Inhibitory Effects of Sialic Acid- or N-Acetylglucosamine-Specific Lectins on Histamine Release Induced by Compound 48/80, Bradykinin and a Polyethylenimine in Rat Peritoneal Mast Cells

• Published in: Japanese Journal of Pharmacology Vol. 64; no. 1; pp. 1 - 8
• Main Authors: Matsuda, Koji, Niitsuma, Akinao, Uchida, Masaatsu K., Suzuki-Nishimura, Tamiko
• Format: Journal Article
• Language: English; Japanese
• Published: Japan The Japanese Pharmacological Society 1994
• Subjects: Acetylglucosamine - metabolism; Agglutinins - pharmacology; Animals; Bradykinin - pharmacology; Electrophoresis, Polyacrylamide Gel; Glycoproteins - analysis; Histamine Antagonists - pharmacology; Histamine release; Histamine Release - drug effects; In Vitro Techniques; Lectin; Lectins - pharmacology; Mast cell; Mast Cells - chemistry; Mast Cells - drug effects; Mast Cells - metabolism; Mitogens - pharmacology; N-Acetylneuraminic Acid; Neuraminidase - pharmacology; Non-immunologic stimuli; Oligosaccharides; p-Methoxy-N-methylphenethylamine - pharmacology; Peritoneal Cavity - cytology; Polyethyleneimine - pharmacology; Rats; Sialic Acids - metabolism; Sugar-specificity; Lectin; Mast cell; Sugar-specificity; Histamine release; Non-immunologic stimuli

The effects of seven lectins with various sugar-specificities on histamine release from rat peritoneal mast cells induced by non-immunologic stimuli were studied. The non-immunologic stimuli used were three basic secretagogues, compound 48/80, bradykinin and PEI6 (polyethylenimine with a molecular w...