Polymer grafted magnetic nanoparticles for delivery of anticancer drug at lower pH and elevated temperature

• Published in: Journal of colloid and interface science Vol. 467; pp. 70 - 80
• Main Authors: Dutta, Sujan, Parida, Sheetal, Maiti, Chiranjit, Banerjee, Rakesh, Mandal, Mahitosh, Dhara, Dibakar
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.04.2016
• Subjects: Antineoplastic Agents - administration & dosage; Antineoplastic Agents - pharmacology; Apoptosis; Apoptosis - drug effects; Block copolymer; Cancer; Cell Line; Cell Proliferation - drug effects; Copolymers; Doxorubicin; Drug Delivery Systems; Drugs; Grafting; Humans; Hydrogen-Ion Concentration; Iron oxide nanoparticles; Iron oxides; Magnetite Nanoparticles - chemistry; Molecular Structure; Nanoparticles; Particle Size; Poly(ethylene glycol); Poly(N-isopropylacrylamide); Polymers - chemical synthesis; Polymers - chemistry; Surface Properties; Temperature; Poly(N-isopropylacrylamide); Iron oxide nanoparticles; Doxorubicin; Block copolymer; Poly(ethylene glycol); Apoptosis

[Display omitted] Efficient and controlled delivery of therapeutics to tumor cells is one of the important issues in cancer therapy. In the present work, a series of pH- and temperature-responsive polymer grafted iron oxide nanoparticles were prepared by simple coupling of aminated iron oxide nanopa...