An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation

• Published in: Molecules (Basel, Switzerland) Vol. 25; no. 22; p. 5474
• Main Authors: Saha, Sarmistha, Buttari, Brigitta, Panieri, Emiliano, Profumo, Elisabetta, Saso, Luciano
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.11.2020; MDPI
• Subjects: Adaptive immunity; Amino acids; Animals; Antigens; Biomarkers; Cytokines; Deoxyribonucleic acid; Disease Susceptibility; DNA; Gene Expression Regulation; Homeostasis; Humans; Inflammation; Inflammation - etiology; Inflammation - metabolism; Inflammation - pathology; Kelch-Like ECH-Associated Protein 1 - chemistry; Kelch-Like ECH-Associated Protein 1 - genetics; Kelch-Like ECH-Associated Protein 1 - metabolism; Kinases; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism; NF-kappa B - metabolism; Oxidation-Reduction; Oxidative Stress; Pathogens; Physiology; Protein Binding; Proteins; Review; Signal Transduction; Structure-Activity Relationship; Transcription factors; Tumor necrosis factor-TNF; Keap1; polyphenols; Nrf2; inflammation; oxidative stress

Inflammation is a key driver in many pathological conditions such as allergy, cancer, Alzheimer’s disease, and many others, and the current state of available drugs prompted researchers to explore new therapeutic targets. In this context, accumulating evidence indicates that the transcription factor...