Immunohistochemical and molecular profiles of heterogeneous components of metaplastic breast cancer: a squamous cell carcinomatous component was distinct from a spindle cell carcinomatous component
Metaplastic breast carcinoma (MBC), a category of breast cancer, includes different histological types, which are occasionally mixed and heterogeneous. Considering the heterogeneity of cancer cells in a tumour mass has become highly significant, not only from a biological aspect but also for clinica...
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| Published in | Discover. Oncology Vol. 15; no. 1; pp. 95 - 12 |
|---|---|
| Main Authors | , , , , , , , , |
| Format | Journal Article |
| Language | English |
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New York
Springer US
02.04.2024
Springer Nature B.V Springer |
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| Online Access | Get full text |
| ISSN | 2730-6011 2730-6011 |
| DOI | 10.1007/s12672-024-00950-0 |
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| Abstract | Metaplastic breast carcinoma (MBC), a category of breast cancer, includes different histological types, which are occasionally mixed and heterogeneous. Considering the heterogeneity of cancer cells in a tumour mass has become highly significant, not only from a biological aspect but also for clinical management of recurrence. This study aimed to analyse the immunohistochemical and molecular profiles of each MBC component of a tumour mass. Twenty-five MBC tumours were histologically evaluated, and the most frequent MBC component (c) was squamous cell carcinoma (SCC), followed by spindle cell carcinoma (SpCC). A total of 69 components of MBC and non-MBC in formalin-fixed paraffin-embedded sections were examined for 7 markers by immunohistochemistry. SCC(c) were significantly PTEN negative and CK14 positive, and SpCC(c) were significantly E-cadherin negative and vimentin positive. Multivariate analyses revealed that immunohistochemical profiles of normal/intraductal (IC)(c), no special type (NST)(c), and MBC(c) differed; moreover, SCC(c) and SpCC(c) were distinctly grouped.
PTEN
gene mutation was detected only in SCC(c) (2/7), but not in SpCC(c). Next-generation sequence analyses for 2 cases with tumours containing SCC(c) demonstrated that
PTEN
gene mutation increased progressively from IC(c) to NST(c) to SCC(c). In conclusion, the immunohistochemical and molecular profiles of the SCC(c) of MBC are distinct from those of the SpCC(c). |
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| AbstractList | Metaplastic breast carcinoma (MBC), a category of breast cancer, includes different histological types, which are occasionally mixed and heterogeneous. Considering the heterogeneity of cancer cells in a tumour mass has become highly significant, not only from a biological aspect but also for clinical management of recurrence. This study aimed to analyse the immunohistochemical and molecular profiles of each MBC component of a tumour mass. Twenty-five MBC tumours were histologically evaluated, and the most frequent MBC component (c) was squamous cell carcinoma (SCC), followed by spindle cell carcinoma (SpCC). A total of 69 components of MBC and non-MBC in formalin-fixed paraffin-embedded sections were examined for 7 markers by immunohistochemistry. SCC(c) were significantly PTEN negative and CK14 positive, and SpCC(c) were significantly E-cadherin negative and vimentin positive. Multivariate analyses revealed that immunohistochemical profiles of normal/intraductal (IC)(c), no special type (NST)(c), and MBC(c) differed; moreover, SCC(c) and SpCC(c) were distinctly grouped.
