Scalable deoxygenative alkynylation of alcohols via flow photochemistry

• Published in: Communications chemistry Vol. 7; no. 1; pp. 276 - 8
• Main Authors: Xu, Pin, Ma, Cong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.11.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 639/638/403/933; 639/638/439/890; 639/638/549/976; 639/638/77/890; Adducts; Alcohol; Alcohols; Alkynes; Biological activity; Biomolecules; Carbenes; Chemical synthesis; Chemistry; Chemistry and Materials Science; Chemistry/Food Science; Deoxygenation; Functional groups; Oxidation; Pharmaceuticals; Photochemistry; Production methods

Internal alkynes are often contained in bioactive pharmaceuticals and crucial intermediates in material sciences, yet their production methods are often limited and challenging, necessitating the development of more efficient and versatile synthetic routes. Here we report a method of deoxygenative a...