Defective germinal center selection results in persistence of self-reactive B cells from the primary to the secondary repertoire in Primary Antiphospholipid Syndrome - Dieudonné, Yannick; Lorenzetti, Raquel; Rottura, Julien; Janowska, Iga; Frenger, Quentin; Jacquel, Léa; Vollmer, Olivier; Carbone, Francesco; Chengsong, Zhu; Luka, Marine; Depauw, Sabine; Wadier, Nadège; et al. (Nature communications, 2024)
Keywords: 38/77; 38/91; 49/1; 49/31; 631/250/2152/2153/1291; 631/250/249/1313; 631/250/2502; 692/420/2780/2152/569/2495; Adult; Aged; Antibodies, Antiphospholipid - immunology; Antiphospholipid antibodies; Antiphospholipid syndrome; Antiphospholipid Syndrome - immunology; APRIL protein; Autoantibodies; Autoantibodies - immunology; Autoimmune diseases; B-cell receptor; B-Lymphocytes - immunology; Bone marrow; Cell immortalization; Cell survival; Clotting; Female; Gene sequencing; Germinal Center - immunology; Germinal centers; Humanities and Social Sciences; Humans; Immortalization; Immunological memory; Lymphocytes B; Male; Memory cells; Middle Aged; multidisciplinary; Myc protein; Peripheral blood; Receptors, Antigen, B-Cell - immunology; Receptors, Antigen, B-Cell - metabolism; Science; Science (multidisciplinary); Single-Cell Analysis; Therapeutic targets