Delta-Catenin as a Modulator of Rho GTPases in Neurons

• Published in: Frontiers in cellular neuroscience Vol. 16; p. 939143
• Main Authors: Donta, Maxsam S., Srivastava, Yogesh, McCrea, Pierre D.
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Research Foundation 04.07.2022; Frontiers Media S.A
• Subjects: Actin; Adherens junctions; Alzheimer's disease; Amino acids; Autism; Cadherins; Catenin; Cdc42; Cdc42 protein; Cell division; Central nervous system; Cytoskeleton; delta-catenin; Dendritic spines; Guanosine triphosphatases; Insects; Morphology; N-Cadherin; Neurodegenerative diseases; Neurons; Neuroscience; Proteins; Rac1; Rac1 protein; Rho GTPase; RhoA; Roles; Synaptogenesis; delta-catenin; catenin; Rac1; GTPase; Rho GTPase; neurons; RhoA; Cdc42

Small Rho GTPases are molecular switches that are involved in multiple processes including regulation of the actin cytoskeleton. These GTPases are activated (turned on) and inactivated (turned off) through various upstream effector molecules to carry out many cellular functions. One such upstream mo...