Clemastine improves hypomyelination in rats with hypoxic-ischemic brain injury by reducing microglia-derived IL-1β via P38 signaling pathway

• Published in: Journal of neuroinflammation Vol. 17; no. 1; p. 57
• Main Authors: Xie, Di, Ge, Xiaoli, Ma, Yanli, Tang, Jialong, Wang, Yang, Zhu, Yajie, Gao, Chengjin, Pan, Shuming
• Format: Journal Article
• Language: English
• Published: England BioMed Central 15.02.2020; BMC
• Subjects: Brain injury; Brain research; Carotid artery; Cell culture; Cerebral blood flow; Clemastine; Corpus callosum; Cytokines; Extracellular signal-regulated kinase; Glial stem cells; Histamine H1 receptors; Hypomyelination; Hypoxia; IL-1β; Inflammation; Interleukin-1β; Ischemia; Kinases; Laboratory animals; Microglia; Neuroprotection; Oligodendrocyte; Progenitor cells; Proteins; Signal transduction; Therapeutic applications; Traumatic brain injury; United States > US; Clemastine; Hypomyelination; Oligodendrocyte; Interleukin-1β; Microglia

Microglia activation is associated with the development of hypoxic-ischemic brain injury (HIBI). Neuroinflammation suppression might be a suitable therapeutic target in hypoxic oligodendrocyte injury. This study aims to determine whether clemastine can improve hypomyelination by suppressing the acti...