Mechanisms of action of ionic liquids on living cells: the state of the art

Ionic liquids (ILs) are a relatively new class of organic electrolytes composed of an organic cation and either an organic or inorganic anion, whose melting temperature falls around room-temperature. In the last 20 years, the toxicity of ILs towards cells and micro-organisms has been heavily investi...

Full description

Saved in:
Bibliographic Details
Published inBiophysical reviews Vol. 12; no. 5; pp. 1187 - 1215
Main Authors Kumari, Pallavi, Pillai, Visakh V.S., Benedetto, Antonio
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2020
Springer Nature B.V
Subjects
Biochemistry
Biological and Medical Physics
Biological Techniques
Biomedical and Life Sciences
Biomolecules
Biophysics
Cell Biology
Cell membranes
Chloroplasts
DNA fragmentation
Electrolytic cells
Ionic liquids
Life Sciences
Lipids
Melt temperature
Membrane Biology
Mitochondria
Nanotechnology
Nonaqueous electrolytes
Nuclear membranes
Reactive oxygen species
Review
Reviews
Room temperature
State-of-the-art reviews
Toxicity
Viscoelasticity
Nuclear membrane disruption
Reactive oxygen species
Mitochondrial dysfunction
DNA damage
Transmembrane protein function
System biology
Mitochondrial permeabilization
Signaling pathways
Ionic liquids
Cell membrane disruption
Chloroplast damage
Mechanism of action
Cell membrane viscoelasticity
Online AccessGet full text
ISSN1867-2450
1867-2469
DOI10.1007/s12551-020-00754-w

Cover

Abstract Ionic liquids (ILs) are a relatively new class of organic electrolytes composed of an organic cation and either an organic or inorganic anion, whose melting temperature falls around room-temperature. In the last 20 years, the toxicity of ILs towards cells and micro-organisms has been heavily investigated with the main aim to assess the risks associated with their potential use in (industrial) applications, and to develop strategies to design greener ILs. Toxicity, however, is synonym with affinity, and this has stimulated, in turn, a series of biophysical and chemical-physical investigations as well as few biochemical studies focused on the mechanisms of action (MoAs) of ILs, key step in the development of applications in bio-nanomedicine and bio-nanotechnology. This review has the intent to present an overview of the state of the art of the MoAs of ILs, which have been the focus of a limited number of studies but still sufficient enough to provide a first glimpse on the subject. The overall picture that emerges is quite intriguing and shows that ILs interact with cells in a variety of different mechanisms, including alteration of lipid distribution and cell membrane viscoelasticity, disruption of cell and nuclear membranes, mitochondrial permeabilization and dysfunction, generation of reactive oxygen species, chloroplast damage (in plants), alteration of transmembrane and cytoplasmatic proteins/enzyme functions, alteration of signaling pathways, and DNA fragmentation. Together with our earlier review work on the biophysics and chemical-physics of IL-cell membrane interactions (Biophys. Rev. 9:309, 2017), we hope that the present review, focused instead on the biochemical aspects, will stimulate a series of new investigations and discoveries in the still new and interdisciplinary field of “ILs, biomolecules, and cells.”
AbstractList Ionic liquids (ILs) are a relatively new class of organic electrolytes composed of an organic cation and either an organic or inorganic anion, whose melting temperature falls around room-temperature. In the last 20 years, the toxicity of ILs towards cells and micro-organisms has been heavily investigated with the main aim to assess the risks associated with their potential use in (industrial) applications, and to develop strategies to design greener ILs. Toxicity, however, is synonym with affinity, and this has stimulated, in turn, a series of biophysical and chemical-physical investigations as well as few biochemical studies focused on the mechanisms of action (MoAs) of ILs, key step in the development of applications in bio-nanomedicine and bio-nanotechnology. This review has the intent to present an overview of the state of the art of the MoAs of ILs, which have been the focus of a limited number of studies but still sufficient enough to provide a first glimpse on the subject. The overall picture that emerges is quite intriguing and shows that ILs interact with cells in a variety of different mechanisms, including alteration of lipid distribution and cell membrane viscoelasticity, disruption of cell and nuclear membranes, mitochondrial permeabilization and dysfunction, generation of reactive oxygen species, chloroplast damage (in plants), alteration of transmembrane and cytoplasmatic proteins/enzyme functions, alteration of signaling pathways, and DNA fragmentation. Together with our earlier review work on the biophysics and chemical-physics of IL-cell membrane interactions (Biophys. Rev. 9:309, 2017), we hope that the present review, focused instead on the biochemical aspects, will stimulate a series of new investigations and discoveries in the still new and interdisciplinary field of “ILs, biomolecules, and cells.”
Ionic liquids (ILs) are a relatively new class of organic electrolytes composed of an organic cation and either an organic or inorganic anion, whose melting temperature falls around room-temperature. In the last 20 years, the toxicity of ILs towards cells and micro-organisms has been heavily investigated with the main aim to assess the risks associated with their potential use in (industrial) applications, and to develop strategies to design greener ILs. Toxicity, however, is synonym with affinity, and this has stimulated, in turn, a series of biophysical and chemical-physical investigations as well as few biochemical studies focused on the mechanisms of action (MoAs) of ILs, key step in the development of applications in bio-nanomedicine and bio-nanotechnology. This review has the intent to present an overview of the state of the art of the MoAs of ILs, which have been the focus of a limited number of studies but still sufficient enough to provide a first glimpse on the subject. The overall picture that emerges is quite intriguing and shows that ILs interact with cells in a variety of different mechanisms, including alteration of lipid distribution and cell membrane viscoelasticity, disruption of cell and nuclear membranes, mitochondrial permeabilization and dysfunction, generation of reactive oxygen species, chloroplast damage (in plants), alteration of transmembrane and cytoplasmatic proteins/enzyme functions, alteration of signaling pathways, and DNA fragmentation. Together with our earlier review work on the biophysics and chemical-physics of IL-cell membrane interactions (Biophys. Rev. 9:309, 2017), we hope that the present review, focused instead on the biochemical aspects, will stimulate a series of new investigations and discoveries in the still new and interdisciplinary field of “ILs, biomolecules, and cells.”
Ionic liquids (ILs) are a relatively new class of organic electrolytes composed of an organic cation and either an organic or inorganic anion, whose melting temperature falls around room-temperature. In the last 20 years, the toxicity of ILs towards cells and micro-organisms has been heavily investigated with the main aim to assess the risks associated with their potential use in (industrial) applications, and to develop strategies to design greener ILs. Toxicity, however, is synonym with affinity, and this has stimulated, in turn, a series of biophysical and chemical-physical investigations as well as few biochemical studies focused on the mechanisms of action (MoAs) of ILs, key step in the development of applications in bio-nanomedicine and bio-nanotechnology. This review has the intent to present an overview of the state of the art of the MoAs of ILs, which have been the focus of a limited number of studies but still sufficient enough to provide a first glimpse on the subject. The overall picture that emerges is quite intriguing and shows that ILs interact with cells in a variety of different mechanisms, including alteration of lipid distribution and cell membrane viscoelasticity, disruption of cell and nuclear membranes, mitochondrial permeabilization and dysfunction, generation of reactive oxygen species, chloroplast damage (in plants), alteration of transmembrane and cytoplasmatic proteins/enzyme functions, alteration of signaling pathways, and DNA fragmentation. Together with our earlier review work on the biophysics and chemical-physics of IL-cell membrane interactions (Biophys. Rev. 9:309, 2017), we hope that the present review, focused instead on the biochemical aspects, will stimulate a series of new investigations and discoveries in the still new and interdisciplinary field of "ILs, biomolecules, and cells."Ionic liquids (ILs) are a relatively new class of organic electrolytes composed of an organic cation and either an organic or inorganic anion, whose melting temperature falls around room-temperature. In the last 20 years, the toxicity of ILs towards cells and micro-organisms has been heavily investigated with the main aim to assess the risks associated with their potential use in (industrial) applications, and to develop strategies to design greener ILs. Toxicity, however, is synonym with affinity, and this has stimulated, in turn, a series of biophysical and chemical-physical investigations as well as few biochemical studies focused on the mechanisms of action (MoAs) of ILs, key step in the development of applications in bio-nanomedicine and bio-nanotechnology. This review has the intent to present an overview of the state of the art of the MoAs of ILs, which have been the focus of a limited number of studies but still sufficient enough to provide a first glimpse on the subject. The overall picture that emerges is quite intriguing and shows that ILs interact with cells in a variety of different mechanisms, including alteration of lipid distribution and cell membrane viscoelasticity, disruption of cell and nuclear membranes, mitochondrial permeabilization and dysfunction, generation of reactive oxygen species, chloroplast damage (in plants), alteration of transmembrane and cytoplasmatic proteins/enzyme functions, alteration of signaling pathways, and DNA fragmentation. Together with our earlier review work on the biophysics and chemical-physics of IL-cell membrane interactions (Biophys. Rev. 9:309, 2017), we hope that the present review, focused instead on the biochemical aspects, will stimulate a series of new investigations and discoveries in the still new and interdisciplinary field of "ILs, biomolecules, and cells."
Author Kumari, Pallavi
Benedetto, Antonio
Pillai, Visakh V.S.
Author_xml – sequence: 1
  givenname: Pallavi
  surname: Kumari
  fullname: Kumari, Pallavi
  organization: Department of Sciences, University of Roma Tre, School of Physics, University College Dublin, Conway Institute of Biomolecular and Biomedical Research, University College Dublin
– sequence: 2
  givenname: Visakh V.S.
  surname: Pillai
  fullname: Pillai, Visakh V.S.
  organization: Department of Sciences, University of Roma Tre, School of Physics, University College Dublin, Conway Institute of Biomolecular and Biomedical Research, University College Dublin
– sequence: 3
  givenname: Antonio
  orcidid: 0000-0002-9324-8595
  surname: Benedetto
  fullname: Benedetto, Antonio
  email: antonio.benedetto@uniroma3.it, antonio.benedetto@ucd.ie, antonio.benedetto@psi.ch
  organization: Department of Sciences, University of Roma Tre, School of Physics, University College Dublin, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Laboratory for Neutron Scattering, Paul Scherrer Institute
BackLink https://www.ncbi.nlm.nih.gov/pubmed/32936423$$D View this record in MEDLINE/PubMed
BookMark eNp9UctO3TAQtRCoPMoPsKgisWGT1m87XSAh1FJUUDft2nIc516jXBvshKv-fSdcHoUFqzmjOWfmzMw-2o4peoSOCP5MMFZfCqFCkBpTXEMqeL3eQntES1VTLpvtZyzwLtov5QZjyakWH9Auow0DzPbQz2vvljaGsipV6ivrxpDijCAEVw3hbgodlCLA-xAXlfPDUL5W49JXZbSjn7lzYvP4Ee30dij-8DEeoD_fv_0-_1Ff_bq4PD-7qh1v6LrWDlutXCe1p1o1LaSyYb2QGraQjLWyASR7xtteW01ow13HW6c71_lOKnaATjd9b6d25Tvn45jtYG5zWNn81yQbzOtKDEuzSPdGCQVTGDQ4eWyQ093ky2hWocyL2ejTVAzlnAmiYDBQj99Qb9KUI6wHLMU0kULNrE__O3q28nRnIOgNweVUSva9cQGuB0cGg2EwBJv5pWbzUgMvNQ8vNWuQ0jfSp-7vithGVIAcFz6_2H5H9Q9Ba7Nr
CitedBy_id crossref_primary_10_1007_s11172_024_4362_z
crossref_primary_10_3390_pharmaceutics13010018
crossref_primary_10_1021_acs_jpcb_2c02212
crossref_primary_10_1016_j_molliq_2021_117077
crossref_primary_10_1007_s10811_025_03477_1
crossref_primary_10_1016_j_molliq_2023_122823
crossref_primary_10_1021_acs_chemrev_3c00420
crossref_primary_10_3390_microorganisms9040730
crossref_primary_10_1021_envhealth_4c00088
crossref_primary_10_2174_0113862073285654240308055228
crossref_primary_10_1016_j_ecoenv_2022_114334
crossref_primary_10_1016_j_indcrop_2022_115476
crossref_primary_10_3390_plants12040914
crossref_primary_10_1016_j_jcis_2023_11_158
crossref_primary_10_1016_j_desal_2023_117120
crossref_primary_10_1039_D1OB00011J
crossref_primary_10_1016_j_molliq_2022_118673
crossref_primary_10_1021_acs_jpcb_1c00592
crossref_primary_10_1007_s12551_020_00755_9
