Hippo Signaling Pathway as a Central Mediator of Receptors Tyrosine Kinases (RTKs) in Tumorigenesis

• Published in: Cancers Vol. 12; no. 8; p. 2042
• Main Authors: Azad, Taha, Rezaei, Reza, Surendran, Abera, Singaravelu, Ragunath, Boulton, Stephen, Dave, Jaahnavi, Bell, John C., Ilkow, Carolina S.
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.08.2020; MDPI
• Subjects: 1-Phosphatidylinositol 3-kinase; Apoptosis; Cancer; Carcinogenesis; Cell adhesion & migration; Cell growth; Cell proliferation; Gene expression; Health aspects; Hippo signaling; Kinases; Mammals; MAP kinase; Mutation; Observations; Phosphotransferases; Physiology; Proteins; receptor tyrosine kinases (RTKs); Review; Signal transduction; Stem cells; TAZ; Tumorigenesis; Tyrosine; YAP; Canada

The Hippo pathway plays a critical role in tissue and organ growth under normal physiological conditions, and its dysregulation in malignant growth has made it an attractive target for therapeutic intervention in the fight against cancer. To date, its complex signaling mechanisms have made it diffic...