Metabolic N-Dealkylation and N-Oxidation as Elucidators of the Role of Alkylamino Moieties in Drugs Acting at Various Receptors

• Published in: Molecules (Basel, Switzerland) Vol. 26; no. 7; p. 1917
• Main Author: EH-Haj, Babiker M.
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 29.03.2021; MDPI
• Subjects: Amines - chemistry; Amines - pharmacology; Antidepressants; Biochemical Phenomena; Carbon; Dealkylation; Drugs; metabolic N-dealkylation; metabolic N-oxidation; Metabolism; Metabolites; N-alkylamino moieties; N-desalkylamino metabolite drugs; Obsessive compulsive disorder; Oxidation-Reduction; Pharmaceutical Preparations - chemistry; pharmacologic activity; Physicochemical properties; Review; Serotonin; N-desalkylamino metabolite drugs; metabolic N-oxidation; physicochemical properties; N-oxide metabolite prodrugs; N-alkylamino moieties; metabolic N-dealkylation; pharmacologic activity

Metabolic reactions that occur at alkylamino moieties may provide insight into the roles of these moieties when they are parts of drug molecules that act at different receptors. N-dealkylation of N,N-dialkylamino moieties has been associated with retaining, attenuation or loss of pharmacologic activ...