crossref_primary_10_1038_s41597_024_04190_3
crossref_primary_10_1016_j_biotechadv_2021_107702
crossref_primary_10_1002_adma_202406080
crossref_primary_10_1016_j_molliq_2023_121322
crossref_primary_10_1007_s11095_022_03322_x
crossref_primary_10_1016_j_molliq_2025_127277
crossref_primary_10_1002_adfm_202306644
crossref_primary_10_1016_j_scp_2020_100369
crossref_primary_10_1016_j_drudis_2021_01_031
crossref_primary_10_1039_D4GC00528G
crossref_primary_10_3390_sci7010002
crossref_primary_10_3390_molecules29071524
crossref_primary_10_1039_D3CS00510K
crossref_primary_10_1007_s12551_023_01173_3
crossref_primary_10_1016_j_envint_2024_109089
crossref_primary_10_1016_j_toxlet_2023_07_011
crossref_primary_10_3390_pharmaceutics16050642
crossref_primary_10_59324_ejtas_2024_2_5__37
crossref_primary_10_1039_D1CS00946J
crossref_primary_10_1007_s00203_024_04035_y
crossref_primary_10_1021_acs_langmuir_3c00883
crossref_primary_10_1021_acs_jpclett_2c01873
crossref_primary_10_1021_acs_jmedchem_4c01780
crossref_primary_10_1002_adtp_202200332
crossref_primary_10_1016_j_microc_2021_106667
crossref_primary_10_1016_j_jhazmat_2025_138011
crossref_primary_10_1002_smll_202206968
crossref_primary_10_1016_j_molliq_2022_120750
crossref_primary_10_3390_molecules29102326
crossref_primary_10_1016_j_chroma_2021_462219
crossref_primary_10_3390_ma14216231
crossref_primary_10_1021_acs_jpclett_2c01505
crossref_primary_10_1080_07391102_2024_2329307
crossref_primary_10_1002_adfm_202104148
crossref_primary_10_1016_j_ejpb_2022_11_018
crossref_primary_10_1016_j_molliq_2024_125698
crossref_primary_10_1016_j_molstruc_2022_133947
crossref_primary_10_1021_acs_jpcb_1c09476
crossref_primary_10_3390_molecules28031107
crossref_primary_10_1016_j_mtcomm_2021_102672
crossref_primary_10_1093_femsyr_foac036
crossref_primary_10_1088_2516_1075_abfd21
crossref_primary_10_1021_acs_jpcb_1c01347
crossref_primary_10_1021_acs_jpcb_3c06797
crossref_primary_10_1080_10837450_2024_2417004
crossref_primary_10_1016_j_molliq_2022_120450
crossref_primary_10_1002_bit_28198
crossref_primary_10_3390_pharmaceutics16040496
crossref_primary_10_1016_j_jhazmat_2021_125215
crossref_primary_10_1016_j_chemosphere_2024_142964
crossref_primary_10_1080_10610278_2021_1975280
crossref_primary_10_1016_j_chemosphere_2024_143252
crossref_primary_10_1039_D4CP01236D
crossref_primary_10_3390_polym15204097
crossref_primary_10_1021_acssuschemeng_0c08790
crossref_primary_10_1007_s12551_021_00782_0
crossref_primary_10_3390_cancers15030756
crossref_primary_10_1007_s00253_024_13353_6
crossref_primary_10_1007_s12551_020_00764_8
crossref_primary_10_1080_08927022_2022_2113810
crossref_primary_10_1016_j_molliq_2024_124420
crossref_primary_10_1039_D1GC01520F
crossref_primary_10_3390_pharmaceutics16010151
crossref_primary_10_1016_j_microb_2024_100111
crossref_primary_10_1134_S1070363223170036
crossref_primary_10_3390_ijerph19148719
crossref_primary_10_3390_ijms221910487
crossref_primary_10_1016_j_molliq_2024_125631
crossref_primary_10_1016_j_molliq_2024_125483
crossref_primary_10_1016_j_cis_2023_102848
crossref_primary_10_1002_ardp_202200085
crossref_primary_10_1016_j_molliq_2022_119989
crossref_primary_10_1016_j_ceja_2024_100670
crossref_primary_10_1007_s11224_023_02259_0
crossref_primary_10_3390_molecules27061974
crossref_primary_10_1016_j_jmb_2024_168627
crossref_primary_10_1021_acs_jpcb_4c01455
crossref_primary_10_1007_s11356_023_25562_z
crossref_primary_10_1021_acs_est_4c12617
crossref_primary_10_3390_molecules27238492
crossref_primary_10_1021_acs_jpcb_2c00710
Cites_doi 10.1007/s12551-018-0425-4
10.1039/C1NJ20470J
10.1038/s41573-019-0058-8
10.1371/journal.pone.0229745
10.1016/j.jhazmat.2018.01.028
10.1007/s12551-018-0426-3
10.1021/jz201006b
10.1021/acs.langmuir.6b04359
10.1016/j.procbio.2014.09.014
10.1016/j.envpol.2019.04.043
10.1039/b615406a
10.1021/cr1003248
10.1038/nchembio.1986
10.1007/s00232001078
10.1016/j.ecoenv.2006.08.008
10.1021/acs.jpclett.0c02149
10.1038/nrmicro2333
10.1073/pnas.1521988112
10.1039/b921805j
10.1016/j.ecoenv.2007.11.002
10.1021/acsbiomaterials.8b00486
10.1021/acs.langmuir.7b04361
10.1016/j.physb.2018.02.043
10.1016/j.ecoenv.2009.10.004
10.1038/s43246-020-0035-0
10.1007/s12551-018-0424-5
10.1073/pnas.1005485107
10.1002/tox.20443
10.1007/s12551-017-0279-1
10.3390/ijms19030790
10.1038/nrmicro1098
10.1073/pnas.0702439104
10.1021/jp7116592
10.1016/j.jhazmat.2014.11.028
10.1002/chem.201704924
10.1016/j.bbrc.2015.10.015
10.1016/j.tiv.2017.09.025
10.1016/j.chemosphere.2015.11.055
10.1039/C7SM01799E
10.1016/j.ecoenv.2020.110392
10.1016/j.molstruc.2007.09.022
10.1021/jp507631h
10.1007/s12551-017-0388-x
10.1016/j.molliq.2017.02.078
10.1007/s11356-015-4794-y
10.1016/j.ecoenv.2008.02.022
10.1039/C7RA01520H
10.1038/srep19889
10.1039/b419172b
10.1016/j.jhazmat.2016.08.056
10.1073/pnas.1722338115
10.1039/b704503d
10.1039/B511554J
10.1080/02772240600589505
10.1007/s00216-008-2523-9
10.1016/S0147-6513(03)00105-2
10.1021/tx200228c
10.1016/j.jconrel.2020.04.038
10.1038/s41467-017-02118-7
10.1016/j.tiv.2012.07.006
10.1007/s12551-018-0419-2
10.1016/j.jhazmat.2015.12.028
10.1039/C0MD00201A
10.1263/jbb.105.425
10.1038/s41467-020-15257-1
10.1002/cssc.201700261
10.1016/j.chemosphere.2013.08.092
10.1016/j.ecoenv.2015.07.010
10.1016/j.scitotenv.2017.10.021
10.1002/adtp.202000041
10.1016/j.tiv.2018.05.013
10.1073/pnas.1517541113
10.1016/j.ecoenv.2007.08.011
10.1007/s12551-018-0422-7
10.1002/cssc.201300459
10.1039/b807019a
10.1016/j.ijbiomac.2016.12.005
10.1016/j.bbamem.2019.183103
10.1016/j.aquatox.2015.10.024
10.1016/j.molliq.2018.06.045
10.1016/j.jhazmat.2013.11.003
10.1016/j.chemosphere.2016.09.140
10.1016/j.chemphyslip.2016.11.003
10.1038/s41467-019-11503-3
10.1021/jp412281n
10.1007/s10646-011-0785-z
10.1039/C4TX00079J
10.1039/c0gc00813c
10.1039/C004968A
10.1038/srep18444
10.1039/b807214k
10.1073/pnas.1319900111
10.1021/acsomega.8b03691
10.1039/b817717c
10.1016/j.jconrel.2018.07.029
10.1016/j.molliq.2019.111751
10.1016/j.ecoenv.2010.01.017
10.3390/ijms20122865
10.1021/acs.langmuir.8b01554
10.1021/acs.langmuir.6b02496
10.1039/D0CP00801J
10.1016/j.jconrel.2020.03.018
10.1021/acs.langmuir.6b03192
10.1038/sj.bjp.0705374
10.1016/j.jconrel.2019.08.029
10.1016/j.chemosphere.2019.124919
10.1002/adma.201901103
10.1897/04-614R.1
10.1007/s12551-017-0390-3
10.1021/acs.chemrev.6b00562
10.1007/s12551-018-0421-8
10.1016/j.chemosphere.2009.11.047
10.1002/open.201100003
10.1016/j.chemosphere.2016.02.029
10.3109/15569543.2013.867885
10.1002/biot.201900073
10.1038/nrmicro3380
10.1146/annurev-chembioeng-060713-040024
10.1063/1.4915918
10.1021/acssuschemeng.5b01385
10.1039/b706677p
10.1016/j.yrtph.2010.03.006
10.1016/j.watres.2017.08.046
10.1007/s12551-018-0410-y
10.1038/s42004-020-0302-5
10.1016/j.molliq.2020.112547
10.1016/j.chemosphere.2019.124436
10.1039/b821842k
10.1016/j.ecoenv.2020.110902
10.1016/j.bmcl.2009.06.086
10.1016/j.bmcl.2009.11.085
10.1039/C1FD00071C
10.1515/aiht-2017-68-2979
10.1097/ICO.0b013e31823f0a86
10.1073/pnas.1914426116
10.1038/srep11935
10.1038/s41586-019-1357-2
10.1002/btm2.10083
10.1039/b602161a
10.1016/j.chemosphere.2013.01.013
10.1073/pnas.1518034113
10.1016/j.chemosphere.2016.08.061
10.1021/acsomega.0c01098
10.1038/nature14098
10.1021/acs.langmuir.6b00768
10.1177/0960327110371259
10.1007/s10646-008-0272-3
10.1039/b907462g
10.1016/j.ecoenv.2013.03.002
10.1073/pnas.1814924116
10.1038/s41598-019-56731-1
10.3390/biom9060251
10.1039/C4SM01528B
10.1016/j.ijpharm.2019.05.020
10.1016/j.jmb.2018.05.002
10.1016/j.ejmech.2019.111832
10.1016/j.ecoenv.2013.12.022
10.1039/C3CC48650H
10.1016/j.fct.2019.111069
10.1016/j.ecoenv.2012.06.013
10.1073/pnas.1403995111
10.1016/j.ecoenv.2015.06.018
10.1016/j.chemosphere.2009.07.026
10.1007/s11356-013-2348-8
10.1016/j.envpol.2013.06.007
10.1002/slct.201903435
10.1021/cr980032t
10.1039/C6CP05601F
10.1351/pac200072071391
10.1007/s00249-011-0760-x
10.1073/pnas.1909585117
10.1016/j.ecoenv.2010.07.020
10.1073/pnas.1611173113
10.1039/C4MD00161C
10.1002/jbt.21495
10.1002/anie.201510090
10.1016/j.bbapap.2009.09.017
10.1016/j.ecoenv.2009.05.002
10.1021/acs.langmuir.6b03182
10.1073/pnas.1613055113
10.1016/j.bmcl.2008.08.090
10.1039/C9RA02521A
10.1021/acs.molpharmaceut.7b00442
10.1002/chem.202003466
10.1039/b316491h
10.1016/j.watres.2009.09.030
ContentType Journal Article
Copyright The Author(s) 2020
The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2020
– notice: The Author(s) 2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
NPM
7X8
5PM
DOI 10.1007/s12551-020-00754-w
DatabaseName Springer Nature OA Free Journals
CrossRef
PubMed
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
PubMed
MEDLINE - Academic
DatabaseTitleList
CrossRef

PubMed
MEDLINE - Academic
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 1867-2469
EndPage 1215
ExternalDocumentID PMC7575683
32936423
10_1007_s12551_020_00754_w
Genre Journal Article
Review
GrantInformation_xml – fundername: Science Foundation Ireland
  grantid: 15-SIRG-3538
– fundername: Ministero dell’Istruzione, dell’Università e della Ricerca
  grantid: MIUR-DM080518-372
  funderid: http://dx.doi.org/10.13039/501100003407
– fundername: Ministero dell'Istruzione, dell'Università e della Ricerca
  grantid: MIUR-DM080518-372
– fundername: ;
  grantid: 15-SIRG-3538
– fundername: ;
  grantid: MIUR-DM080518-372
GroupedDBID -5F
-5G
-BR
-EM
-~C
06C
06D
0R~
0VY
1N0
203
29~
2JY
2KG
2VQ
2~H
30V
4.4
406
408
409
40D
40E
67N
6NX
8TC
96X
AAAVM
AACDK
AAHNG
AAIAL
AAJBT
AAJKR
AANXM
AANZL
AARHV
AARTL
AASML
AATNV
AATVU
AAUYE
AAWCG
AAYIU
AAYQN
AAYTO
AAYZH
AAZMS
ABAKF
ABBXA
ABDZT
ABECU
ABFTV
ABHLI
ABHQN
ABJNI
ABJOX
ABKCH
ABMQK
ABPLI
ABQBU
ABSXP
ABTEG
ABTHY
ABTKH
ABTMW
ABULA
ABWNU
ABXPI
ACAOD
ACDTI
ACGFS
ACHSB
ACKNC
ACMDZ
ACMLO
ACOKC
ACOMO
ACPIV
ACPRK
ACZOJ
ADBBV
ADHHG
ADHIR
ADINQ
ADKNI
ADKPE
ADRFC
ADTPH
ADURQ
ADYFF
ADZKW
AEBTG
AEFQL
AEGNC
AEJHL
AEJRE
AEKMD
AEMSY
AEOHA
AEPYU
AESKC
AEVLU
AEXYK
AFBBN
AFLOW
AFQWF
AFWTZ
AFZKB
AGAYW
AGDGC
AGJBK
AGMZJ
AGQEE
AGQMX
AGRTI
AGWZB
AGYKE
AHAVH
AHBYD
AHSBF
AHYZX
AIAKS
AIGIU
AIIXL
AILAN
AITGF
AJBLW
AJRNO
AJZVZ
AKMHD
ALFXC
ALMA_UNASSIGNED_HOLDINGS
AMKLP
AMXSW
AMYLF
AMYQR
ANMIH
AOCGG
AOIJS
AUKKA
AXYYD
BA0
BGNMA
C6C
CAG
COF
CSCUP
DDRTE
DNIVK
DPUIP
EBLON
EBS
EIOEI
EJD
EN4
ESBYG
F5P
FERAY
FFXSO
FIGPU
FINBP
FNLPD
FRRFC
FSGXE
FYJPI
G-Y
G-Z
GGCAI
GGRSB
GJIRD
GQ6
GQ7
GQ8
GXS
H13
HF~
HG6
HLICF
HMJXF
HQYDN
HRMNR
HYE
HZ~
IJ-
IKXTQ
IWAJR
IXC
IXD
IZIGR
I~X
J-C
J0Z
JBSCW
JCJTX
JZLTJ
KOV
LLZTM
M4Y
N9A
NPVJJ
NQJWS
NU0
O9-
O93
O9I
O9J
OAM
OK1
PT4
QOR
QOS
R89
RLLFE
ROL
RPM
RSV
S1Z
S27
S3A
S3B
SDH
SHX
SISQX
SJYHP
SNE
SNPRN
SNX
SOHCF
SOJ
SPH
SPISZ
SRMVM
SSLCW
SSXJD
STPWE
T13
TSG
U2A
U9L
UG4
UOJIU
UTJUX
UZXMN
VC2
VFIZW
W48
WK8
Z45
Z7U
Z83
ZMTXR
ZOVNA
~A9
AAPKM
AAYXX
ABBRH
ABDBE
ABFSG
ACSTC
AEZWR
AFDZB
AFHIU
AFOHR
AHPBZ
AHWEU
AIXLP
ATHPR
AYFIA
CITATION
ABRTQ
NPM
7X8
5PM
ID FETCH-LOGICAL-c492w-8c0a87cd68e2879bc0a693f568007633b698006f34bf8a81294cd4bc8dcded673
IEDL.DBID U2A
ISSN 1867-2450
IngestDate Thu Aug 21 18:31:48 EDT 2025
Fri Jul 11 10:11:28 EDT 2025
Fri Jul 25 11:06:55 EDT 2025
Mon Jul 21 05:51:34 EDT 2025
Tue Jul 01 02:55:27 EDT 2025
Thu Apr 24 22:56:26 EDT 2025
Fri Feb 21 02:33:21 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 5
Keywords Nuclear membrane disruption
Reactive oxygen species
Mitochondrial dysfunction
DNA damage
Transmembrane protein function
System biology
Mitochondrial permeabilization
Signaling pathways
Ionic liquids
Cell membrane disruption
Chloroplast damage
Mechanism of action
Cell membrane viscoelasticity
Language English
License Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c492w-8c0a87cd68e2879bc0a693f568007633b698006f34bf8a81294cd4bc8dcded673
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
ObjectType-Review-3
content type line 23
ORCID 0000-0002-9324-8595
OpenAccessLink https://link.springer.com/10.1007/s12551-020-00754-w
PMID 32936423
PQID 2473816574
PQPubID 2043958
PageCount 29
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_7575683
proquest_miscellaneous_2443517294
proquest_journals_2473816574
pubmed_primary_32936423
crossref_citationtrail_10_1007_s12551_020_00754_w
crossref_primary_10_1007_s12551_020_00754_w
springer_journals_10_1007_s12551_020_00754_w
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 20201000
PublicationDateYYYYMMDD 2020-10-01
PublicationDate_xml – month: 10
  year: 2020
  text: 20201000
PublicationDecade 2020
PublicationPlace Berlin/Heidelberg
PublicationPlace_xml – name: Berlin/Heidelberg
– name: Germany
– name: Heidelberg
PublicationTitle Biophysical reviews
PublicationTitleAbbrev Biophys Rev
PublicationTitleAlternate Biophys Rev
PublicationYear 2020
Publisher Springer Berlin Heidelberg
Springer Nature B.V
Publisher_xml – name: Springer Berlin Heidelberg
– name: Springer Nature B.V
References Wu, Zeng, Wang (CR172) 2018; 348
Ranke, Mölter, Stock (CR127) 2004; 58
Kudłak, Owczarek, Namieśnik (CR66) 2015; 22
Nurunnabi, Ibsen, Tanner, Mitragotri (CR114) 2019; 116
Ibsen, Ma, Banerjee (CR58) 2018; 4
Kumar, Bisht, Venkatesu (CR69) 2017; 69
Liu, Zhu, Wang (CR84) 2015; 5
Brogden (CR25) 2005; 3
Sharma, Mukhopadhyay (CR139) 2018; 10
Blesic, Marques, Plechkova, Seddon, Rebelo, Lopes (CR23) 2007; 9
Kontro, Svedström, Duša, Ahvenainen, Ruokonen, Witos, Wiedmer (CR65) 2016; 201
Ryu, Lee, Iwata (CR134) 2015; 5
Chantereau, Sharma, Abednejad (CR29) 2020; 302
