Evaluation of [18F]Mefway Biodistribution and Dosimetry Based on Whole-Body PET Imaging of Mice

• Published in: Molecular imaging and biology Vol. 15; no. 2; pp. 222 - 229
• Main Authors: Constantinescu, Cristian C., Sevrioukov, Evgueni, Garcia, Adriana, Pan, Min-Liang, Mukherjee, Jogeshwar
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.04.2013; Springer Nature B.V
• Subjects: Animals; Computed tomography; Computer Simulation; Female; Fluorine Radioisotopes - pharmacokinetics; Humans; Imaging; Male; Medicine; Medicine & Public Health; Mice; Multimodal Imaging - methods; Piperazines - pharmacokinetics; Positron-Emission Tomography - methods; Pyridines - pharmacokinetics; Radiation Dosage; Radiology; Research Article; Tissue Distribution; Tomography, X-Ray Computed; Whole Body Imaging - methods; F]Mefway; [; Dosimetry; Preclinical; 5-HT; Biodistribution; PET; Whole-body

Purpose [ 18 F]Mefway is a novel radiotracer specific to the serotonin 5-HT 1A receptor class. In preparation for using this tracer in humans, we have performed whole-body PET studies in mice to evaluate the biodistribution and dosimetry of [ 18 F]Mefway. Methods Six mice (three females and three ma...