Effect of anti-immunoglobulin E on nasal inflammation in patients with seasonal allergic rhinoconjunctivitis

• Published in: Clinical and experimental allergy Vol. 34; no. 7; pp. 1079 - 1085
• Main Authors: Bez, C., Schubert, R., Kopp, M., Ersfeld, Y., Rosewich, M., Kuehr, J., Kamin, W., Berg, A. V., Wahu, U., Zielen, S.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Ltd 01.07.2004; Blackwell; Wiley Subscription Services, Inc
• Subjects: Adolescent; Allergic diseases; anti-IgE; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal - therapeutic use; Antibodies, Monoclonal, Humanized; Betula; Biological and medical sciences; Blood Proteins - analysis; Body Fluids - chemistry; Child; Desensitization, Immunologic - methods; Double-Blind Method; ECP; Eosinophil Granule Proteins; Female; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Humans; IL-6; IL-8; Immunoglobulin E - immunology; Immunopathology; Interleukin-6 - analysis; Interleukin-8 - analysis; Male; Medical sciences; nasal inflammation; Nasal Mucosa - immunology; Nasal Mucosa - secretion; Omalizumab; Poaceae; Pollen; Rhinitis, Allergic, Seasonal - immunology; Rhinitis, Allergic, Seasonal - therapy; Ribonucleases - analysis; seasonal allergic rhinitis; Serine Endopeptidases - analysis; specific immunotherapy; tryptase; Tryptases; Allergy; Nose disease; Rhinitis; IgE; Conjunctiva disease; Conjunctivitis; Interleukin 6; anti-IgE; seasonal allergic rhinitis; Immunology; Immunotherapy; ENT disease; specific immunotherapy; Interleukin 8; Human; Immunopathology; EC 3.4.21.59; Immunoglobulins; Serine endopeptidases; Enzyme; nasal inflammation; Cytokine; Inflammation; IL-8; IL-6; Peptidases; Eye disease; Treatment; ECP; Tryptase; Hydrolases

Summary Background Binding of allergens to IgE on mast cells and basophils causes release of inflammatory mediators in nasal secretions. Objective The combined effect of specific immunotherapy (SIT) and omalizumab, a humanized monoclonal anti‐IgE antibody, on release of eosinophilic cationic protein...