Liu, Zhang, Dong (CR87) 2015; 169
Yu, Li, Li (CR178) 2008; 71
Leitch, Abdelghany, Probert (CR74) 2020; 136
Maddali, Kumar, Marchand (CR97) 2011; 2
Young, Abdelghany, Leitch (CR177) 2020; 15
Kumar, Venkatesu (CR68) 2014; 49
Bui-Le, Clarke, Bröhl (CR27) 2020; 3
Ruokonen, Sanwald, Robciuc (CR133) 2018; 24
Earle, Seddon (CR41) 2000; 72
Tanner, Ibsen, Mitragotri (CR154) 2018; 286
Li, Ma, Jing, Wang (CR76) 2013; 93
Rotella, Kumari, Rodriguez (CR132) 2018; 10
Frade, Afonso (CR48) 2010; 29
Studzińska, Buszewski (CR150) 2009; 393
Grein, Müller, Scherer (CR51) 2020; 11
Hattori, Tagawa, Inai (CR53) 2019; 9
Liu, Zhu, Wang (CR90) 2016; 145
Tanner, Curreri, Balkaran (CR153) 2019; 31
Wenzel, Chiriac, Otto (CR168) 2014; 111
Marks, Kannan, Roncase (CR103) 2016; 113
Benedetto, Ballone (CR12) 2018; 551
Thamke, Tapase, Kodam (CR159) 2017; 125
Egorova, Gordeev, Ananikov (CR43) 2017; 117
Mwangi, Yin, Wang (CR112) 2019; 116
Jodynis-Liebert, Nowicki, Murias (CR61) 2010; 57
Rees, Seashore-Ludlow, Cheah (CR130) 2016; 12
Costa, Azevedo, Pinto, Saraiva (CR34) 2017; 10
Li, Zeng, Dong (CR82) 2012; 21
Kumari, Pillai, Rodriguez, Prencipe, Benedetto (CR73) 2020; 11
Dong, Zhu, Zhu (CR39) 2013; 91
Thamke, Chaudhari, Tapase (CR157) 2019; 250
Bachowska, Kazmierczak-Baranska, Cieslak (CR4) 2012; 1
Cvjetko Bubalo, Hanousek, Radošević (CR35) 2014; 101
Takekiyo, Yoshimura (CR152) 2018; 10
Williams, Sahbaz, Ford (CR169) 2014; 50
Li, Jing, Lei (CR78) 2012; 83
Liu, Zhu, Xie (CR86) 2014; 21
Luo, Wang, Yun (CR94) 2009; 77
Agatemor, Ibsen, Tanner, Mitragotri (CR1) 2018; 3
Xu, Wang, Du (CR173) 2020; 240
Ranke, Müller, Bottin-Weber (CR129) 2007; 67
Yoo, Shah, Zhu, Maginn (CR174) 2014; 10
Jing, Hu, Guo (CR59) 2014; 33
Bornemann, Herzog, Roling (CR24) 2020; 22
Wilson, Wang, Gitai, Seyedsayamdost (CR170) 2016; 113
Li, Luo, Yun (CR81) 2010; 78
Carson, Chau, Earle (CR28) 2009; 11
Docherty, Kulpa (CR38) 2005; 7
Zakrewsky, Lovejoy, Kern (CR182) 2014; 111
O’Toole, Wathier, Zegans, Shanks, Kowalski, Grinstaff (CR115) 2012; 31
Kumar, Trivedi, Reddy, Jha (CR70) 2011; 24
Stoimenovski, Dean, Izgorodina, MacFarlane (CR146) 2012; 154
Wan, Xia, Wang (CR161) 2018; 52
Petkovic, Hartmann, Adamová (CR120) 2012; 36
Thamke, Kodam (CR158) 2016; 320
Zhu, Varona, Anderson (CR185) 2020; 5
Yu, Mo, Zhang, Liu (CR181) 2016; 163
Liu, Zhang, Hu, Chen (CR85) 2013; 181
Pandey, Ekka, Ranjan (CR116) 2017; 7
Pillai, Benedetto (CR122) 2018; 10
Benedetto, Bodo, Gontrani, Ballone, Caminiti (CR16) 2014; 118
Evans (CR46) 2008; 112
Luo, San-Hu, Li (CR93) 2010; 73
Magazù, Migliardo, Benedetto (CR100) 2012; 41
Egorova, Seitkalieva, Posvyatenko, Ananikov (CR45) 2015; 4
Magazù, Maisano, Migliardo, Benedetto (CR98) 2008; 882
Banerjee, Ibsen, Brown (CR8) 2018; 115
Łuczak, Jungnickel, Łącka (CR92) 2010; 12
Leitch, Abdelghany, Charlton (CR75) 2020; 202
McLaughlin, Earle, Gîlea (CR107) 2011; 13
Tanner, Wiraja, Curreri (CR155) 2020; 3
Cook, Tarnawsky, Swinton (CR32) 2019; 9
CR151
Kapanidis, Uphoff, Stracy (CR62) 2018; 430
Witos, Russo, Ruokonen, Wiedmer (CR171) 2017; 33
Yoo, Jing, Jones, Lamberti, Zhu, Shah, Maginn (CR175) 2016; 6
Benedetto, Heinrich, Gonzalez (CR17) 2014; 118
Ganapathi, Ganesan (CR50) 2017; 233
Liu, Zhang, Chen (CR88) 2015; 122
Chowdhury, Moshikur, Wakabayashi (CR30) 2019; 565
Bakshi, Mitra, Sharma (CR5) 2020; 1862
Zhang, Malhotra, Francis (CR183) 2014; 264
Welton (CR167) 2018; 10
Deng, Beadham, Ren (CR36) 2020; 194
Li, Ma, Wang (CR77) 2015; 120
Sharma, Ghosh, Mandal (CR138) 2017; 13
Yoo, Zhu, Maginn (CR176) 2016; 32
Stolte, Arning, Bottin-Weber (CR147) 2006; 8
Dharamdasani, Mandal, Qi (CR37) 2020; 323
Modi, Singh, Mahendran (CR108) 2011; 2
Kumar, Malhotra (CR67) 2008; 18
Feng, Zhu, Schurig-Briccio (CR47) 2015; 112
Kumar, Papaïconomou, Lee (CR71) 2009; 24
Sommer, Fister, Gundolf (CR144) 2018; 19
Benedetto, Ballone (CR13) 2016; 4
Magazù, Maisano, Migliardo, Benedetto (CR99) 2010; 1804
Bhattacharya, Giri, Saxena, Agrawal, Gupta, Mukhopadhyay, Ghosh (CR20) 2017; 33
Jing, Li, Zhang, Wang (CR60) 2013; 27
Kashin, Galkin, Khokhlova, Ananikov (CR63) 2016; 55
Cornmell, Winder, Tiddy (CR33) 2008; 10
Wang, Jong, Rühling, Lesch, Shimizu, Wulff, Heuer, Glorius, Galla (CR163) 2016; 32
Petkovic, Seddon, Rebelo, Pereira (CR119) 2011; 40
Egorova, Posvyatenko, Fakhrutdinov (CR44) 2020; 297
Hallett, Welton (CR52) 2011; 111
Piotrowska, Syguda, Wyrwas (CR123) 2017; 167
Bharmoria, Mondal, Pereira (CR19) 2020; 1
Wang, Richter, Rühling, Hüwel, Glorius, Galla (CR162) 2015; 467
Bailey, Townsend, Jernigan (CR7) 2008; 10
Malhotra, Kumar (CR101) 2010; 20
Benedetto, Bingham, Ballone (CR14) 2015; 142
CR117
Silva, Cerqueira, Prudêncio (CR141) 2019; 4
Strahl, Hamoen (CR148) 2010; 107
Mookherjee, Anderson, Haagsman, Davidson (CR110) 2020; 19
Welton (CR166) 1999; 99
Galluzzi, Schulte, Milani, Podestà (CR49) 2018; 34
Tateishi-Karimata, Sugimoto (CR156) 2018; 10
Benedetto, Galla (CR15) 2018; 10
Müller, Wenzel, Strahl (CR111) 2016; 113
Bernot, Kennedy, Lamberti (CR18) 2005; 24
Moniruzzaman, Tahara, Tamura (CR109) 2010; 46
Wang, Galla, Drücker (CR164) 2018; 10
Bai, Da, Li (CR6) 2019; 571
Ranke, Cox, Müller, Schmidt, Beyersmann (CR128) 2006; 88
Liu, Zhu, Wang (CR89) 2015; 285
Pham, Cho, Min, Yun (CR121) 2008; 105
Kohanski, Dwyer, Collins (CR64) 2010; 8
Wang, Ohlin, Lu (CR165) 2007; 9
Blair, Webber, Baylay (CR22) 2015; 13
Li, Zhou, Yu (CR80) 2009; 72
Hough, Smiglak, Rodriguez, Swatloski, Spear, Daly, Pernak, Grisel, Carliss, Soutullo, Davis, Rogers (CR56) 2007; 31
Sioriki, Gaillard, Nahra (CR142) 2019; 4
Stromyer, Southerland, Satyal (CR149) 2020; 185
Benedetto, Ballone (CR11) 2018; 34
Heckenbach, Romero, Green, Halden (CR54) 2016; 150
Li, Jing, Zang (CR79) 2012; 26
Benedetto (CR10) 2017; 9
McClelland, Evans, Abidin (CR106) 2003; 139
Pawłowska, Telesiński, Biczak (CR118) 2019; 237
Hwang, Park, Choi (CR57) 2018; 46
Vraneš, Tot, Ćosić (CR160) 2019; 9
Al-blewi, Rezki, Naqvi (CR2) 2019; 20
Ling, Schneider, Peoples (CR83) 2015; 517
Holm, Borg, Ehrenberg, Sanyal (CR55) 2016; 113
Scott, Whyment, Foster (CR137) 2000; 176
Sivapragasam, Moniruzzaman, Goto (CR143) 2020; 15
Bhattacharya, Mitra, Mandal (CR21) 2018; 10
Rezki, Messali, Al-Sodies (CR131) 2018; 265
Matzke, Stolte, Arning (CR105) 2009; 18
Qi, Mitragotri (CR125) 2019; 311–312
Coleman, Gathergood (CR31) 2010; 39
Samorì, Malferrari, Valbonesi (CR136) 2010; 73
Egorova, Ananikov (CR42) 2014; 7
Ma, Fang, Lu (CR96) 2019; 10
Bubalo, Radošević, Redovniković (CR26) 2017; 68
Malhotra, Kumar, Velez, Zayas (CR102) 2014; 5
Pretti, Chiappe, Pieraccini, Gregori, Abramo, Monni, Intorre (CR124) 2006; 8
Sahbaz, Nguyen, Ford (CR135) 2017; 14
Zhu, Mohapatra, Weisshaar (CR184) 2019; 116
Nandi, English, Futera, Benedetto (CR113) 2017; 19
Andreev, Dupuy, Segala (CR3) 2007; 104
Ma, Cai, Zhang (CR95) 2010; 73
Yu, Wang, Luo (CR179) 2009; 72
Batson, de Chiara, Majce (CR9) 2017; 8
CR186
Shi, Zhao, Gao (CR140) 2020; 322
Radošević, Cvjetko, Kopjar (CR126) 2013; 92
Kumar, Malhotra (CR72) 2009; 19
Stasiewicz, Mulkiewicz, Tomczak-Wandzel (CR145) 2008; 71
Yu, Zhang, Dai (CR180) 2016; 307
Liu, Liu, Wang (CR91) 2018; 622–623
Marrucho, Branco, Rebelo (CR104) 2014; 5
Drücker, Rühling, Grill, Wang, Draeger, Gerke, Glorius, Galla (CR40) 2017; 33
A Müller (754_CR111) 2016; 113
A Benedetto (754_CR12) 2018; 551
M Yu (754_CR178) 2008; 71
D McClelland (754_CR106) 2003; 139
EEL Tanner (754_CR154) 2018; 286
A Piotrowska (754_CR123) 2017; 167
T Liu (754_CR90) 2016; 145
S-K Ruokonen (754_CR133) 2018; 24
R Wan (754_CR161) 2018; 52
VK Sharma (754_CR139) 2018; 10
AS Kashin (754_CR63) 2016; 55
S Stolte (754_CR147) 2006; 8
KS Egorova (754_CR44) 2020; 297
K Bakshi (754_CR5) 2020; 1862
SV Malhotra (754_CR102) 2014; 5
FT Welton (754_CR166) 1999; 99
S Magazù (754_CR99) 2010; 1804
X-Y Li (754_CR78) 2012; 83
X Wang (754_CR165) 2007; 9
Z Yu (754_CR181) 2016; 163
RF Frade (754_CR48) 2010; 29
C Samorì (754_CR136) 2010; 73
C Pretti (754_CR124) 2006; 8
X-Y Li (754_CR80) 2009; 72
GR Young (754_CR177) 2020; 15
S Bornemann (754_CR24) 2020; 22
ME Heckenbach (754_CR54) 2016; 150
G Bhattacharya (754_CR20) 2017; 33
S Wu (754_CR172) 2018; 348
MC Bubalo (754_CR26) 2017; 68
P Drücker (754_CR40) 2017; 33
PK Nandi (754_CR113) 2017; 19
MZ Wilson (754_CR170) 2016; 113
C Jing (754_CR60) 2013; 27
X-Y Li (754_CR79) 2012; 26
Y Sahbaz (754_CR135) 2017; 14
H Liu (754_CR88) 2015; 122
RH Scott (754_CR137) 2000; 176
MR Chowdhury (754_CR30) 2019; 565
M Petkovic (754_CR120) 2012; 36
G Bhattacharya (754_CR21) 2018; 10
LL Ling (754_CR83) 2015; 517
T Takekiyo (754_CR152) 2018; 10
M Kumar (754_CR70) 2011; 24
V Kumar (754_CR72) 2009; 19
QM Qi (754_CR125) 2019; 311–312
T Liu (754_CR86) 2014; 21
B Yoo (754_CR176) 2016; 32
T Liu (754_CR84) 2015; 5
M Dong (754_CR39) 2013; 91
KM Docherty (754_CR38) 2005; 7
P Bharmoria (754_CR19) 2020; 1
Y-R Luo (754_CR93) 2010; 73
B Yoo (754_CR174) 2014; 10
H Liu (754_CR87) 2015; 169
C Zhu (754_CR185) 2020; 5
X-Y Li (754_CR82) 2012; 21
MJ Earle (754_CR41) 2000; 72
D Wang (754_CR162) 2015; 467
L Bui-Le (754_CR27) 2020; 3
J Witos (754_CR171) 2017; 33
M Holm (754_CR55) 2016; 113
RA Kumar (754_CR71) 2009; 24
RJ Bernot (754_CR18) 2005; 24
A Benedetto (754_CR15) 2018; 10
D Wang (754_CR164) 2018; 10
X Li (754_CR76) 2013; 93
P Kumari (754_CR73) 2020; 11
A Pandey (754_CR116) 2017; 7
AT Silva (754_CR141) 2019; 4
754_CR151
C Zhang (754_CR183) 2014; 264
VR Thamke (754_CR157) 2019; 250
H Tateishi-Karimata (754_CR156) 2018; 10
N Modi (754_CR108) 2011; 2
Y Shi (754_CR140) 2020; 322
B Pawłowska (754_CR118) 2019; 237
T Welton (754_CR167) 2018; 10
T Liu (754_CR89) 2015; 285
M Wenzel (754_CR168) 2014; 111
S Magazù (754_CR100) 2012; 41
D Coleman (754_CR31) 2010; 39
AC Leitch (754_CR74) 2020; 136
T Hattori (754_CR53) 2019; 9
C Rotella (754_CR132) 2018; 10
M Matzke (754_CR105) 2009; 18
KS Egorova (754_CR45) 2015; 4
B Yoo (754_CR175) 2016; 6
VK Sharma (754_CR138) 2017; 13
Y Zhu (754_CR184) 2019; 116
C Agatemor (754_CR1) 2018; 3
H Strahl (754_CR148) 2010; 107
JMA Blair (754_CR22) 2015; 13
A Benedetto (754_CR14) 2015; 142
M Cvjetko Bubalo (754_CR35) 2014; 101
A Kumar (754_CR68) 2014; 49
J Ranke (754_CR128) 2006; 88
S Bai (754_CR6) 2019; 571
M Petkovic (754_CR119) 2011; 40
J Hwang (754_CR57) 2018; 46
J Łuczak (754_CR92) 2010; 12
N Mookherjee (754_CR110) 2020; 19
Y Xu (754_CR173) 2020; 240
SPF Costa (754_CR34) 2017; 10
F Grein (754_CR51) 2020; 11
M Sivapragasam (754_CR143) 2020; 15
VR Thamke (754_CR159) 2017; 125
A Benedetto (754_CR13) 2016; 4
RJ Cornmell (754_CR33) 2008; 10
J Marks (754_CR103) 2016; 113
J Ranke (754_CR129) 2007; 67
S Magazù (754_CR98) 2008; 882
MG Rees (754_CR130) 2016; 12
M McLaughlin (754_CR107) 2011; 13
A Benedetto (754_CR10) 2017; 9
HD Williams (754_CR169) 2014; 50
M Zakrewsky (754_CR182) 2014; 111
J Stoimenovski (754_CR146) 2012; 154
MM Bailey (754_CR7) 2008; 10
J Mwangi (754_CR112) 2019; 116
I Kontro (754_CR65) 2016; 201
J Ranke (754_CR127) 2004; 58
Cook (754_CR32) 2019; 9
X-Y Li (754_CR81) 2010; 78
V Dharamdasani (754_CR37) 2020; 323
TPT Pham (754_CR121) 2008; 105
KA Brogden (754_CR25) 2005; 3
D Liu (754_CR91) 2018; 622–623
M Stasiewicz (754_CR145) 2008; 71
M Yu (754_CR179) 2009; 72
IM Marrucho (754_CR104) 2014; 5
S Batson (754_CR9) 2017; 8
SV Malhotra (754_CR101) 2010; 20
C Jing (754_CR59) 2014; 33
KS Egorova (754_CR43) 2017; 117
X Li (754_CR77) 2015; 120
KN Ibsen (754_CR58) 2018; 4
A Banerjee (754_CR8) 2018; 115
754_CR186
G Chantereau (754_CR29) 2020; 302
H Ryu (754_CR134) 2015; 5
B Ma (754_CR96) 2019; 10
D Wang (754_CR163) 2016; 32
Y-R Luo (754_CR94) 2009; 77
K Maddali (754_CR97) 2011; 2
JP Hallett (754_CR52) 2011; 111
VVS Pillai (754_CR122) 2018; 10
KS Egorova (754_CR42) 2014; 7
S Studzińska (754_CR150) 2009; 393
M Vraneš (754_CR160) 2019; 9
J Jodynis-Liebert (754_CR61) 2010; 57
EEL Tanner (754_CR155) 2020; 3
M Blesic (754_CR23) 2007; 9
H Liu (754_CR85) 2013; 181
J Sommer (754_CR144) 2018; 19
K Radošević (754_CR126) 2013; 92
J Yu (754_CR180) 2016; 307
X Feng (754_CR47) 2015; 112
AN Kapanidis (754_CR62) 2018; 430
V Kumar (754_CR67) 2008; 18
754_CR117
M Galluzzi (754_CR49) 2018; 34
F Al-blewi (754_CR2) 2019; 20
ML Stromyer (754_CR149) 2020; 185
E Sioriki (754_CR142) 2019; 4
KO Evans (754_CR46) 2008; 112
P Ganapathi (754_CR50) 2017; 233
M Moniruzzaman (754_CR109) 2010; 46
B Bachowska (754_CR4) 2012; 1
M Nurunnabi (754_CR114) 2019; 116
L Carson (754_CR28) 2009; 11
N Rezki (754_CR131) 2018; 265
A Benedetto (754_CR16) 2014; 118
J-M Ma (754_CR95) 2010; 73
EEL Tanner (754_CR153) 2019; 31
Y Deng (754_CR36) 2020; 194
MA Kohanski (754_CR64) 2010; 8
B Kudłak (754_CR66) 2015; 22
G O’Toole (754_CR115) 2012; 31
VR Thamke (754_CR158) 2016; 320
A Kumar (754_CR69) 2017; 69
OA Andreev (754_CR3) 2007; 104
A Benedetto (754_CR11) 2018; 34
A Benedetto (754_CR17) 2014; 118
WL Hough (754_CR56) 2007; 31
AC Leitch (754_CR75) 2020; 202
References_xml – volume: 10
  start-page: 847
  year: 2018
  end-page: 852
  ident: CR122
  article-title: Ionic liquids in protein amyloidogenesis: a brief screenshot of the state-of-the-art
  publication-title: Biophys Rev
  doi: 10.1007/s12551-018-0425-4
– volume: 36
  start-page: 56
  year: 2012
  end-page: 63
  ident: CR120
  article-title: Unravelling the mechanism of toxicity of alkyltributylphosphonium chlorides in Aspergillus nidulans conidia
  publication-title: New J Chem
  doi: 10.1039/C1NJ20470J
– volume: 19
  start-page: 311
