Radical aryl migration enables diversity-oriented synthesis of structurally diverse medium/macro- or bridged-rings

• Published in: Nature communications Vol. 7; no. 1; p. 13852
• Main Authors: Li, Lei, Li, Zhong-Liang, Wang, Fu-Li, Guo, Zhen, Cheng, Yong-Feng, Wang, Na, Dong, Xiao-Wu, Fang, Chao, Liu, Jingjiang, Hou, Chunhui, Tan, Bin, Liu, Xin-Yuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 22.12.2016; Nature Publishing Group; Nature Portfolio
• Subjects: 639/638/403/933; 639/638/403/935; 639/638/549/2132; Alcohol; Alkenes; Alkenes - chemistry; Bridged-Ring Compounds - chemical synthesis; Bridged-Ring Compounds - chemistry; Bridged-Ring Compounds - pharmacology; Cell Line, Tumor; Cell Survival - drug effects; Chemistry Techniques, Synthetic - methods; HEK293 Cells; Humanities and Social Sciences; Humans; Ketones - chemical synthesis; Ketones - chemistry; Ketones - pharmacology; Libraries; Macrocyclic Compounds - chemical synthesis; Macrocyclic Compounds - chemistry; Macrocyclic Compounds - pharmacology; Models, Chemical; Molecular Structure; multidisciplinary; Science; Science (multidisciplinary); Thermodynamics; China

Medium-sized and medium-bridged rings are attractive structural motifs in natural products and therapeutic agents. Due to the unfavourable entropic and/or enthalpic factors with these ring systems, their efficient construction remains a formidable challenge. To address this problem, we herein disclo...