Cardiorenal Protective Effect of Costunolide against Doxorubicin-Induced Toxicity in Rats by Modulating Oxidative Stress, Inflammation and Apoptosis

• Published in: Molecules (Basel, Switzerland) Vol. 27; no. 7; p. 2122
• Main Authors: Xing, Wen, Wen, Chaoling, Wang, Deguo, Shao, Hui, Liu, Chunhong, He, Chunling, Olatunji, Opeyemi Joshua
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 25.03.2022; MDPI
• Subjects: Animals; antioxidant; Antioxidants; Antioxidants - metabolism; Apoptosis; Biomarkers; Biomarkers - metabolism; Cancer; cardiorenal protection; Cardiotoxicity; Cardiotoxicity - drug therapy; costunolide; Cytokines; doxorubicin; Doxorubicin - pharmacology; Humans; Inflammation - metabolism; Kinases; Lipids; Lipids - pharmacology; Oxidative Stress; Rats; Sesquiterpenes; Toxicity; Uric acid; antioxidant; cardiorenal protection; costunolide; doxorubicin; oxidative stress

Doxorubicin (DXB) is one of the most commonly used anticancer agents for treating solid and hematological malignancies; however, DXB-induced cardiorenal toxicity presents a limiting factor to its clinical usefulness in cancer patients. Costunolide (COST) is a naturally occurring sesquiterpene lacton...