  year: 2020
  end-page: 332
  ident: CR110
  article-title: Antimicrobial host defence peptides: functions and clinical potential
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/s41573-019-0058-8
– volume: 15
  start-page: e0229745
  year: 2020
  ident: CR177
  article-title: Changes in the gut microbiota of mice orally exposed to methylimidazolium ionic liquids
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0229745
– volume: 348
  start-page: 1
  year: 2018
  end-page: 9
  ident: CR172
  article-title: Assessment of the cytotoxicity of ionic liquids on Spodoptera frugiperda 9 (Sf-9) cell lines via in vitro assays
  publication-title: J Hazard Mater
  doi: 10.1016/j.jhazmat.2018.01.028
– volume: 10
  start-page: 687
  year: 2018
  end-page: 690
  ident: CR15
  article-title: Editorial of the “ionic liquids and biomolecules” special issue
  publication-title: Biophys Rev
  doi: 10.1007/s12551-018-0426-3
– volume: 2
  start-page: 2331
  year: 2011
  end-page: 2336
  ident: CR108
  article-title: Probing the transport of ionic liquids in aqueous solution through nanopores
  publication-title: J Phys Chem Lett
  doi: 10.1021/jz201006b
– volume: 33
  start-page: 1066
  year: 2017
  end-page: 1076
  ident: CR171
  article-title: Unraveling interactions between ionic liquids and phospholipid vesicles using nanoplasmonic sensing
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.6b04359
– volume: 49
  start-page: 2158
  year: 2014
  end-page: 2169
  ident: CR68
  article-title: A comparative study of myoglobin stability in the presence of Hofmeister anions of ionic liquids and ionic salts
  publication-title: Process Biochem
  doi: 10.1016/j.procbio.2014.09.014
– volume: 250
  start-page: 567
  year: 2019
  end-page: 577
  ident: CR157
  article-title: In vitro toxicological evaluation of ionic liquids and development of effective bioremediation process for their removal
  publication-title: Environ Pollut
  doi: 10.1016/j.envpol.2019.04.043
– volume: 9
  start-page: 481
  year: 2007
  end-page: 490
  ident: CR23
  article-title: Self-aggregation of ionic liquids: micelle formation in aqueous solution
  publication-title: Green Chem
  doi: 10.1039/b615406a
– volume: 111
  start-page: 3508
  year: 2011
  end-page: 3576
  ident: CR52
  article-title: Room-temperature ionic liquids: solvents for synthesis and catalysis. 2
  publication-title: Chem Rev
  doi: 10.1021/cr1003248
– volume: 12
  start-page: 109
  year: 2016
  end-page: 116
  ident: CR130
  article-title: Correlating chemical sensitivity and basal gene expression reveals mechanism of action
  publication-title: Nat Chem Biol
  doi: 10.1038/nchembio.1986
– volume: 176
  start-page: 119
  year: 2000
  end-page: 131
  ident: CR137
  article-title: Analysis of the structure and electrophysiological actions of halitoxins: 1,3 alkyl-pyridinium salts from Callyspongia ridleyi
  publication-title: J Membr Biol
  doi: 10.1007/s00232001078
– volume: 67
  start-page: 430
  year: 2007
  end-page: 438
  ident: CR129
  article-title: Lipophilicity parameters for ionic liquid cations and their correlation to in vitro cytotoxicity
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2006.08.008
– volume: 11
  start-page: 7327
  year: 2020
  end-page: 7333
  ident: CR73
  article-title: Sub-toxic concentrations of ionic liquids enhance cell migration by reducing the elasticity of the cellular lipid membrane
  publication-title: J Phys Chem Lett
  doi: 10.1021/acs.jpclett.0c02149
– volume: 8
  start-page: 423
  year: 2010
  end-page: 435
  ident: CR64
  article-title: How antibiotics kill bacteria: from targets to networks
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro2333
– volume: 112
  start-page: E7073
  year: 2015
  end-page: E7082
  ident: CR47
  article-title: Antiinfectives targeting enzymes and the proton motive force
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1521988112
– volume: 12
  start-page: 593
  year: 2010
  ident: CR92
  article-title: Antimicrobial and surface activity of 1-alkyl-3-methylimidazolium derivatives
  publication-title: Green Chem
  doi: 10.1039/b921805j
– volume: 72
  start-page: 552
  year: 2009
  end-page: 556
  ident: CR80
  article-title: Toxic effects of 1-methyl-3-octylimidazolium bromide on the early embryonic development of the frog Rana nigromaculata
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2007.11.002
– volume: 4
  start-page: 2370
  year: 2018
  end-page: 2379
  ident: CR58
  article-title: Mechanism of antibacterial activity of choline-based ionic liquids (CAGE)
  publication-title: ACS Biomater Sci Eng
  doi: 10.1021/acsbiomaterials.8b00486
– volume: 34
  start-page: 9579
  year: 2018
  end-page: 9597
  ident: CR11
  article-title: Room-temperature ionic liquids and biomembranes: setting the stage for applications in pharmacology, biomedicine, and bionanotechnology
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.7b04361
– volume: 551
  start-page: 227
  year: 2018
  end-page: 231
  ident: CR12
  article-title: An overview of neutron scattering and molecular dynamics simulation studies of phospholipid bilayers in room-temperature ionic liquid/water solutions
  publication-title: Phys B Condens Matter
  doi: 10.1016/j.physb.2018.02.043
– volume: 73
  start-page: 1465
  year: 2010
  end-page: 1469
  ident: CR95
  article-title: Acute toxicity and effects of 1-alkyl-3-methylimidazolium bromide ionic liquids on green algae
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2009.10.004
– volume: 1
  start-page: 34
  year: 2020
  ident: CR19
  article-title: Instantaneous fibrillation of egg white proteome with ionic liquid and macromolecular crowding
  publication-title: Commun Mater
  doi: 10.1038/s43246-020-0035-0
– volume: 10
  start-page: 751
  year: 2018
  end-page: 756
  ident: CR132
  article-title: Controlling the mechanoelasticity of model biomembranes with room-temperature ionic liquids
  publication-title: Biophys Rev
  doi: 10.1007/s12551-018-0424-5
– volume: 107
  start-page: 12281
  year: 2010
  end-page: 12286
  ident: CR148
  article-title: Membrane potential is important for bacterial cell division
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1005485107
– volume: 24
  start-page: 388
  year: 2009
  end-page: 395
  ident: CR71
  article-title: In vitro cytotoxicities of ionic liquids: effect of cation rings, functional groups, and anions
  publication-title: Environ Toxicol
  doi: 10.1002/tox.20443
– volume: 9
  start-page: 309
  year: 2017
  end-page: 320
  ident: CR10
  article-title: Room-temperature ionic liquids meet bio-membranes: the state-of-the-art
  publication-title: Biophys Rev
  doi: 10.1007/s12551-017-0279-1
– volume: 19
  start-page: 790
  year: 2018
  ident: CR144
  article-title: Virucidal or not virucidal? That is the question—predictability of ionic liquid’s virucidal potential in biological test systems
  publication-title: IJMS
  doi: 10.3390/ijms19030790
– volume: 3
  start-page: 238
  year: 2005
  end-page: 250
  ident: CR25
  article-title: Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria?
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro1098
– volume: 104
  start-page: 7893
  year: 2007
  end-page: 7898
  ident: CR3
  article-title: Mechanism and uses of a membrane peptide that targets tumors and other acidic tissues in vivo
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.0702439104
– volume: 112
  start-page: 8558
  year: 2008
  end-page: 8562
  ident: CR46
  article-title: Supported phospholipid membrane interactions with 1- butyl-3-methylimidazolium chloride
  publication-title: J Phys Chem B
  doi: 10.1021/jp7116592
– volume: 285
  start-page: 27
  year: 2015
  end-page: 36
  ident: CR89
  article-title: The genotoxic and cytotoxic effects of 1-butyl-3-methylimidazolium chloride in soil on Vicia faba seedlings
  publication-title: J Hazard Mater
  doi: 10.1016/j.jhazmat.2014.11.028
– volume: 24
  start-page: 2669
  year: 2018
  end-page: 2680
  ident: CR133
  article-title: Correlation between ionic liquid cytotoxicity and liposome-ionic liquid interactions
  publication-title: Chem Eur J
  doi: 10.1002/chem.201704924
– volume: 467
  start-page: 1033
  year: 2015
  end-page: 1038
  ident: CR162
  article-title: Anti-tumor activity and cytotoxicity in vitro of novel 4,5-dialkyli- midazolium surfactants
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2015.10.015
– volume: 46
  start-page: 194
  year: 2018
  end-page: 202
  ident: CR57
  article-title: Investigation of dermal toxicity of ionic liquids in monolayer-cultured skin cells and 3D reconstructed human skin models
  publication-title: Toxicol in Vitro
  doi: 10.1016/j.tiv.2017.09.025
– volume: 145
  start-page: 269
  year: 2016
  end-page: 276
  ident: CR90
  article-title: Phytotoxicity of imidazolium-based ILs with different anions in soil on Vicia faba seedlings and the influence of anions on toxicity
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2015.11.055
– volume: 13
  start-page: 8969
  year: 2017
  end-page: 8979
  ident: CR138
  article-title: Effects of ionic liquids on the nanoscopic dynamics and phase behaviour of a phosphatidylcholine membrane
  publication-title: Soft Matter
  doi: 10.1039/C7SM01799E
– volume: 194
  start-page: 110392
  year: 2020
  ident: CR36
  article-title: A study into the species sensitivity of green algae towards imidazolium-based ionic liquids using flow cytometry
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2020.110392
– volume: 882
  start-page: 140
  year: 2008
  end-page: 145
  ident: CR98
  article-title: Mean square displacement from self-distribution function evaluation by elastic incoherent neutron scattering
  publication-title: J Mol Struct
  doi: 10.1016/j.molstruc.2007.09.022
– volume: 118
  start-page: 12192
  year: 2014
  end-page: 12206
  ident: CR17
  article-title: Structure and stability of phospholipid bilayers hydrated by a room-temperature ionic liquid/water solution: a neutron reflectometry study
  publication-title: J Phys Chem B
  doi: 10.1021/jp507631h
– volume: 10
  start-page: 735
  year: 2018
  end-page: 746
  ident: CR164
  article-title: Membrane interactions of ionic liquids and imidazolium salts
  publication-title: Biophys Rev
  doi: 10.1007/s12551-017-0388-x
– volume: 233
  start-page: 452
  year: 2017
  end-page: 464
  ident: CR50
  article-title: Anti-bacterial, catalytic and docking behaviours of novel di/trimeric imidazolium salts
  publication-title: J Mol Liq
  doi: 10.1016/j.molliq.2017.02.078
– volume: 22
  start-page: 11975
  year: 2015
  end-page: 11992
  ident: CR66
  article-title: Selected issues related to the toxicity of ionic liquids and deep eutectic solvents—a review
  publication-title: Environ Sci Pollut Res
  doi: 10.1007/s11356-015-4794-y
– volume: 71
  start-page: 903
  year: 2008
  end-page: 908
  ident: CR178
  article-title: Acute effects of 1-octyl-3-methylimidazolium bromide ionic liquid on the antioxidant enzyme system of mouse liver
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2008.02.022
– volume: 7
  start-page: 22927
  year: 2017
  end-page: 22935
  ident: CR116
  article-title: Teratogenic, cardiotoxic and hepatotoxic properties of related ionic liquids reveal the biological importance of anionic components
  publication-title: RSC Adv
  doi: 10.1039/C7RA01520H
– volume: 6
  start-page: 19889
  year: 2016
  ident: CR175
  article-title: Molecular mechanisms of ionic liquid cytotoxicity probed by an integrated experimental and computational approach
  publication-title: Sci Rep
  doi: 10.1038/srep19889
– volume: 7
  start-page: 185
  year: 2005
  ident: CR38
  article-title: Toxicity and antimicrobial activity of imidazolium and pyridinium ionic liquids
  publication-title: Green Chem
  doi: 10.1039/b419172b
– volume: 320
  start-page: 408
  year: 2016
  end-page: 416
  ident: CR158
  article-title: Toxicity study of ionic liquid, 1-butyl-3-methylimidazolium bromide on guppy fish, Poecilia reticulata and its biodegradation by soil bacterium Rhodococcus hoagii VRT1
  publication-title: J Hazard Mater
  doi: 10.1016/j.jhazmat.2016.08.056
– volume: 115
  start-page: 7296
  year: 2018
  end-page: 7301
  ident: CR8
  article-title: Ionic liquids for oral insulin delivery
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1722338115
– volume: 9
  start-page: 1191
  year: 2007
  ident: CR165
  article-title: Cytotoxicity of ionic liquids and precursor compounds towards human cell line HeLa
  publication-title: Green Chem
  doi: 10.1039/b704503d
– ident: CR117
– volume: 8
  start-page: 238
  year: 2006
  end-page: 240
  ident: CR124
  article-title: Acute toxicity of ionic liquids to the zebrafish (Danio Rerio)
  publication-title: Green Chem
  doi: 10.1039/B511554J
– volume: 88
  start-page: 273
  year: 2006
  end-page: 285
  ident: CR128
  article-title: Sorption, cellular distribution, and cytotoxicity of imidazolium ionic liquids in mammalian cells—influence of lipophilicity
  publication-title: Toxicol Environ Chem
  doi: 10.1080/02772240600589505
– volume: 393
  start-page: 983
  year: 2009
  end-page: 990
  ident: CR150
  article-title: Study of toxicity of imidazolium ionic liquids to watercress (Lepidium sativum L.)
