Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells

• Published in: Biochemical journal Vol. 348 Pt 2; no. 2; pp. 425 - 432
• Main Authors: Lee, H C, Yin, P H, Lu, C Y, Chi, C W, Wei, Y H
• Format: Journal Article
• Language: English
• Published: England 01.06.2000
• Subjects: buthionine sulfoximine; Cell Cycle - drug effects; Cell Division - drug effects; Cell Line; Cell Survival - drug effects; DNA, Mitochondrial - drug effects; DNA, Mitochondrial - metabolism; Fibroblasts; genistein; Genistein - pharmacology; Humans; Hydrogen Peroxide - pharmacology; lovastatin; Lovastatin - pharmacology; Lung; mimosine; Mimosine - pharmacology; Mitochondria - drug effects; Mitochondria - physiology; Mitochondria - ultrastructure; Oxidative Stress - physiology; Rhodamine 123 - pharmacokinetics; Tetrazolium Salts - pharmacokinetics

Mitochondrial respiratory function is impaired in the target tissues of patients with mitochondrial diseases and declines with age in various human tissues. It is generally accepted that respiratory-chain defects result in enhanced production of reactive oxygen species and free radicals in mitochond...