Long-term results of Phase II study of high dose photon/proton radiotherapy in the management of spine chordomas, chondrosarcomas, and other sarcomas

• Published in: Journal of surgical oncology Vol. 110; no. 2; pp. 115 - 122
• Main Authors: DeLaney, Thomas F., Liebsch, Norbert J., Pedlow, Frank X., Adams, Judith, Weyman, Elizabeth A., Yeap, Beow Y., Depauw, Nicolas, Nielsen, G. Petur, Harmon, David C., Yoon, Sam S., Chen, Yen-Lin, Schwab, Joseph H., Hornicek, Francis J.
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.08.2014; Wiley Subscription Services, Inc
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Chondrosarcoma - mortality; Chondrosarcoma - radiotherapy; Chondrosarcoma - surgery; chordoma; Chordoma - mortality; Chordoma - radiotherapy; Chordoma - surgery; Follow-Up Studies; Humans; Kaplan-Meier Estimate; Lumbar Vertebrae - surgery; Medical research; Middle Aged; Photons - adverse effects; Photons - therapeutic use; Prospective Studies; proton radiotherapy; Proton Therapy - adverse effects; Radiation therapy; Radiotherapy, Adjuvant - adverse effects; Radiotherapy, Conformal - methods; Sacrum - surgery; sarcoma; Sarcoma - mortality; Sarcoma - radiotherapy; Sarcoma - surgery; Spinal Neoplasms - radiotherapy; Spinal Neoplasms - surgery; spine; Spine - surgery; Survival Rate; Thoracic Vertebrae - surgery; Treatment Outcome; Tumors; Young Adult; proton radiotherapy; spine; sarcoma; chordoma

Background Negative surgical margins are uncommon for spine sarcomas; hence, adjuvant radiotherapy (RT) may be recommended but tumor dose may be constrained by spinal cord, nerve, and viscera tolerance. Methods Prospective Phase II clinical trial incorporating high dose RT. Eligible patients had pri...