  publication-title: Anal Bioanal Chem
  doi: 10.1007/s00216-008-2523-9
– volume: 58
  start-page: 396
  year: 2004
  end-page: 404
  ident: CR127
  article-title: Biological effects of imidazolium ionic liquids with varying chain lengths in acute Vibrio fischeri and WST-1 cell viability assays
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/S0147-6513(03)00105-2
– volume: 24
  start-page: 1882
  year: 2011
  end-page: 1890
  ident: CR70
  article-title: Toxic effects of imidazolium ionic liquids on the green seaweed Ulva lactuca: oxidative stress and DNA damage
  publication-title: Chem Res Toxicol
  doi: 10.1021/tx200228c
– volume: 323
  start-page: 475
  year: 2020
  end-page: 482
  ident: CR37
  article-title: Topical delivery of siRNA into skin using ionic liquids
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2020.04.038
– volume: 8
  start-page: 1939
  year: 2017
  ident: CR9
  article-title: Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine
  publication-title: Nat Commun
  doi: 10.1038/s41467-017-02118-7
– volume: 26
  start-page: 1087
  year: 2012
  end-page: 1092
  ident: CR79
  article-title: Toxic cytological alteration and mitochondrial dysfunction in PC12 cells induced by 1-octyl-3-methylimidazolium chloride
  publication-title: Toxicol in Vitro
  doi: 10.1016/j.tiv.2012.07.006
– volume: 10
  start-page: 691
  year: 2018
  end-page: 706
  ident: CR167
  article-title: Ionic liquids: a brief history
  publication-title: Biophys Rev
  doi: 10.1007/s12551-018-0419-2
– volume: 307
  start-page: 73
  year: 2016
  end-page: 81
  ident: CR180
  article-title: Antimicrobial activity and cytotoxicity of piperazinium- and guanidinium-based ionic liquids
  publication-title: J Hazard Mater
  doi: 10.1016/j.jhazmat.2015.12.028
– volume: 2
  start-page: 143
  year: 2011
  end-page: 150
  ident: CR97
  article-title: Biological evaluation of imidazolium- and ammonium-based salts as HIV-1 integrase inhibitors
  publication-title: Med Chem Commun
  doi: 10.1039/C0MD00201A
– volume: 105
  start-page: 425
  year: 2008
  end-page: 428
  ident: CR121
  article-title: Alkyl-chain length effects of imidazolium and pyridinium ionic liquids on photosynthetic response of Pseudokirchneriella subcapitata
  publication-title: J Biosci Bioeng
  doi: 10.1263/jbb.105.425
– volume: 11
  start-page: 1455
  year: 2020
  ident: CR51
  article-title: Ca2+-daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-15257-1
– volume: 10
  start-page: 2321
  year: 2017
  end-page: 2347
  ident: CR34
  article-title: Environmental impact of ionic liquids: recent advances in (eco)toxicology and (bio)degradability
  publication-title: ChemSusChem
  doi: 10.1002/cssc.201700261
– volume: 93
  start-page: 2488
  year: 2013
  end-page: 2492
  ident: CR76
  article-title: Expression alterations of cytochromes P4501A1, 2E1, and 3A, and their receptors AhR and PXR caused by 1-octyl-3-methylimidazolium chloride in mouse mammary carcinoma cells
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2013.08.092
– volume: 122
  start-page: 83
  year: 2015
  end-page: 90
  ident: CR88
  article-title: Effects of imidazolium chloride ionic liquids and their toxicity to Scenedesmus obliquus
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2015.07.010
– volume: 622–623
  start-page: 1572
  year: 2018
  end-page: 1580
  ident: CR91
  article-title: The toxicity of ionic liquid 1-decylpyridinium bromide to the algae Scenedesmus obliquus: growth inhibition, phototoxicity, and oxidative stress
  publication-title: Sci Total Environ
  doi: 10.1016/j.scitotenv.2017.10.021
– ident: CR151
– volume: 3
  start-page: 2000041
  year: 2020
  ident: CR155
  article-title: Stabilization and topical skin delivery of framework nucleic acids using ionic liquids
  publication-title: Adv Therap
  doi: 10.1002/adtp.202000041
– volume: 52
  start-page: 1
  year: 2018
  end-page: 7
  ident: CR161
  article-title: Toxicity of imidazoles ionic liquid [C16mim]Cl to HepG2 cells
  publication-title: Toxicol in Vitro
  doi: 10.1016/j.tiv.2018.05.013
– volume: 113
  start-page: 978
  year: 2016
  end-page: 983
  ident: CR55
  article-title: Molecular mechanism of viomycin inhibition of peptide elongation in bacteria
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1517541113
– volume: 71
  start-page: 157
  year: 2008
  end-page: 165
  ident: CR145
  article-title: Assessing toxicity and biodegradation of novel, environmentally benign ionic liquids (1-alkoxymethyl-3-hydroxypyridinium chloride, saccharinate and acesulfamates) on cellular and molecular level
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2007.08.011
– volume: 10
  start-page: 931
  year: 2018
  end-page: 940
  ident: CR156
  article-title: Biological and nanotechnological applications using interactions between ionic liquids and nucleic acids
  publication-title: Biophys Rev
  doi: 10.1007/s12551-018-0422-7
– volume: 7
  start-page: 336
  year: 2014
  end-page: 360
  ident: CR42
  article-title: Toxicity of ionic liquids: eco(cyto)activity as complicated, but unavoidable parameter for task-specific optimization
  publication-title: ChemSusChem
  doi: 10.1002/cssc.201300459
– volume: 10
  start-page: 1213
  year: 2008
  ident: CR7
  article-title: Developmental toxicity assessment of the ionic liquid 1-butyl-3-methylimidazolium chloride in CD-1 mice
  publication-title: Green Chem
  doi: 10.1039/b807019a
– volume: 69
  start-page: 611
  year: 2017
  end-page: 651
  ident: CR69
  article-title: Biocompatibility of ionic liquids towards protein stability: a comprehensive overview on the current understanding and their implications
  publication-title: Int J Biol Macromol
  doi: 10.1016/j.ijbiomac.2016.12.005
– volume: 1862
  start-page: 183103
  year: 2020
  ident: CR5
  article-title: Imidazolium-based ionic liquids cause mammalian cell death due to modulated structures and dynamics of cellular membrane
  publication-title: Biochim Biophys Acta Biomembr
  doi: 10.1016/j.bbamem.2019.183103
– volume: 169
  start-page: 179
  year: 2015
  end-page: 187
  ident: CR87
  article-title: Enantioselective toxicities of chiral ionic liquids 1-alkyl-3-methyl imidazolium tartrate on Scenedesmus obliquus
  publication-title: Aquat Toxicol
  doi: 10.1016/j.aquatox.2015.10.024
– volume: 265
  start-page: 428
  year: 2018
  end-page: 441
  ident: CR131
  article-title: Design, synthesis, in-silico and in-vitro evaluation of di-cationic pyridinium ionic liquids as potential anticancer scaffolds
  publication-title: J Mol Liq
  doi: 10.1016/j.molliq.2018.06.045
– volume: 264
  start-page: 246
  year: 2014
  end-page: 253
  ident: CR183
  article-title: Toxicity of ionic liquids to Clostridium sp. and effects on uranium biosorption
  publication-title: J Hazard Mater
  doi: 10.1016/j.jhazmat.2013.11.003
– volume: 167
  start-page: 114
  year: 2017
  end-page: 119
  ident: CR123
  article-title: Toxicity evaluation of selected ammonium-based ionic liquid forms with MCPP and dicamba moieties on Pseudomonas putida
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2016.09.140
– volume: 201
  start-page: 59
  year: 2016
  end-page: 66
  ident: CR65
  article-title: Effects of phosphonium-based ionic liquids on phospholipid membranes studied by small-angle X-ray scattering
  publication-title: Chem Phys Lipids
  doi: 10.1016/j.chemphyslip.2016.11.003
– volume: 10
  start-page: 3517
  year: 2019
  ident: CR96
  article-title: The antimicrobial peptide thanatin disrupts the bacterial outer membrane and inactivates the NDM-1 metallo-β-lactamase
  publication-title: Nat Commun
  doi: 10.1038/s41467-019-11503-3
– volume: 118
  start-page: 2471
  year: 2014
  end-page: 2486
  ident: CR16
  article-title: Amino acid anions in organic ionic compounds. An ab initio study of selected ion pairs
  publication-title: J Phys Chem
  doi: 10.1021/jp412281n
– volume: 21
  start-page: 253
  year: 2012
  end-page: 259
  ident: CR82
  article-title: Acute toxicity and responses of antioxidant systems to 1-methyl-3-octylimidazolium bromide at different developmental stages of goldfish
  publication-title: Ecotoxicology
  doi: 10.1007/s10646-011-0785-z
– volume: 4
  start-page: 152
  year: 2015
  end-page: 159
  ident: CR45
  article-title: An unexpected increase of toxicity of amino acid-containing ionic liquids
  publication-title: Toxicol Res
  doi: 10.1039/C4TX00079J
– volume: 13
  start-page: 2794
  year: 2011
  ident: CR107
  article-title: Cytotoxicity of 1-alkylquinolinium bromide ionic liquids in murine fibroblast NIH 3 T3 cells
  publication-title: Green Chem
  doi: 10.1039/c0gc00813c
– volume: 40
  start-page: 1383
  year: 2011
  end-page: 1403
  ident: CR119
  article-title: Ionic liquids: a pathway to environmental acceptability
  publication-title: Chem Soc Rev
  doi: 10.1039/C004968A
– volume: 5
  start-page: 18444
  year: 2015
  ident: CR84
  article-title: Biochemical toxicity and DNA damage of imidazolium-based ionic liquid with different anions in soil on Vicia faba seedlings
  publication-title: Sci Rep
  doi: 10.1038/srep18444
– volume: 10
  start-page: 836
  year: 2008
  ident: CR33
  article-title: Accumulation of ionic liquids in Escherichia coli cells
  publication-title: Green Chem
  doi: 10.1039/b807214k
– volume: 111
  start-page: E1409
  year: 2014
  end-page: E1418
  ident: CR168
  article-title: Small cationic antimicrobial peptides delocalize peripheral membrane proteins
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1319900111
– volume: 4
  start-page: 5682
  year: 2019
  end-page: 5689
  ident: CR141
  article-title: Antiproliferative organic salts derived from betulinic acid: disclosure of an ionic liquid selective against lung and liver cancer cells
  publication-title: ACS Omega
  doi: 10.1021/acsomega.8b03691
– ident: CR186
– volume: 39
  start-page: 600
  year: 2010
  ident: CR31
  article-title: Biodegradation studies of ionic liquids
  publication-title: Chem Soc Rev
  doi: 10.1039/b817717c
– volume: 286
  start-page: 137
  year: 2018
  end-page: 144
  ident: CR154
  article-title: Transdermal insulin delivery using choline-based ionic liquids (CAGE)
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2018.07.029
– volume: 297
  start-page: 111751
  year: 2020
  ident: CR44
  article-title: Assessing possible influence of structuring effects in solution on cytotoxicity of ionic liquid systems
  publication-title: J Mol Liq
  doi: 10.1016/j.molliq.2019.111751
– volume: 73
  start-page: 1046
  year: 2010
  end-page: 1050
  ident: CR93
  article-title: Toxicity of ionic liquids on the growth, reproductive ability, and ATPase activity of earthworm
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2010.01.017
– volume: 20
  start-page: 2865
  year: 2019
  ident: CR2
  article-title: A profile of the in vitro anti-tumor activity and in silico ADME predictions of novel benzothiazole amide-functionalized imidazolium ionic liquids
  publication-title: IJMS
  doi: 10.3390/ijms20122865
– volume: 34
  start-page: 12452
  year: 2018
  end-page: 12462
  ident: CR49
  article-title: Imidazolium-based ionic liquids affect morphology and rigidity of living cells: an atomic force microscopy study
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.8b01554
– volume: 32
  start-page: 12579
  year: 2016
  end-page: 12592
  ident: CR163
  article-title: Imidazolium-based lipid analogues and their interaction with phosphatidylcholine membranes
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.6b02496
– volume: 22
  start-page: 9775
  year: 2020
  end-page: 9788
  ident: CR24
  article-title: Interaction of imidazolium-based lipids with phospholipid bilayer membranes of different complexity
  publication-title: Phys Chem Chem Phys
  doi: 10.1039/D0CP00801J
– volume: 322
  start-page: 602
  year: 2020
  end-page: 609
  ident: CR140
  article-title: Oral delivery of sorafenib through spontaneous formation of ionic liquid nanocomplexes
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2020.03.018
– volume: 33
  start-page: 1295
  year: 2017
  end-page: 1304
  ident: CR20
  article-title: X-ray reflectivity study of the interaction of an imidazolium-based ionic liquid with a soft supported lipid membrane
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.6b03192
– volume: 139
  start-page: 1399
  year: 2003
  end-page: 1408
  ident: CR106
  article-title: Irreversible and reversible pore formation by polymeric alkylpyridinium salts (poly-APS) from the sponge Reniera sarai
  publication-title: Br J Pharmacol
  doi: 10.1038/sj.bjp.0705374
– volume: 311–312
  start-page: 162
  year: 2019
  end-page: 169
  ident: CR125
  article-title: Mechanistic study of transdermal delivery of macromolecules assisted by ionic liquids
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2019.08.029
– volume: 240
  start-page: 124919
  year: 2020
  ident: CR173
  article-title: Toxicity evaluation of three imidazolium-based ionic liquids ([C6mim]R) on Vicia faba seedlings using an integrated biomarker response (IBR) index
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2019.124919
– volume: 31
  start-page: 1901103
  year: 2019
  ident: CR153
  article-title: Design principles of ionic liquids for transdermal drug delivery
  publication-title: Adv Mater
  doi: 10.1002/adma.201901103
– volume: 24
  start-page: 1759
  year: 2005
  ident: CR18
  article-title: Effects of ionic liquids on the survival, movement, and feeding behavior of the freshwater snail, Physa Acuta
  publication-title: Environ Toxicol Chem
  doi: 10.1897/04-614R.1
– volume: 10
  start-page: 709
  year: 2018
  end-page: 719
  ident: CR21
  article-title: Thermodynamics of interaction of ionic liquids with lipid monolayer
  publication-title: Biophys Rev
  doi: 10.1007/s12551-017-0390-3
– volume: 117
  start-page: 7132
  year: 2017
  end-page: 7189
  ident: CR43
  article-title: Biological activity of ionic liquids and their application in pharmaceutics and medicine
  publication-title: Chem Rev
  doi: 10.1021/acs.chemrev.6b00562
– volume: 10
  start-page: 853
  year: 2018
  end-page: 860
  ident: CR152
  article-title: Suppression and dissolution of amyloid aggregates using ionic liquids
  publication-title: Biophys Rev
  doi: 10.1007/s12551-018-0421-8
– volume: 78
  start-page: 853
  year: 2010
  end-page: 858
  ident: CR81
  article-title: Effects of 1-methyl-3-octylimidazolium bromide on the anti-oxidant system of earthworm
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2009.11.047
– volume: 1
  start-page: 33
  year: 2012
  end-page: 38
  ident: CR4
  article-title: High cytotoxic activity of phosphonium salts and their complementary selectivity towards HeLa and K562 cancer cells: identification of tri-n-butyl-n-hexadecylphosphonium bromide as a highly potent anti-HeLa phosphonium salt
  publication-title: ChemistryOpen
  doi: 10.1002/open.201100003
– volume: 150
  start-page: 266
  year: 2016
  end-page: 274
  ident: CR54
  article-title: Meta-analysis of ionic liquid literature and toxicology
