Multidrug efflux transporter, AcrB—the pumping mechanism

• Published in: Current opinion in structural biology Vol. 18; no. 4; pp. 459 - 465
• Main Author: Murakami, Satoshi
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.08.2008
• Subjects: Catalysis; Crystallography, X-Ray; Escherichia coli; Ion Transport; Multidrug Resistance-Associated Proteins - chemistry; Multidrug Resistance-Associated Proteins - physiology; Protein Conformation; Protons

Resistance nodulation cell division (RND) transporters are one of the main causes of the bacterial multidrug resistance. They pump a wide range of antibiotics out of the cell by proton motive force. AcrB is the major RND transporter in Escherichia coli. Recently, the crystal structures of AcrB have...