Identifying conserved molecular targets required for cell migration of glioblastoma cancer stem cells

• Published in: Cell death & disease Vol. 11; no. 2; p. 152
• Main Authors: Volovetz, Josephine, Berezovsky, Artem D, Alban, Tyler, Chen, Yujun, Lauko, Adam, Aranjuez, George F, Burtscher, Ashley, Shibuya, Kelly, Silver, Daniel J, Peterson, John, Manor, Danny, McDonald, Jocelyn A, Lathia, Justin D
• Format: Journal Article
• Language: English
• Published: England Springer Nature B.V 26.02.2020; Nature Publishing Group UK
• Subjects: Brain cancer; Brain Neoplasms - metabolism; Brain Neoplasms - pathology; Brain tumors; Cell adhesion & migration; Cell Line, Tumor; Cell migration; Cell Movement - genetics; Cell Movement - physiology; Cell Proliferation - physiology; Drosophila; Extracellular matrix; Gene expression; Gene Expression Regulation, Neoplastic - genetics; Genetic analysis; Genetic screening; Glioblastoma; Glioblastoma - diagnosis; Glioblastoma - metabolism; Glioblastoma - pathology; GTP-binding protein; Guanosine triphosphatases; Humans; Insects; Invasiveness; Metastases; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Neuroimaging; Parenchyma; Prognosis; Stem cells

Glioblastoma (GBM) is the most prevalent primary malignant brain tumor and is associated with extensive tumor cell infiltration into the adjacent brain parenchyma. However, there are limited targeted therapies that address this disease hallmark. While the invasive capacity of self-renewing cancer st...