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2016.02.029
– volume: 33
  start-page: 91
  year: 2014
  end-page: 94
  ident: CR59
  article-title: Cytotoxicity of 1-octyl-3-methylimidazolium chloride on Escherichia coli DH5α
  publication-title: Toxin Rev
  doi: 10.3109/15569543.2013.867885
– volume: 15
  start-page: 1900073
  year: 2020
  ident: CR143
  article-title: An overview on the toxicological properties of ionic liquids toward microorganisms
  publication-title: Biotechnol J
  doi: 10.1002/biot.201900073
– volume: 13
  start-page: 42
  year: 2015
  end-page: 51
  ident: CR22
  article-title: Molecular mechanisms of antibiotic resistance
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro3380
– volume: 5
  start-page: 527
  year: 2014
  end-page: 546
  ident: CR104
  article-title: Ionic liquids in pharmaceutical applications
  publication-title: Annu Rev Chem Biomol Eng
  doi: 10.1146/annurev-chembioeng-060713-040024
– volume: 142
  start-page: 124706
  year: 2015
  ident: CR14
  article-title: Structure and dynamics of POPC bilayers in water solutions of room temperature ionic liquids
  publication-title: J Chem Phys
  doi: 10.1063/1.4915918
– volume: 4
  start-page: 392
  year: 2016
  end-page: 412
  ident: CR13
  article-title: Room temperature ionic liquids meet biomolecules: a microscopic view of structure and dynamics
  publication-title: ACS Sustain Chem Eng
  doi: 10.1021/acssuschemeng.5b01385
– volume: 31
  start-page: 1429
  year: 2007
  end-page: 1436
  ident: CR56
  article-title: The third evolution of ionic liquids: active pharmaceutical ingredients
  publication-title: New J Chem
  doi: 10.1039/b706677p
– volume: 57
  start-page: 266
  year: 2010
  end-page: 273
  ident: CR61
  article-title: Cytotoxicity, acute and subchronic toxicity of ionic liquid, didecyldimethylammonium saccharinate, in rats
  publication-title: Regul Toxicol Pharmacol
  doi: 10.1016/j.yrtph.2010.03.006
– volume: 125
  start-page: 237
  year: 2017
  end-page: 248
  ident: CR159
  article-title: Evaluation of risk assessment of new industrial pollutant, ionic liquids on environmental living systems
  publication-title: Water Res
  doi: 10.1016/j.watres.2017.08.046
– volume: 10
  start-page: 721
  year: 2018
  end-page: 734
  ident: CR139
  article-title: Deciphering interactions of ionic liquids with biomembrane
  publication-title: Biophys Rev
  doi: 10.1007/s12551-018-0410-y
– volume: 3
  start-page: 55
  year: 2020
  ident: CR27
  article-title: Revealing the complexity of ionic liquid–protein interactions through a multi-technique investigation
  publication-title: Commun Chem
  doi: 10.1038/s42004-020-0302-5
– volume: 302
  start-page: 112547
  year: 2020
  ident: CR29
  article-title: Bacterial nanocellulose membranes loaded with vitamin B-based ionic liquids for dermal care applications
  publication-title: J Mol Liq
  doi: 10.1016/j.molliq.2020.112547
– volume: 237
  start-page: 124436
  year: 2019
  ident: CR118
  article-title: Phytotoxicity of ionic liquids
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2019.124436
– volume: 11
  start-page: 492
  year: 2009
  ident: CR28
  article-title: Antibiofilm activities of 1-alkyl-3-methylimidazolium chloride ionic liquids
  publication-title: Green Chem
  doi: 10.1039/b821842k
– volume: 202
  start-page: 110902
  year: 2020
  ident: CR75
  article-title: Renal injury and hepatic effects from the methylimidazolium ionic liquid M8OI in mouse
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2020.110902
– volume: 19
  start-page: 4643
  year: 2009
  end-page: 4646
  ident: CR72
  article-title: Study on the potential anti-cancer activity of phosphonium and ammonium-based ionic liquids
  publication-title: Bioorg Med Chem Lett
  doi: 10.1016/j.bmcl.2009.06.086
– volume: 20
  start-page: 581
  year: 2010
  end-page: 585
  ident: CR101
  article-title: A profile of the in vitro anti-tumor activity of imidazolium-based ionic liquids
  publication-title: Bioorg Med Chem Lett
  doi: 10.1016/j.bmcl.2009.11.085
– volume: 154
  start-page: 335
  year: 2012
  end-page: 352
  ident: CR146
  article-title: Protic pharmaceutical ionic liquids and solids: aspects of protonics
  publication-title: Faraday Discuss
  doi: 10.1039/C1FD00071C
– volume: 68
  start-page: 171
  year: 2017
  end-page: 179
  ident: CR26
  article-title: Toxicity mechanisms of ionic liquids
  publication-title: Arch Ind Hyg Toxicol
  doi: 10.1515/aiht-2017-68-2979
– volume: 31
  start-page: 810
  year: 2012
  end-page: 816
  ident: CR115
  article-title: Diphosphonium ionic liquids as broad-spectrum anti-microbial agents
  publication-title: Cornea
  doi: 10.1097/ICO.0b013e31823f0a86
– volume: 116
  start-page: 25042
  year: 2019
  end-page: 25047
  ident: CR114
  article-title: Oral ionic liquid for the treatment of diet-induced obesity
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1914426116
– volume: 5
  start-page: 11935
  year: 2015
  ident: CR134
  article-title: Investigation of ion channel activities of gramicidin A in the presence of ionic liquids using model cell membranes
  publication-title: Sci Rep
  doi: 10.1038/srep11935
– volume: 571
  start-page: 245
  year: 2019
  end-page: 250
  ident: CR6
  article-title: Planar perovskite solar cells with long-term stability using ionic liquid additives
  publication-title: Nature
  doi: 10.1038/s41586-019-1357-2
– volume: 3
  start-page: 7
  year: 2018
  end-page: 25
  ident: CR1
  article-title: Ionic liquids for addressing unmet needs in healthcare: AGATEMOR et al
  publication-title: Bioeng Transl Med
  doi: 10.1002/btm2.10083
– volume: 8
  start-page: 621
  year: 2006
  ident: CR147
  article-title: Anion effects on the cytotoxicity of ionic liquids
  publication-title: Green Chem
  doi: 10.1039/b602161a
– volume: 91
  start-page: 1107
  year: 2013
  end-page: 1112
  ident: CR39
  article-title: Toxic effects of 1-decyl-3-methylimidazolium bromide ionic liquid on the antioxidant enzyme system and DNA in zebrafish (Danio rerio) livers
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2013.01.013
– volume: 113
  start-page: 1630
  year: 2016
  end-page: 1635
  ident: CR170
  article-title: Mode of action and resistance studies unveil new roles for tropodithietic acid as an anticancer agent and the γ-glutamyl cycle as a proton sink
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1518034113
– volume: 163
  start-page: 452
  year: 2016
  end-page: 460
  ident: CR181
  article-title: Time- and anion-dependent stimulation on triphosphopyridine nucleotide followed by antioxidant responses in Vibrio fischeri after exposure to 1-ethyl-3-methylimidazolium salts
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2016.08.061
– volume: 5
  start-page: 11151
  year: 2020
  end-page: 11159
  ident: CR185
  article-title: Magnetic ionic liquids as solvents for RNA extraction and preservation
  publication-title: ACS Omega
  doi: 10.1021/acsomega.0c01098
– volume: 517
  start-page: 455
  year: 2015
  end-page: 459
  ident: CR83
  article-title: A new antibiotic kills pathogens without detectable resistance
  publication-title: Nature
  doi: 10.1038/nature14098
– volume: 32
  start-page: 5403
  year: 2016
  end-page: 5411
  ident: CR176
  article-title: Molecular mechanism of ionic-liquid- induced membrane disruption: morphological changes to bilayers, multilayers, and vesicles
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.6b00768
– volume: 29
  start-page: 1038
  year: 2010
  end-page: 1054
  ident: CR48
  article-title: Impact of ionic liquids in environment and humans: an overview
  publication-title: Hum Exp Toxicol
  doi: 10.1177/0960327110371259
– volume: 18
  start-page: 197
  year: 2009
  end-page: 203
  ident: CR105
  article-title: Ionic liquids in soils: effects of different anion species of imidazolium based ionic liquids on wheat (Triticum aestivum) as affected by different clay minerals and clay concentrations
  publication-title: Ecotoxicology
  doi: 10.1007/s10646-008-0272-3
– volume: 46
  start-page: 1452
  year: 2010
  ident: CR109
  article-title: Ionic liquid-assisted transdermal delivery of sparingly soluble drugs
  publication-title: Chem Commun
  doi: 10.1039/b907462g
– volume: 92
  start-page: 112
  year: 2013
  end-page: 118
  ident: CR126
  article-title: In vitro cytotoxicity assessment of imidazolium ionic liquids: biological effects in fish Channel Catfish Ovary (CCO) cell line
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2013.03.002
– volume: 116
  start-page: 1017
  year: 2019
  end-page: 1026
  ident: CR184
  article-title: Rigidification of the Escherichia coli cytoplasm by the human antimicrobial peptide LL-37 revealed by superresolution fluorescence microscopy
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1814924116
– volume: 9
  start-page: 20191
  year: 2019
  ident: CR53
  article-title: Transdermal delivery of nobiletin using ionic liquids
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-56731-1
– volume: 9
  start-page: 251
  year: 2019
  ident: CR32
  article-title: Correlating lipid membrane permeabilities of imidazolium ionic liquids with their cytotoxicities on yeast, bacterial, and mammalian cells
  publication-title: Biomolecules
  doi: 10.3390/biom9060251
– volume: 10
  start-page: 8641
  year: 2014
  end-page: 8651
  ident: CR174
  article-title: Amphiphilic interactions of ionic liquids with lipid biomembranes: a molecular simulation study
  publication-title: Soft Matter
  doi: 10.1039/C4SM01528B
– volume: 565
  start-page: 219
  year: 2019
  end-page: 226
  ident: CR30
  article-title: In vivo biocompatibility, pharmacokinetics, antitumor efficacy, and hypersensitivity evaluation of ionic liquid-mediated paclitaxel formulations
  publication-title: Int J Pharm
  doi: 10.1016/j.ijpharm.2019.05.020
– volume: 430
  start-page: 4443
  year: 2018
  end-page: 4455
  ident: CR62
  article-title: Understanding protein mobility in bacteria by tracking single molecules
  publication-title: J Mol Biol
  doi: 10.1016/j.jmb.2018.05.002
– volume: 185
  start-page: 111832
  year: 2020
  ident: CR149
  article-title: Synthesis, characterization, and biological activity of a triphenylphosphonium-containing imidazolium salt against select bladder cancer cell lines
  publication-title: Eur J Med Chem
  doi: 10.1016/j.ejmech.2019.111832
– volume: 101
  start-page: 116
  year: 2014
  end-page: 123
  ident: CR35
  article-title: Imidiazolium based ionic liquids: effects of different anions and alkyl chains lengths on the barley seedlings
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2013.12.022
– volume: 50
  start-page: 1688
  year: 2014
  end-page: 1690
  ident: CR169
  article-title: Ionic liquids provide unique opportunities for oral drug delivery: structure optimization and in vivo evidence of utility
  publication-title: Chem Commun
  doi: 10.1039/C3CC48650H
– volume: 136
  start-page: 111069
  year: 2020
  ident: CR74
  article-title: The toxicity of the methylimidazolium ionic liquids, with a focus on M8OI and hepatic effects
  publication-title: Food Chem Toxicol
  doi: 10.1016/j.fct.2019.111069
– volume: 83
  start-page: 102
  year: 2012
  end-page: 107
  ident: CR78
  article-title: Apoptosis caused by imidazolium-based ionic liquids in PC12 cells
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2012.06.013
– volume: 111
  start-page: 13313
  year: 2014
  end-page: 13318
  ident: CR182
  article-title: Ionic liquids as a class of materials for transdermal delivery and pathogen neutralization
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1403995111
– volume: 120
  start-page: 342
  year: 2015
  end-page: 348
  ident: CR77
  article-title: Cytotoxicity, oxidative stress, and apoptosis in HepG2 cells induced by ionic liquid 1-methyl-3-octylimidazolium bromide
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2015.06.018
– volume: 77
  start-page: 313
  year: 2009
  end-page: 318
  ident: CR94
  article-title: The toxic effects of ionic liquids on the activities of acetylcholinesterase and cellulase in earthworms
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2009.07.026
– volume: 21
  start-page: 3936
  year: 2014
  end-page: 3945
  ident: CR86
  article-title: Effects of the ionic liquid 1-octyl-3-methylimidazolium hexafluorophosphate on the growth of wheat seedlings
  publication-title: Environ Sci Pollut Res
  doi: 10.1007/s11356-013-2348-8
– volume: 181
  start-page: 242
  year: 2013
  end-page: 249
  ident: CR85
  article-title: Phytotoxicity and oxidative stress effect of 1-octyl-3-methylimidazolium chloride ionic liquid on rice seedlings
  publication-title: Environ Pollut
  doi: 10.1016/j.envpol.2013.06.007
– volume: 4
  start-page: 11061
  year: 2019
  end-page: 11065
  ident: CR142
  article-title: Investigating the biological activity of imidazolium aurate salts
  publication-title: ChemistrySelect
  doi: 10.1002/slct.201903435
– volume: 99
  start-page: 2071
  year: 1999
  end-page: 2084
  ident: CR166
  article-title: Room-temperature ionic liquids Solvents for synthesis and catalysi
  publication-title: Chem Rev
  doi: 10.1021/cr980032t
– volume: 19
  start-page: 318
  year: 2017
  end-page: 329
  ident: CR113
  article-title: Hydrogen-bond dynamics at the bio–water interface in hydrated proteins: a molecular-dynamics study
  publication-title: Phys Chem Chem Phys
  doi: 10.1039/C6CP05601F
– volume: 72
  start-page: 1391
  year: 2000
  end-page: 1398
  ident: CR41
  article-title: Ionic liquids. Green solvents for the future
  publication-title: Pure Appl Chem
  doi: 10.1351/pac200072071391
– volume: 41
  start-page: 361
  year: 2012
  end-page: 367
  ident: CR100
  article-title: Bio-protective effects of homologous disaccharides on biological macromolecules
  publication-title: Eur Biophys J
  doi: 10.1007/s00249-011-0760-x
– volume: 116
  start-page: 26516
  year: 2019
  end-page: 26522
  ident: CR112
  article-title: The antimicrobial peptide ZY4 combats multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii infection
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1909585117
– volume: 73
  start-page: 1456
  year: 2010
  end-page: 1464
  ident: CR136
  article-title: Introduction of oxygenated side chain into imidazolium ionic liquids: evaluation of the effects at different biological organization levels
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2010.07.020
– volume: 113
  start-page: E7077
  year: 2016
  end-page: E7086
  ident: CR111
  article-title: Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1611173113
– volume: 5
  start-page: 1404
  year: 2014
  end-page: 1409
  ident: CR102
  article-title: Imidazolium-derived ionic salts induce inhibition of cancerous cell growth through apoptosis
  publication-title: Med Chem Commun
  doi: 10.1039/C4MD00161C
– volume: 27
  start-page: 330
  year: 2013
  end-page: 336
  ident: CR60
