Narcolepsy, 2009 A(H1N1) pandemic influenza, and pandemic influenza vaccinations: What is known and unknown about the neurological disorder, the role for autoimmunity, and vaccine adjuvants

• Published in: Journal of autoimmunity Vol. 50; pp. 1 - 11
• Main Authors: Ahmed, S. Sohail, Schur, Peter H., MacDonald, Noni E., Steinman, Lawrence
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.05.2014; Elsevier
• Subjects: Adjuvants; Adjuvants, Immunologic - administration & dosage; Adjuvants, Immunologic - chemistry; Allergy and Immunology; alpha-Tocopherol - administration & dosage; alpha-Tocopherol - chemistry; alpha-Tocopherol - immunology; Antibodies, Viral - blood; Antigens, Viral - chemistry; Antigens, Viral - immunology; Autoimmune disease; Autoimmunity; Biological and medical sciences; Canada - epidemiology; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes; Drug Combinations; Europe - epidemiology; Fundamental and applied biological sciences. Psychology; Fundamental immunology; H1N1 infection; Human viral diseases; Humans; Infectious diseases; Influenza A Virus, H1N1 Subtype - immunology; Influenza A Virus, H1N1 Subtype - pathogenicity; Influenza Vaccines - adverse effects; Influenza Vaccines - biosynthesis; Influenza Vaccines - immunology; Influenza, Human - epidemiology; Influenza, Human - immunology; Influenza, Human - prevention & control; Medical sciences; Molecular mimicry; Narcolepsy; Narcolepsy - chemically induced; Narcolepsy - physiopathology; Nervous system (semeiology, syndromes); Neurology; Pandemics - prevention & control; Polysorbates - administration & dosage; Polysorbates - chemistry; Squalene - administration & dosage; Squalene - chemistry; Squalene - immunology; Vaccination - adverse effects; Vaccines; Viral diseases; Viral diseases of the respiratory system and ent viral diseases; Canada; Europe; Adjuvants; Autoimmune disease; Narcolepsy; Molecular mimicry; Vaccines; H1N1 infection; Autoimmunity; Immunopathology; Nervous system diseases; Respiratory disease; H1N1 influenza; Vaccination; Sleep disorder; Pandemic; Vaccine; Infection; Prevention; Immunology; Viral disease; Adjuvant; Neurological disorder

The vaccine safety surveillance system effectively detected a very rare adverse event, narcolepsy, in subjects receiving AS03-adjuvanted A(H1N1) pandemic vaccine made using the European inactivation/purification protocol. The reports of increased cases of narcolepsy in non-vaccinated subjects infect...