Longitudinal Reproducibility of Neurite Orientation Dispersion and Density Imaging (NODDI) Derived Metrics in the White Matter

• Published in: Neuroscience Vol. 457; pp. 165 - 185
• Main Authors: Lehmann, Nico, Aye, Norman, Kaufmann, Jörn, Heinze, Hans-Jochen, Düzel, Emrah, Ziegler, Gabriel, Taubert, Marco
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.03.2021
• Subjects: Benchmarking; Brain - diagnostic imaging; Cross-Sectional Studies; Diffusion Magnetic Resonance Imaging; Diffusion Tensor Imaging; diffusion-weighted imaging; Humans; Neurite Orientation Dispersion and Density Imaging (NODDI); Neurites; Precision; Reliability; Reproducibility; Reproducibility of Results; White Matter - diagnostic imaging; MRI; CVWS; SD; NDI; BBR; DW; ODI; SNR; WM; CSF; DWI; MD; NODDI; CVBS; FSL; BMI; ISO; CI; GM; ICC; TBSS; Neurite Orientation Dispersion and Density Imaging (NODDI); ROI; CV; diffusion-weighted imaging; Reproducibility; Precision; FWHM; RM-ANOVA; FA; T1w; Reliability; EPI

•We analyzed absolute (CV) and relative (ICC) reproducibility of NODDI metrics.•Reproducibility of ROI-based, "VBM-style" and TBSS analysis was compared.•Reproducibility of NODDI metrics was generally high.•Reproducibility of NODDI metrics depends on SNR and choice of analysis approach.•Im...