  article-title: Responses of the antioxidant system in QGY-7701 cells to the cytotoxicity and apoptosis induced by 1-octyl-3-methylimidazolium chloride: antioxidant system in Qgy-7701 cells
  publication-title: J Biochem Mol Toxicol
  doi: 10.1002/jbt.21495
– volume: 55
  start-page: 2161
  year: 2016
  end-page: 2166
  ident: CR63
  article-title: Direct observation of self-organized water-containing structures in the liquid phase and their influence on 5-(hydroxymethyl)furfural formation in ionic liquids
  publication-title: Angew Chem Int Ed
  doi: 10.1002/anie.201510090
– volume: 1804
  start-page: 49
  year: 2010
  end-page: 55
  ident: CR99
  article-title: Motion characterization by self-distribution–function procedure
  publication-title: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  doi: 10.1016/j.bbapap.2009.09.017
– volume: 72
  start-page: 1798
  year: 2009
  end-page: 1804
  ident: CR179
  article-title: Effects of the 1-alkyl-3-methylimidazolium bromide ionic liquids on the antioxidant defense system of Daphnia magna
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2009.05.002
– volume: 33
  start-page: 1333
  year: 2017
  end-page: 1342
  ident: CR40
  article-title: Imidazolium salts mimicking the structure of natural lipids exploit remarkable properties forming lamellar phases and giant vesicles
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.6b03182
– volume: 113
  start-page: 12150
  year: 2016
  end-page: 12155
  ident: CR103
  article-title: Context-specific inhibition of translation by ribosomal antibiotics targeting the peptidyl transferase center
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1613055113
– volume: 18
  start-page: 5640
  year: 2008
  end-page: 5642
  ident: CR67
  article-title: Synthesis of nucleoside-based antiviral drugs in ionic liquids
  publication-title: Bioorg Med Chem Lett
  doi: 10.1016/j.bmcl.2008.08.090
– volume: 9
  start-page: 19189
  year: 2019
  end-page: 19196
  ident: CR160
  article-title: Correlation between lipophilicity of newly synthesized ionic liquids and selected Fusarium genus growth rate
  publication-title: RSC Adv
  doi: 10.1039/C9RA02521A
– volume: 14
  start-page: 3669
  year: 2017
  end-page: 3683
  ident: CR135
  article-title: Ionic liquid forms of weakly acidic drugs in oral lipid formulations: preparation, characterization, in vitro digestion, and in vivo absorption studies
  publication-title: Mol Pharm
  doi: 10.1021/acs.molpharmaceut.7b00442
– volume: 116
  start-page: 26516
  year: 2019
  ident: 754_CR112
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1909585117
– volume: 26
  start-page: 1087
  year: 2012
  ident: 754_CR79
  publication-title: Toxicol in Vitro
  doi: 10.1016/j.tiv.2012.07.006
– volume: 113
  start-page: 1630
  year: 2016
  ident: 754_CR170
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1518034113
– volume: 201
  start-page: 59
  year: 2016
  ident: 754_CR65
  publication-title: Chem Phys Lipids
  doi: 10.1016/j.chemphyslip.2016.11.003
– volume: 10
  start-page: 8641
  year: 2014
  ident: 754_CR174
  publication-title: Soft Matter
  doi: 10.1039/C4SM01528B
– volume: 142
  start-page: 124706
  year: 2015
  ident: 754_CR14
  publication-title: J Chem Phys
  doi: 10.1063/1.4915918
– volume: 5
  start-page: 1404
  year: 2014
  ident: 754_CR102
  publication-title: Med Chem Commun
  doi: 10.1039/C4MD00161C
– volume: 10
  start-page: 709
  year: 2018
  ident: 754_CR21
  publication-title: Biophys Rev
  doi: 10.1007/s12551-017-0390-3
– volume: 118
  start-page: 2471
  year: 2014
  ident: 754_CR16
  publication-title: J Phys Chem
  doi: 10.1021/jp412281n
– volume: 311–312
  start-page: 162
  year: 2019
  ident: 754_CR125
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2019.08.029
– volume: 7
  start-page: 22927
  year: 2017
  ident: 754_CR116
  publication-title: RSC Adv
  doi: 10.1039/C7RA01520H
– volume: 32
  start-page: 12579
  year: 2016
  ident: 754_CR163
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.6b02496
– volume: 233
  start-page: 452
  year: 2017
  ident: 754_CR50
  publication-title: J Mol Liq
  doi: 10.1016/j.molliq.2017.02.078
– volume: 18
  start-page: 197
  year: 2009
  ident: 754_CR105
  publication-title: Ecotoxicology
  doi: 10.1007/s10646-008-0272-3
– volume: 33
  start-page: 1066
  year: 2017
  ident: 754_CR171
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.6b04359
– volume: 112
  start-page: E7073
  year: 2015
  ident: 754_CR47
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1521988112
– volume: 21
  start-page: 3936
  year: 2014
  ident: 754_CR86
  publication-title: Environ Sci Pollut Res
  doi: 10.1007/s11356-013-2348-8
– volume: 40
  start-page: 1383
  year: 2011
  ident: 754_CR119
  publication-title: Chem Soc Rev
  doi: 10.1039/C004968A
– volume: 41
  start-page: 361
  year: 2012
  ident: 754_CR100
  publication-title: Eur Biophys J
  doi: 10.1007/s00249-011-0760-x
– volume: 320
  start-page: 408
  year: 2016
  ident: 754_CR158
  publication-title: J Hazard Mater
  doi: 10.1016/j.jhazmat.2016.08.056
– volume: 113
  start-page: 978
  year: 2016
  ident: 754_CR55
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1517541113
– volume: 185
  start-page: 111832
  year: 2020
  ident: 754_CR149
  publication-title: Eur J Med Chem
  doi: 10.1016/j.ejmech.2019.111832
– volume: 1
  start-page: 34
  year: 2020
  ident: 754_CR19
  publication-title: Commun Mater
  doi: 10.1038/s43246-020-0035-0
– volume: 10
  start-page: 735
  year: 2018
  ident: 754_CR164
  publication-title: Biophys Rev
  doi: 10.1007/s12551-017-0388-x
– volume: 5
  start-page: 527
  year: 2014
  ident: 754_CR104
  publication-title: Annu Rev Chem Biomol Eng
  doi: 10.1146/annurev-chembioeng-060713-040024
– volume: 19
  start-page: 318
  year: 2017
  ident: 754_CR113
  publication-title: Phys Chem Chem Phys
  doi: 10.1039/C6CP05601F
– volume: 46
  start-page: 1452
  year: 2010
  ident: 754_CR109
  publication-title: Chem Commun
  doi: 10.1039/b907462g
– volume: 24
  start-page: 1882
  year: 2011
  ident: 754_CR70
  publication-title: Chem Res Toxicol
  doi: 10.1021/tx200228c
– volume: 145
  start-page: 269
  year: 2016
  ident: 754_CR90
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2015.11.055
– volume: 101
  start-page: 116
  year: 2014
  ident: 754_CR35
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2013.12.022
– volume: 348
  start-page: 1
  year: 2018
  ident: 754_CR172
  publication-title: J Hazard Mater
  doi: 10.1016/j.jhazmat.2018.01.028
– volume: 1804
  start-page: 49
  year: 2010
  ident: 754_CR99
  publication-title: Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  doi: 10.1016/j.bbapap.2009.09.017
– volume: 571
  start-page: 245
  year: 2019
  ident: 754_CR6
  publication-title: Nature
  doi: 10.1038/s41586-019-1357-2
– volume: 125
  start-page: 237
  year: 2017
  ident: 754_CR159
  publication-title: Water Res
  doi: 10.1016/j.watres.2017.08.046
– volume: 163
  start-page: 452
  year: 2016
  ident: 754_CR181
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2016.08.061
– volume: 72
  start-page: 552
  year: 2009
  ident: 754_CR80
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2007.11.002
– volume: 73
  start-page: 1046
  year: 2010
  ident: 754_CR93
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2010.01.017
– volume: 99
  start-page: 2071
  year: 1999
  ident: 754_CR166
  publication-title: Chem Rev
  doi: 10.1021/cr980032t
– volume: 19
  start-page: 790
  year: 2018
  ident: 754_CR144
  publication-title: IJMS
  doi: 10.3390/ijms19030790
– volume: 19
  start-page: 4643
  year: 2009
  ident: 754_CR72
  publication-title: Bioorg Med Chem Lett
  doi: 10.1016/j.bmcl.2009.06.086
– volume: 5
  start-page: 11935
  year: 2015
  ident: 754_CR134
  publication-title: Sci Rep
  doi: 10.1038/srep11935
– volume: 8
  start-page: 621
  year: 2006
  ident: 754_CR147
  publication-title: Green Chem
  doi: 10.1039/b602161a
– volume: 73
  start-page: 1465
  year: 2010
  ident: 754_CR95
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2009.10.004
– volume: 88
  start-page: 273
  year: 2006
  ident: 754_CR128
  publication-title: Toxicol Environ Chem
  doi: 10.1080/02772240600589505
– volume: 286
  start-page: 137
  year: 2018
  ident: 754_CR154
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2018.07.029
– volume: 3
  start-page: 7
  year: 2018
  ident: 754_CR1
  publication-title: Bioeng Transl Med
  doi: 10.1002/btm2.10083
– volume: 13
  start-page: 2794
  year: 2011
  ident: 754_CR107
  publication-title: Green Chem
  doi: 10.1039/c0gc00813c
– volume: 297
  start-page: 111751
  year: 2020
  ident: 754_CR44
  publication-title: J Mol Liq
  doi: 10.1016/j.molliq.2019.111751
– volume: 4
  start-page: 152
  year: 2015
  ident: 754_CR45
  publication-title: Toxicol Res
  doi: 10.1039/C4TX00079J
– volume: 9
  start-page: 1191
  year: 2007
  ident: 754_CR165
  publication-title: Green Chem
  doi: 10.1039/b704503d
– volume: 882
  start-page: 140
  year: 2008
  ident: 754_CR98
  publication-title: J Mol Struct
  doi: 10.1016/j.molstruc.2007.09.022
– ident: 754_CR117
  doi: 10.1002/chem.202003466
– volume: 237
  start-page: 124436
  year: 2019
  ident: 754_CR118
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2019.124436
– volume: 33
  start-page: 1333
  year: 2017
  ident: 754_CR40
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.6b03182
– volume: 34
  start-page: 12452
  year: 2018
  ident: 754_CR49
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.8b01554
– volume: 15
  start-page: e0229745
  year: 2020
  ident: 754_CR177
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0229745
– volume: 1
  start-page: 33
  year: 2012
  ident: 754_CR4
  publication-title: ChemistryOpen
  doi: 10.1002/open.201100003
– volume: 430
  start-page: 4443
  year: 2018
  ident: 754_CR62
  publication-title: J Mol Biol
  doi: 10.1016/j.jmb.2018.05.002
– volume: 139
  start-page: 1399
  year: 2003
  ident: 754_CR106
  publication-title: Br J Pharmacol
  doi: 10.1038/sj.bjp.0705374
– volume: 8
  start-page: 423
  year: 2010
  ident: 754_CR64
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro2333
– volume: 29
  start-page: 1038
  year: 2010
  ident: 754_CR48
  publication-title: Hum Exp Toxicol
  doi: 10.1177/0960327110371259
– volume: 4
  start-page: 392
  year: 2016
  ident: 754_CR13
  publication-title: ACS Sustain Chem Eng
  doi: 10.1021/acssuschemeng.5b01385
– volume: 2
  start-page: 143
  year: 2011
  ident: 754_CR97
  publication-title: Med Chem Commun
  doi: 10.1039/C0MD00201A
– volume: 181
  start-page: 242
  year: 2013
  ident: 754_CR85
  publication-title: Environ Pollut
  doi: 10.1016/j.envpol.2013.06.007
– volume: 10
  start-page: 721
  year: 2018
  ident: 754_CR139
  publication-title: Biophys Rev
  doi: 10.1007/s12551-018-0410-y
– volume: 10
  start-page: 1213
  year: 2008
  ident: 754_CR7
  publication-title: Green Chem
  doi: 10.1039/b807019a
– volume: 9
  start-page: 19189
  year: 2019
  ident: 754_CR160
  publication-title: RSC Adv
  doi: 10.1039/C9RA02521A
– volume: 5
  start-page: 11151
  year: 2020
  ident: 754_CR185
  publication-title: ACS Omega
  doi: 10.1021/acsomega.0c01098
– volume: 565
  start-page: 219
  year: 2019
  ident: 754_CR30
  publication-title: Int J Pharm
  doi: 10.1016/j.ijpharm.2019.05.020
– volume: 22
  start-page: 9775
  year: 2020
  ident: 754_CR24
  publication-title: Phys Chem Chem Phys
  doi: 10.1039/D0CP00801J
– volume: 302
  start-page: 112547
  year: 2020
  ident: 754_CR29
  publication-title: J Mol Liq
  doi: 10.1016/j.molliq.2020.112547
– volume: 105
  start-page: 425
  year: 2008
  ident: 754_CR121
  publication-title: J Biosci Bioeng
  doi: 10.1263/jbb.105.425
– volume: 52
  start-page: 1
  year: 2018
  ident: 754_CR161
  publication-title: Toxicol in Vitro
  doi: 10.1016/j.tiv.2018.05.013
– volume: 307
  start-page: 73
  year: 2016
  ident: 754_CR180
  publication-title: J Hazard Mater
  doi: 10.1016/j.jhazmat.2015.12.028
– volume: 7
  start-page: 336
  year: 2014
  ident: 754_CR42
  publication-title: ChemSusChem
  doi: 10.1002/cssc.201300459
– volume: 323
  start-page: 475
  year: 2020
  ident: 754_CR37
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2020.04.038
– volume: 13
  start-page: 42
  year: 2015
  ident: 754_CR22
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro3380
– volume: 32
  start-page: 5403
  year: 2016
  ident: 754_CR176
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.6b00768
– volume: 551
  start-page: 227
  year: 2018
  ident: 754_CR12
  publication-title: Phys B Condens Matter
  doi: 10.1016/j.physb.2018.02.043
– volume: 24
  start-page: 2669
  year: 2018
  ident: 754_CR133
  publication-title: Chem Eur J
  doi: 10.1002/chem.201704924
– volume: 111
  start-page: E1409
  year: 2014
  ident: 754_CR168
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1319900111
– volume: 9
  start-page: 251
  year: 2019
  ident: 754_CR32
  publication-title: Biomolecules
  doi: 10.3390/biom9060251
– volume: 33
  start-page: 1295
  year: 2017
  ident: 754_CR20
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.6b03192
– volume: 39
  start-page: 600
  year: 2010
  ident: 754_CR31
  publication-title: Chem Soc Rev
  doi: 10.1039/b817717c
– volume: 5
  start-page: 18444
  year: 2015
  ident: 754_CR84
  publication-title: Sci Rep
  doi: 10.1038/srep18444
– volume: 202
  start-page: 110902
  year: 2020
  ident: 754_CR75
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2020.110902
– volume: 33
  start-page: 91
  year: 2014
  ident: 754_CR59
  publication-title: Toxin Rev
  doi: 10.3109/15569543.2013.867885
– volume: 93
  start-page: 2488
  year: 2013
  ident: 754_CR76
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2013.08.092
– volume: 517
  start-page: 455
  year: 2015
  ident: 754_CR83
  publication-title: Nature
  doi: 10.1038/nature14098
– volume: 116
  start-page: 25042
  year: 2019
  ident: 754_CR114
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1914426116
– volume: 11
  start-page: 1455
  year: 2020
  ident: 754_CR51
  publication-title: Nat Commun
  doi: 10.1038/s41467-020-15257-1
– volume: 6
  start-page: 19889
  year: 2016
  ident: 754_CR175
  publication-title: Sci Rep
  doi: 10.1038/srep19889
– volume: 21
  start-page: 253
  year: 2012
  ident: 754_CR82
  publication-title: Ecotoxicology
  doi: 10.1007/s10646-011-0785-z
– volume: 92
  start-page: 112
  year: 2013
  ident: 754_CR126
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2013.03.002
– volume: 1862
  start-page: 183103
  year: 2020
  ident: 754_CR5
  publication-title: Biochim Biophys Acta Biomembr
  doi: 10.1016/j.bbamem.2019.183103
– volume: 112
  start-page: 8558
  year: 2008
  ident: 754_CR46
  publication-title: J Phys Chem B
  doi: 10.1021/jp7116592
– volume: 111
  start-page: 3508
  year: 2011
  ident: 754_CR52
  publication-title: Chem Rev
  doi: 10.1021/cr1003248
– volume: 2
  start-page: 2331
  year: 2011
  ident: 754_CR108
  publication-title: J Phys Chem Lett
  doi: 10.1021/jz201006b
– volume: 120
  start-page: 342
  year: 2015
  ident: 754_CR77
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2015.06.018
