Association between periodontal disease and schizophrenia: a bidirectional two-sample Mendelian randomization study

• Published in: Scientific reports Vol. 14; no. 1; pp. 17391 - 8
• Main Authors: Cao, Hongliang, Wu, Hao, Wang, Pengyu, Zhang, Haiyang, Wang, Song
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.07.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/477; 692/308; 692/499; 692/699; Bi-directional causal effects; Case-Control Studies; Finland - epidemiology; Genetic analysis; Genetic Predisposition to Disease; Genome-Wide Association Study; Gum disease; Humanities and Social Sciences; Humans; Mendelian randomization; Mendelian Randomization Analysis; Mental disorders; multidisciplinary; Observational studies; Periodontal disease; Periodontal diseases; Periodontal Diseases - epidemiology; Periodontal Diseases - genetics; Pleiotropy; Polymorphism, Single Nucleotide; Schizophrenia; Schizophrenia - genetics; Science; Science (multidisciplinary); Sensitivity analysis; Finland; Schizophrenia; Periodontal disease; Bi-directional causal effects; Mendelian randomization

The connection between periodontal disease (PD) and schizophrenia (SCZ) has been reported in observational studies, but it remains unclear. This research aims to examine the bidirectional causal impacts between PD and SCZ. The FinnGen consortium supplied summarized data on PD for 346,731 individuals...