A Novel Self-Emulsifying Drug Delivery System (SEDDS) Based on VESIsorb® Formulation Technology Improving the Oral Bioavailability of Cannabidiol in Healthy Subjects

• Published in: Molecules (Basel, Switzerland) Vol. 24; no. 16; p. 2967
• Main Authors: Knaub, Katharina, Sartorius, Tina, Dharsono, Tanita, Wacker, Roland, Wilhelm, Manfred, Schön, Christiane
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.08.2019; MDPI
• Subjects: Administration, Oral; Adult; Analgesics - blood; Analgesics - pharmacokinetics; Anti-Anxiety Agents - blood; Anti-Anxiety Agents - pharmacokinetics; Area Under Curve; Bioavailability; Biological Availability; Cannabidiol; Cannabidiol - blood; Cannabidiol - pharmacokinetics; Cannabis sativa; CBD; Cross-Over Studies; Double-Blind Method; Drug delivery systems; Drug Delivery Systems - methods; Drug dosages; Emulsifying Agents - administration & dosage; Emulsifying Agents - chemistry; Fasting; Female; Food; Gender; Healthy Volunteers; Hemp; hemp extract; human; Humans; Male; Marijuana; Metabolism; oral drug delivery system; pharmacokinetic; Pharmacokinetics; Plasma; SEDDS; Sex Factors; Tetrahydrocannabinol; THC; Vegetarianism; Women; cannabidiol; Cannabis sativa; hemp extract; SEDDS; CBD; bioavailability; oral drug delivery system; pharmacokinetic; human

Cannabidiol (CBD), a phytocannabinoid compound of Cannabis sativa, shows limited oral bioavailability due to its lipophilicity and extensive first-pass metabolism. CBD is also known for its high intra- and inter-subject absorption variability in humans. To overcome these limitations a novel self-emu...