoGK4llr8ohumqGlGJ6JMDAgggwMFxUOAMH6GCwpfBOuhKEMEjQoP4L0OF2FLzLbZlU1rSblUiZy4iy4r8zoAIsSID2e2RsX8gjKkD5Hchsx52w990RAEIn8N0Z_t0DnztET8-_TMS3k7OvB2ivV5lwK0bv0c76ZmM-QA61lh87f_kLyWkauQ
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Isolation+and+characterization+of+the+nikR+gene+encoding+a+nickel-responsive+regulator+in+Escherichia+coli&rft.jtitle=Journal+of+bacteriology&rft.au=De+Pina%2C+Karinne&rft.au=Desjardin%2C+Valerie&rft.au=Mandrand-Berthelot%2C+Marie-Andree&rft.au=Giordano%2C+Gerard&rft.date=1999-01-01&rft.pub=American+Society+for+Microbiology&rft.issn=0021-9193&rft.eissn=1098-5530&rft.volume=181&rft.issue=2&rft.spage=670&rft_id=info:doi/10.1128%2FJB.181.2.670-674.1999&rft.externalDBID=NO_FULL_TEXT&rft.externalDocID=38837496
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0021-9193&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0021-9193&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0021-9193&client=summon