Resting-state functional magnetic resonance imaging study on cerebrovascular reactivity changes in the precuneus of Alzheimer’s disease and mild cognitive impairment patients

• Published in: Scientific reports Vol. 15; no. 1; pp. 363 - 12
• Main Authors: Tang, Xue, Wang, Luoyu, Feng, Qi, Hu, Hanjun, Zhu, Yidi, Liao, Zhengluan, Ding, Zhongxiang, Xu, Xiufang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.01.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308; 692/617; Aged; Alzheimer Disease - diagnostic imaging; Alzheimer Disease - physiopathology; Alzheimer's disease; Brain; Brain mapping; Brain Mapping - methods; Case-Control Studies; Cerebrovascular Circulation - physiology; cerebrovascular reactivity; Cognitive ability; Cognitive Dysfunction - diagnostic imaging; Cognitive Dysfunction - physiopathology; Correlation analysis; Cortex (parietal); Dementia disorders; Female; Functional magnetic resonance imaging; Humanities and Social Sciences; Humans; Hypercapnia; Image processing; Magnetic resonance imaging; Magnetic Resonance Imaging - methods; Male; Middle Aged; mild cognitive impairment; multidisciplinary; Neural networks; Neurodegenerative diseases; Neuroimaging; Parietal Lobe - diagnostic imaging; Parietal Lobe - physiopathology; Rest - physiology; resting-state functional magnetic resonance imaging; Science; Science (multidisciplinary); resting-state functional magnetic resonance imaging; mild cognitive impairment; cerebrovascular reactivity; Alzheimer’s disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by memory impairment and cognitive decline, ultimately culminating in dementia. This study aims to evaluate cerebrovascular reactivity (CVR) and functional connectivity (FC) in patients with AD and mild cognitive impa...