PTEN
gene mutation was detected only in SCC(c) (2/7), but not in SpCC(c). Next-generation sequence analyses for 2 cases with tumours containing SCC(c) demonstrated that
PTEN
gene mutation increased progressively from IC(c) to NST(c) to SCC(c). In conclusion, the immunohistochemical and molecular profiles of the SCC(c) of MBC are distinct from those of the SpCC(c). Metaplastic breast carcinoma (MBC), a category of breast cancer, includes different histological types, which are occasionally mixed and heterogeneous. Considering the heterogeneity of cancer cells in a tumour mass has become highly significant, not only from a biological aspect but also for clinical management of recurrence. This study aimed to analyse the immunohistochemical and molecular profiles of each MBC component of a tumour mass. Twenty-five MBC tumours were histologically evaluated, and the most frequent MBC component (c) was squamous cell carcinoma (SCC), followed by spindle cell carcinoma (SpCC). A total of 69 components of MBC and non-MBC in formalin-fixed paraffin-embedded sections were examined for 7 markers by immunohistochemistry. SCC(c) were significantly PTEN negative and CK14 positive, and SpCC(c) were significantly E-cadherin negative and vimentin positive. Multivariate analyses revealed that immunohistochemical profiles of normal/intraductal (IC)(c), no special type (NST)(c), and MBC(c) differed; moreover, SCC(c) and SpCC(c) were distinctly grouped. PTEN gene mutation was detected only in SCC(c) (2/7), but not in SpCC(c). Next-generation sequence analyses for 2 cases with tumours containing SCC(c) demonstrated that PTEN gene mutation increased progressively from IC(c) to NST(c) to SCC(c). In conclusion, the immunohistochemical and molecular profiles of the SCC(c) of MBC are distinct from those of the SpCC(c). Abstract Metaplastic breast carcinoma (MBC), a category of breast cancer, includes different histological types, which are occasionally mixed and heterogeneous. Considering the heterogeneity of cancer cells in a tumour mass has become highly significant, not only from a biological aspect but also for clinical management of recurrence. This study aimed to analyse the immunohistochemical and molecular profiles of each MBC component of a tumour mass. Twenty-five MBC tumours were histologically evaluated, and the most frequent MBC component (c) was squamous cell carcinoma (SCC), followed by spindle cell carcinoma (SpCC). A total of 69 components of MBC and non-MBC in formalin-fixed paraffin-embedded sections were examined for 7 markers by immunohistochemistry. SCC(c) were significantly PTEN negative and CK14 positive, and SpCC(c) were significantly E-cadherin negative and vimentin positive. Multivariate analyses revealed that immunohistochemical profiles of normal/intraductal (IC)(c), no special type (NST)(c), and MBC(c) differed; moreover, SCC(c) and SpCC(c) were distinctly grouped. PTEN gene mutation was detected only in SCC(c) (2/7), but not in SpCC(c). Next-generation sequence analyses for 2 cases with tumours containing SCC(c) demonstrated that PTEN gene mutation increased progressively from IC(c) to NST(c) to SCC(c). In conclusion, the immunohistochemical and molecular profiles of the SCC(c) of MBC are distinct from those of the SpCC(c). Metaplastic breast carcinoma (MBC), a category of breast cancer, includes different histological types, which are occasionally mixed and heterogeneous. Considering the heterogeneity of cancer cells in a tumour mass has become highly significant, not only from a biological aspect but also for clinical management of recurrence. This study aimed to analyse the immunohistochemical and molecular profiles of each MBC component of a tumour mass. Twenty-five MBC tumours were histologically evaluated, and the most frequent MBC component (c) was squamous cell carcinoma (SCC), followed by spindle cell carcinoma (SpCC). A total of 69 components of MBC and non-MBC in formalin-fixed paraffin-embedded sections were examined for 7 markers by immunohistochemistry. SCC(c) were significantly PTEN negative and CK14 positive, and SpCC(c) were significantly E-cadherin negative and vimentin positive. Multivariate analyses revealed that immunohistochemical profiles of normal/intraductal (IC)(c), no special type (NST)(c), and MBC(c) differed; moreover, SCC(c) and SpCC(c) were distinctly grouped. PTEN gene mutation was detected only in SCC(c) (2/7), but not in SpCC(c). Next-generation sequence analyses for 2 cases with tumours containing SCC(c) demonstrated that PTEN gene mutation increased progressively from IC(c) to NST(c) to SCC(c). In conclusion, the immunohistochemical and molecular profiles of the SCC(c) of MBC are distinct from those of the SpCC(c).Metaplastic breast carcinoma (MBC), a category of breast cancer, includes different histological types, which are occasionally mixed and heterogeneous. Considering the heterogeneity of cancer cells in a tumour mass has become highly significant, not only from a biological aspect but also for clinical