Accuracy of serum procalcitonin for the diagnosis of sepsis in neonates and children with systemic inflammatory syndrome: a meta-analysis

• Published in: BMC infectious diseases Vol. 17; no. 1; pp. 302 - 12
• Main Authors: Pontrelli, Giuseppe, De Crescenzo, Franco, Buzzetti, Roberto, Jenkner, Alessandro, Balduzzi, Sara, Calò Carducci, Francesca, Amodio, Donato, De Luca, Maia, Chiurchiù, Sara, Davies, Elin Haf, Copponi, Giorgia, Simonetti, Alessandra, Ferretti, Elena, Di Franco, Valeria, Rasi, Virginia, Della Corte, Martina, Gramatica, Luca, Ciabattini, Marco, Livadiotti, Susanna, Rossi, Paolo
• Format: Journal Article
• Language: English
• Published: England BioMed Central 24.04.2017; BMC
• Subjects: Accuracy; Adults; Age; Bacterial infections; Biomarkers; Biomarkers - blood; Bivariate analysis; Calcitonin - blood; Child; Child, Preschool; Children; Confidence intervals; Cytokines; Data processing; Diagnosis; Diagnostic systems; Heart rate; Heterogeneity; Humans; Infant; Infant, Newborn; Infections; Inflammation; Libraries; Mathematical analysis; Meta-analysis; Neonates; Patients; Pediatrics; Procalcitonin; Prospective Studies; Proteins; Reproducibility of Results; Sensitivity analysis; Sensitivity and Specificity; Sepsis; Sepsis - diagnosis; Sepsis - microbiology; Standard deviation; Studies; Systemic inflammatory response syndrome; Systemic inflammatory response syndrome; Procalcitonin; Infant; Sepsis; Biological markers; Child; Meta-analysis

A number of biomarkers have been studied for the diagnosis of sepsis in paediatrics, but no gold standard has been identified. Procalcitonin (PCT) was demonstrated to be an accurate biomarker for the diagnosis of sepsis in adults and showed to be promising in paediatrics. Our study reviewed the diag...