– volume: 31
  start-page: 810
  year: 2012
  ident: 754_CR115
  publication-title: Cornea
  doi: 10.1097/ICO.0b013e31823f0a86
– volume: 10
  start-page: 853
  year: 2018
  ident: 754_CR152
  publication-title: Biophys Rev
  doi: 10.1007/s12551-018-0421-8
– volume: 10
  start-page: 751
  year: 2018
  ident: 754_CR132
  publication-title: Biophys Rev
  doi: 10.1007/s12551-018-0424-5
– volume: 622–623
  start-page: 1572
  year: 2018
  ident: 754_CR91
  publication-title: Sci Total Environ
  doi: 10.1016/j.scitotenv.2017.10.021
– volume: 122
  start-page: 83
  year: 2015
  ident: 754_CR88
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2015.07.010
– volume: 264
  start-page: 246
  year: 2014
  ident: 754_CR183
  publication-title: J Hazard Mater
  doi: 10.1016/j.jhazmat.2013.11.003
– volume: 83
  start-page: 102
  year: 2012
  ident: 754_CR78
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2012.06.013
– ident: 754_CR151
  doi: 10.1039/b316491h
– volume: 11
  start-page: 492
  year: 2009
  ident: 754_CR28
  publication-title: Green Chem
  doi: 10.1039/b821842k
– volume: 115
  start-page: 7296
  year: 2018
  ident: 754_CR8
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1722338115
– volume: 167
  start-page: 114
  year: 2017
  ident: 754_CR123
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2016.09.140
– volume: 10
  start-page: 687
  year: 2018
  ident: 754_CR15
  publication-title: Biophys Rev
  doi: 10.1007/s12551-018-0426-3
– volume: 46
  start-page: 194
  year: 2018
  ident: 754_CR57
  publication-title: Toxicol in Vitro
  doi: 10.1016/j.tiv.2017.09.025
– volume: 27
  start-page: 330
  year: 2013
  ident: 754_CR60
  publication-title: J Biochem Mol Toxicol
  doi: 10.1002/jbt.21495
– volume: 19
  start-page: 311
  year: 2020
  ident: 754_CR110
  publication-title: Nat Rev Drug Discov
  doi: 10.1038/s41573-019-0058-8
– volume: 10
  start-page: 931
  year: 2018
  ident: 754_CR156
  publication-title: Biophys Rev
  doi: 10.1007/s12551-018-0422-7
– volume: 34
  start-page: 9579
  year: 2018
  ident: 754_CR11
  publication-title: Langmuir
  doi: 10.1021/acs.langmuir.7b04361
– volume: 285
  start-page: 27
  year: 2015
  ident: 754_CR89
  publication-title: J Hazard Mater
  doi: 10.1016/j.jhazmat.2014.11.028
– volume: 14
  start-page: 3669
  year: 2017
  ident: 754_CR135
  publication-title: Mol Pharm
  doi: 10.1021/acs.molpharmaceut.7b00442
– volume: 113
  start-page: E7077
  year: 2016
  ident: 754_CR111
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1611173113
– volume: 150
  start-page: 266
  year: 2016
  ident: 754_CR54
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2016.02.029
– volume: 10
  start-page: 691
  year: 2018
  ident: 754_CR167
  publication-title: Biophys Rev
  doi: 10.1007/s12551-018-0419-2
– volume: 72
  start-page: 1798
  year: 2009
  ident: 754_CR179
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2009.05.002
– volume: 467
  start-page: 1033
  year: 2015
  ident: 754_CR162
  publication-title: Biochem Biophys Res Commun
  doi: 10.1016/j.bbrc.2015.10.015
– volume: 68
  start-page: 171
  year: 2017
  ident: 754_CR26
  publication-title: Arch Ind Hyg Toxicol
  doi: 10.1515/aiht-2017-68-2979
– volume: 265
  start-page: 428
  year: 2018
  ident: 754_CR131
  publication-title: J Mol Liq
  doi: 10.1016/j.molliq.2018.06.045
– volume: 55
  start-page: 2161
  year: 2016
  ident: 754_CR63
  publication-title: Angew Chem Int Ed
  doi: 10.1002/anie.201510090
– volume: 10
  start-page: 3517
  year: 2019
  ident: 754_CR96
  publication-title: Nat Commun
  doi: 10.1038/s41467-019-11503-3
– volume: 3
  start-page: 2000041
  year: 2020
  ident: 754_CR155
  publication-title: Adv Therap
  doi: 10.1002/adtp.202000041
– volume: 77
  start-page: 313
  year: 2009
  ident: 754_CR94
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2009.07.026
– volume: 4
  start-page: 2370
  year: 2018
  ident: 754_CR58
  publication-title: ACS Biomater Sci Eng
  doi: 10.1021/acsbiomaterials.8b00486
– volume: 113
  start-page: 12150
  year: 2016
  ident: 754_CR103
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1613055113
– volume: 69
  start-page: 611
  year: 2017
  ident: 754_CR69
  publication-title: Int J Biol Macromol
  doi: 10.1016/j.ijbiomac.2016.12.005
– volume: 12
  start-page: 593
  year: 2010
  ident: 754_CR92
  publication-title: Green Chem
  doi: 10.1039/b921805j
– volume: 73
  start-page: 1456
  year: 2010
  ident: 754_CR136
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2010.07.020
– volume: 4
  start-page: 11061
  year: 2019
  ident: 754_CR142
  publication-title: ChemistrySelect
  doi: 10.1002/slct.201903435
– volume: 10
  start-page: 836
  year: 2008
  ident: 754_CR33
  publication-title: Green Chem
  doi: 10.1039/b807214k
– volume: 393
  start-page: 983
  year: 2009
  ident: 754_CR150
  publication-title: Anal Bioanal Chem
  doi: 10.1007/s00216-008-2523-9
– volume: 136
  start-page: 111069
  year: 2020
  ident: 754_CR74
  publication-title: Food Chem Toxicol
  doi: 10.1016/j.fct.2019.111069
– volume: 31
  start-page: 1429
  year: 2007
  ident: 754_CR56
  publication-title: New J Chem
  doi: 10.1039/b706677p
– volume: 58
  start-page: 396
  year: 2004
  ident: 754_CR127
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/S0147-6513(03)00105-2
– volume: 18
  start-page: 5640
  year: 2008
  ident: 754_CR67
  publication-title: Bioorg Med Chem Lett
  doi: 10.1016/j.bmcl.2008.08.090
– volume: 10
  start-page: 847
  year: 2018
  ident: 754_CR122
  publication-title: Biophys Rev
  doi: 10.1007/s12551-018-0425-4
– volume: 9
  start-page: 20191
  year: 2019
  ident: 754_CR53
  publication-title: Sci Rep
  doi: 10.1038/s41598-019-56731-1
– volume: 71
  start-page: 903
  year: 2008
  ident: 754_CR178
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2008.02.022
– volume: 4
  start-page: 5682
  year: 2019
  ident: 754_CR141
  publication-title: ACS Omega
  doi: 10.1021/acsomega.8b03691
– volume: 31
  start-page: 1901103
  year: 2019
  ident: 754_CR153
  publication-title: Adv Mater
  doi: 10.1002/adma.201901103
– volume: 154
  start-page: 335
  year: 2012
  ident: 754_CR146
  publication-title: Faraday Discuss
  doi: 10.1039/C1FD00071C
– volume: 71
  start-page: 157
  year: 2008
  ident: 754_CR145
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2007.08.011
– volume: 9
  start-page: 309
  year: 2017
  ident: 754_CR10
  publication-title: Biophys Rev
  doi: 10.1007/s12551-017-0279-1
– volume: 20
  start-page: 581
  year: 2010
  ident: 754_CR101
  publication-title: Bioorg Med Chem Lett
  doi: 10.1016/j.bmcl.2009.11.085
– volume: 91
  start-page: 1107
  year: 2013
  ident: 754_CR39
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2013.01.013
– volume: 240
  start-page: 124919
  year: 2020
  ident: 754_CR173
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2019.124919
– volume: 107
  start-page: 12281
  year: 2010
  ident: 754_CR148
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.1005485107
– volume: 50
  start-page: 1688
  year: 2014
  ident: 754_CR169
  publication-title: Chem Commun
  doi: 10.1039/C3CC48650H
– volume: 36
  start-page: 56
  year: 2012
  ident: 754_CR120
  publication-title: New J Chem
  doi: 10.1039/C1NJ20470J
– volume: 176
  start-page: 119
  year: 2000
  ident: 754_CR137
  publication-title: J Membr Biol
  doi: 10.1007/s00232001078
– volume: 194
  start-page: 110392
  year: 2020
  ident: 754_CR36
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2020.110392
– volume: 10
  start-page: 2321
  year: 2017
  ident: 754_CR34
  publication-title: ChemSusChem
  doi: 10.1002/cssc.201700261
– volume: 116
  start-page: 1017
  year: 2019
  ident: 754_CR184
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1814924116
– volume: 12
  start-page: 109
  year: 2016
  ident: 754_CR130
  publication-title: Nat Chem Biol
  doi: 10.1038/nchembio.1986
– volume: 78
  start-page: 853
  year: 2010
  ident: 754_CR81
  publication-title: Chemosphere
  doi: 10.1016/j.chemosphere.2009.11.047
– volume: 9
  start-page: 481
  year: 2007
  ident: 754_CR23
  publication-title: Green Chem
  doi: 10.1039/b615406a
– volume: 117
  start-page: 7132
  year: 2017
  ident: 754_CR43
  publication-title: Chem Rev
  doi: 10.1021/acs.chemrev.6b00562
– volume: 24
  start-page: 388
  year: 2009
  ident: 754_CR71
  publication-title: Environ Toxicol
  doi: 10.1002/tox.20443
– volume: 322
  start-page: 602
  year: 2020
  ident: 754_CR140
  publication-title: J Control Release
  doi: 10.1016/j.jconrel.2020.03.018
– volume: 7
  start-page: 185
  year: 2005
  ident: 754_CR38
  publication-title: Green Chem
  doi: 10.1039/b419172b
– volume: 250
  start-page: 567
  year: 2019
  ident: 754_CR157
  publication-title: Environ Pollut
  doi: 10.1016/j.envpol.2019.04.043
– volume: 72
  start-page: 1391
  year: 2000
  ident: 754_CR41
  publication-title: Pure Appl Chem
  doi: 10.1351/pac200072071391
– volume: 57
  start-page: 266
  year: 2010
  ident: 754_CR61
  publication-title: Regul Toxicol Pharmacol
  doi: 10.1016/j.yrtph.2010.03.006
– volume: 67
  start-page: 430
  year: 2007
  ident: 754_CR129
  publication-title: Ecotoxicol Environ Saf
  doi: 10.1016/j.ecoenv.2006.08.008
– volume: 3
  start-page: 238
  year: 2005
  ident: 754_CR25
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro1098
– volume: 22
  start-page: 11975
  year: 2015
  ident: 754_CR66
  publication-title: Environ Sci Pollut Res
  doi: 10.1007/s11356-015-4794-y
– volume: 169
  start-page: 179
  year: 2015
  ident: 754_CR87
  publication-title: Aquat Toxicol
  doi: 10.1016/j.aquatox.2015.10.024
– volume: 3
  start-page: 55
  year: 2020
  ident: 754_CR27
  publication-title: Commun Chem
  doi: 10.1038/s42004-020-0302-5
– volume: 11
  start-page: 7327
  year: 2020
  ident: 754_CR73
  publication-title: J Phys Chem Lett
  doi: 10.1021/acs.jpclett.0c02149
– volume: 8
  start-page: 238
  year: 2006
  ident: 754_CR124
  publication-title: Green Chem
  doi: 10.1039/B511554J
– volume: 104
  start-page: 7893
  year: 2007
  ident: 754_CR3
  publication-title: Proc Natl Acad Sci
  doi: 10.1073/pnas.0702439104
– volume: 8
  start-page: 1939
  year: 2017
  ident: 754_CR9
  publication-title: Nat Commun
  doi: 10.1038/s41467-017-02118-7
– volume: 49
  start-page: 2158
  year: 2014
  ident: 754_CR68
  publication-title: Process Biochem
  doi: 10.1016/j.procbio.2014.09.014
– volume: 118
  start-page: 12192
  year: 2014
  ident: 754_CR17
  publication-title: J Phys Chem B
  doi: 10.1021/jp507631h
– volume: 24
  start-page: 1759
  year: 2005
  ident: 754_CR18
  publication-title: Environ Toxicol Chem
  doi: 10.1897/04-614R.1
– volume: 15
  start-page: 1900073
  year: 2020
  ident: 754_CR143
  publication-title: Biotechnol J
  doi: 10.1002/biot.201900073
– volume: 20
  start-page: 2865
  year: 2019
  ident: 754_CR2
  publication-title: IJMS
  doi: 10.3390/ijms20122865
– volume: 13
  start-page: 8969
  year: 2017
  ident: 754_CR138
  publication-title: Soft Matter
  doi: 10.1039/C7SM01799E
– ident: 754_CR186
  doi: 10.1016/j.watres.2009.09.030
– volume: 111
  start-page: 13313
  year: 2014
  ident: 754_CR182
  publication-title: Proc Natl Acad Sci U S A
  doi: 10.1073/pnas.1403995111
SSID ssj0064285
Score 2.5002232
SecondaryResourceType review_article
Snippet Ionic liquids (ILs) are a relatively new class of organic electrolytes composed of an organic cation and either an organic or inorganic anion, whose melting...
SourceID pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 1187
SubjectTerms Biochemistry
Biological and Medical Physics
Biological Techniques
Biomedical and Life Sciences
Biomolecules
Biophysics
Cell Biology
Cell membranes
Chloroplasts
DNA fragmentation
Electrolytic cells
Ionic liquids
Life Sciences
Lipids
Melt temperature
Membrane Biology
Mitochondria
Nanotechnology
Nonaqueous electrolytes
Nuclear membranes
Reactive oxygen species
Review
Reviews
Room temperature
State-of-the-art reviews
Toxicity
Viscoelasticity
Title Mechanisms of action of ionic liquids on living cells: the state of the art
URI https://link.springer.com/article/10.1007/s12551-020-00754-w
https://www.ncbi.nlm.nih.gov/pubmed/32936423
https://www.proquest.com/docview/2473816574
https://www.proquest.com/docview/2443517294
https://pubmed.ncbi.nlm.nih.gov/PMC7575683
Volume 12
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3dS8MwED_cRPBF_HY6RwXftLA1aZr4NoZzKPrkQJ9Km6Q40E7txvC_964fG_MLfEvIJU0vl-R3yd0F4DTCbUB5hrkK9QmXk22N4m3rJkx6cYLzqW3IUfj2TgyG_PrBfyidwrLK2r26ksxX6oWzG6JfVH098oQOfO7OarDqo-5Ocj30utX6S4CaDBcpUpvrcb9dusr83MbydvQNY343lfxyX5pvQ_1N2Cjxo9MtBnwLVmy6DWvFi5IfO3Bza8mVd5S9ZM44cQqvBUrRsat2nkdv05HBohSTdJTg0MF9duEgDHRy3yKipQxK1C4M-5f3vYFbvpfgaq68mSt1O5KBNkJa1INUjFmhWOILSfdtjMVCYUokjMeJjHBnV1wbHmtptLFGBGwP6uk4tQfgMI3QMKZALkihdScS3HIrOyzAFrRhDehUbAt1GUyc3rR4DhdhkInVIbI6zFkdzhpwNq_zWoTS-JO6WY1GWE6rLPR4QBedfsAbcDIvxglBzIpSO54SDSJAhGUKafaLwZt_jiG4QfnA7gdLwzonoGDbyyXp6CkPuh0grhUSa55XArDo1u9_cfg_8iNY90g4c2PBJtQn71N7jKBnErdgtXv1eHPZglpP9Fq5xH8CO4b52A
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1bT8IwFG4UY_TFeBdFnYlvughr17W-GaJBuTxBwtuytV0kwaEOQvz3nrMLBFAT39r0dOtOT3e-Xs5XQq4DcAPS0dSWMJ-wGZ6tkaxq7IgKJ4xgPFU1Bgq3O7zRYy99t5_T5GAszNL-_V0CDtiFCa-D8c-ey-zpOtlgMFNGnvw6rxd_XYTReFwR-dlsh7nVPEDm52csOqEVZLl6QHJplzR1Pk-7ZCdHjdZD1s17ZM3E-2Qzu0fy64A02wYDeAfJW2KNIiuLVcAULrYqazj4mAw0FMWQxAUEC5frk3sLwJ-VRhShLGbAjg5J7-mxW2_Y-S0JtmLSmdpCVQPhKc2FgdmPDCHLJY1cLnCXjdKQS0jxiLIwEgH4c8mUZqESWmmjuUePSCkexeaEWFQBIAyRvgUklKoFnBlmRI168ASlaZnUCrX5KqcQx5sshv6c_BhV7YOq_VTV_rRMbmZ13jMCjT-lK0Vv-PlgSnyHebi96XqsTK5mxTAMUFlBbEYTlAHcB2BMgsxx1nmz11GANGAf0HxvoVtnAkixvVgSD15Tqm0P0CwXUPO2MIB5s37_itP_iV-SrUa33fJbz53mGdl20FDT44IVUhp_Tsw5wJ5xeJHa-zcGhvY5
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3dT8IwEG8Uo_HF-C2KOhPfdBHWrmt9MyhBEeKDJLwtW9tFEhwoEOJ_790-QERNfGvT69Zdr-uv7f2uhJwHMA1IR1NbwnrCZuhbI1nZ2BEVThjBeCprJAo3W7zeZg8dt_OFxZ94u-dHkimnAaM0xaOrgY6uZsQ3QMKwDHaQFe25zJ4skxVYqVTQqa_Kq_m_GME1OjFi1DbbYW45o838_Iz5qWkBby66TX47O02mpNom2ciwpHWTdv4WWTLxNllNb5f82CGNpkFab3f4OrT6kZUyGDCFW7DK6nXfxl0NRTEkcVvBwk384bUFkNBKeEYoixmwrl3Srt09V-t2dneCrZh0JrZQ5UB4SnNhYE0kQ8hySSOXCzx7ozTkElI8oiyMRACzvGRKs1AJrbTR3KN7pBD3Y3NALKoAJoYY1AUklKoEnBlmRIV68ASlaZFUcrX5Kgssjvdb9PxZSGRUtQ-q9hNV-5MiuZjWGaRhNf6ULuW94WdDbOg7zMNDT9djRXI2LYbBgcoKYtMfowygQYBoEmT2086bvo4C0AH7gOZ7c906FcDA2_MlcfclCcDtAcblAmpe5gYwa9bvX3H4P_FTsvZ0W_Mf71uNI7LuoJ0mPoQlUhi9j80xYKFReJKY-ye35P6A
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Mechanisms+of+action+of+ionic+liquids+on+living+cells%3A+the+state+of+the+art&rft.jtitle=Biophysical+reviews&rft.au=Kumari%2C+Pallavi&rft.au=Pillai%2C+Visakh+V.S.&rft.au=Benedetto%2C+Antonio&rft.date=2020-10-01&rft.pub=Springer+Berlin+Heidelberg&rft.issn=1867-2450&rft.eissn=1867-2469&rft.volume=12&rft.issue=5&rft.spage=1187&rft.epage=1215&rft_id=info:doi/10.1007%2Fs12551-020-00754-w&rft_id=info%3Apmid%2F32936423&rft.externalDocID=PMC7575683
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1867-2450&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1867-2450&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1867-2450&client=summon