management of recurrence. This study aimed to analyse the immunohistochemical and molecular profiles of each MBC component of a tumour mass. Twenty-five MBC tumours were histologically evaluated, and the most frequent MBC component (c) was squamous cell carcinoma (SCC), followed by spindle cell carcinoma (SpCC). A total of 69 components of MBC and non-MBC in formalin-fixed paraffin-embedded sections were examined for 7 markers by immunohistochemistry. SCC(c) were significantly PTEN negative and CK14 positive, and SpCC(c) were significantly E-cadherin negative and vimentin positive. Multivariate analyses revealed that immunohistochemical profiles of normal/intraductal (IC)(c), no special type (NST)(c), and MBC(c) differed; moreover, SCC(c) and SpCC(c) were distinctly grouped. PTEN gene mutation was detected only in SCC(c) (2/7), but not in SpCC(c). Next-generation sequence analyses for 2 cases with tumours containing SCC(c) demonstrated that PTEN gene mutation increased progressively from IC(c) to NST(c) to SCC(c). In conclusion, the immunohistochemical and molecular profiles of the SCC(c) of MBC are distinct from those of the SpCC(c). |
| ArticleNumber | 95 |
| Author | Tanino, Tomoyuki Tang, Xiaoyan Hakamada, Kenichi Nakanishi, Yoko Nishimaki-Watanabe, Haruna Kobayashi, Hiroko Suzuki, Takahiro Ohni, Sumie Masuda, Shinobu |
| Author_xml | – sequence: 1 givenname: Takahiro surname: Suzuki fullname: Suzuki, Takahiro organization: Division of Oncologic Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine, Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine – sequence: 2 givenname: Yoko surname: Nakanishi fullname: Nakanishi, Yoko organization: Division of Oncologic Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine – sequence: 3 givenname: Tomoyuki surname: Tanino fullname: Tanino, Tomoyuki organization: Division of Oncologic Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine – sequence: 4 givenname: Haruna surname: Nishimaki-Watanabe fullname: Nishimaki-Watanabe, Haruna organization: Division of Oncologic Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine – sequence: 5 givenname: Hiroko surname: Kobayashi fullname: Kobayashi, Hiroko organization: Division of Oncologic Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine – sequence: 6 givenname: Sumie surname: Ohni fullname: Ohni, Sumie organization: Division of Oncologic Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine – sequence: 7 givenname: Xiaoyan surname: Tang fullname: Tang, Xiaoyan organization: Division of Oncologic Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine – sequence: 8 givenname: Kenichi surname: Hakamada fullname: Hakamada, Kenichi organization: Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine – sequence: 9 givenname: Shinobu orcidid: 0000-0002-0361-8071 surname: Masuda fullname: Masuda, Shinobu email: masuda.shinobu@nihon-u.ac.jp organization: Division of Oncologic Pathology, Department of Pathology and Microbiology, Nihon University School of Medicine |
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| Keywords | Heterogeneity Squamous cell carcinoma Tensin homologue Metaplastic breast carcinoma Phosphatase Spindle cell carcinoma |
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multi-institutional studyBr J Cancer20151122832891:STN:280:DC%2BC2MzgsFKrtg%3D%3D10.1038/bjc.2014.59225422911 – volume: 28 start-page: 340 year: 2015 ident: 950_CR7 publication-title: Mod Pathol doi: 10.1038/modpathol.2014.142 – volume: 25 start-page: 590 year: 2014 ident: 950_CR16 publication-title: Cancer Cell doi: 10.1016/j.ccr.2014.03.033 – volume: 117 start-page: 273 year: 2009 ident: 950_CR6 publication-title: Breast Cancer Res Treat doi: 10.1007/s10549-008-0197-9 – volume: 61 start-page: 64 year: 2015 ident: 950_CR27 publication-title: Clin Chem doi: 10.1373/clinchem.2014.223040 – volume: 112 start-page: 283 year: 2015 ident: 950_CR3 publication-title: Br J Cancer doi: 10.1038/bjc.2014.592 – volume: 123 start-page: 3628 year: 2017 ident: 950_CR15 publication-title: Cancer doi: 10.1002/cncr.30781 – volume: 26 start-page: 1216 year: 2015 ident: 950_CR22 publication-title: Ann Oncol doi: 10.1093/annonc/mdv109 – volume: 68 start-page: 63 year: 2018 ident: 950_CR29 publication-title: 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| SubjectTerms | Antibodies Breast cancer Cancer Research Cell cycle Connective tissue diseases Cytokeratin Growth factors Heterogeneity Histology Hospitals Internal Medicine Kinases Medical records Medicine Medicine & Public Health Metaplastic breast carcinoma Molecular Medicine Mutation Oncology Phosphatase Radiotherapy Spindle cell carcinoma Squamous cell carcinoma Surgical Oncology Tensin homologue Tumors |
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| Title | Immunohistochemical and molecular profiles of heterogeneous components of metaplastic breast cancer: a squamous cell carcinomatous component was distinct from a spindle cell carcinomatous component |
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