Effects of whole body heating on dynamic baroreflex regulation of heart rate in humans
Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas 75231; and Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75235 The purpose of this project was to identify whether dynamic baroreflex regulation of heart rate...
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Published in | American journal of physiology. Heart and circulatory physiology Vol. 279; no. 5; pp. H2486 - H2492 |
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Format | Journal Article |
Language | English |
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Abstract | Institute for Exercise and Environmental Medicine, Presbyterian
Hospital of Dallas, Dallas 75231; and Department of Internal
Medicine, University of Texas Southwestern Medical Center, Dallas,
Texas 75235
The purpose of this project was to identify
whether dynamic baroreflex regulation of heart rate (HR) is altered
during whole body heating. In 14 subjects, dynamic baroreflex
regulation of HR was assessed using transfer function analysis. In
normothermic and heat-stressed conditions, each subject breathed at a
fixed rate (0.25 Hz) while beat-by-beat HR and systolic blood pressure (SBP) were obtained. Whole body heating significantly increased sublingual temperature, HR, and forearm skin blood flow. Spectral analysis of HR and SBP revealed that the heat stress significantly reduced HR and SBP variability within the high-frequency range (0.2-0.3 Hz), reduced SBP variability within the low-frequency range (0.03-0.15 Hz), and increased the ratio of low- to
high-frequency HR variability (all P < 0.01). Transfer
function gain analysis showed that the heat stress reduced dynamic
baroreflex regulation of HR within the high-frequency range (from
1.04 ± 0.06 to 0.54 ± 0.6 beats · min 1 · mmHg 1 ;
P < 0.001) without significantly affecting the gain in
the low-frequency range ( P = 0.63). These data suggest
that whole body heating reduced high-frequency dynamic baroreflex
regulation of HR associated with spontaneous changes in blood pressure.
Reduced vagal baroreflex regulation of HR may contribute to reduced
orthostatic tolerance known to occur in humans during heat stress.
baroreceptor; orthostatic intolerance; transfer function analysis; spectral analysis |
---|---|
AbstractList | Institute for Exercise and Environmental Medicine, Presbyterian
Hospital of Dallas, Dallas 75231; and Department of Internal
Medicine, University of Texas Southwestern Medical Center, Dallas,
Texas 75235
The purpose of this project was to identify
whether dynamic baroreflex regulation of heart rate (HR) is altered
during whole body heating. In 14 subjects, dynamic baroreflex
regulation of HR was assessed using transfer function analysis. In
normothermic and heat-stressed conditions, each subject breathed at a
fixed rate (0.25 Hz) while beat-by-beat HR and systolic blood pressure (SBP) were obtained. Whole body heating significantly increased sublingual temperature, HR, and forearm skin blood flow. Spectral analysis of HR and SBP revealed that the heat stress significantly reduced HR and SBP variability within the high-frequency range (0.2-0.3 Hz), reduced SBP variability within the low-frequency range (0.03-0.15 Hz), and increased the ratio of low- to
high-frequency HR variability (all P < 0.01). Transfer
function gain analysis showed that the heat stress reduced dynamic
baroreflex regulation of HR within the high-frequency range (from
1.04 ± 0.06 to 0.54 ± 0.6 beats · min 1 · mmHg 1 ;
P < 0.001) without significantly affecting the gain in
the low-frequency range ( P = 0.63). These data suggest
that whole body heating reduced high-frequency dynamic baroreflex
regulation of HR associated with spontaneous changes in blood pressure.
Reduced vagal baroreflex regulation of HR may contribute to reduced
orthostatic tolerance known to occur in humans during heat stress.
baroreceptor; orthostatic intolerance; transfer function analysis; spectral analysis The purpose of this project was to identify whether dynamic baroreflex regulation of heart rate (HR) is altered during whole body heating. In 14 subjects, dynamic baroreflex regulation of HR was assessed using transfer function analysis. In normothermic and heat-stressed conditions, each subject breathed at a fixed rate (0. 25 Hz) while beat-by-beat HR and systolic blood pressure (SBP) were obtained. Whole body heating significantly increased sublingual temperature, HR, and forearm skin blood flow. Spectral analysis of HR and SBP revealed that the heat stress significantly reduced HR and SBP variability within the high-frequency range (0.2-0.3 Hz), reduced SBP variability within the low-frequency range (0.03-0.15 Hz), and increased the ratio of low- to high-frequency HR variability (all P < 0.01). Transfer function gain analysis showed that the heat stress reduced dynamic baroreflex regulation of HR within the high-frequency range (from 1.04 +/- 0.06 to 0.54 +/- 0.6 beats. min(-1). mmHg(-1); P < 0.001) without significantly affecting the gain in the low-frequency range (P = 0.63). These data suggest that whole body heating reduced high-frequency dynamic baroreflex regulation of HR associated with spontaneous changes in blood pressure. Reduced vagal baroreflex regulation of HR may contribute to reduced orthostatic tolerance known to occur in humans during heat stress. The purpose of this project was to identify whether dynamic baroreflex regulation of heart rate (HR) is altered during whole body heating. In 14 subjects, dynamic baroreflex regulation of HR was assessed using transfer function analysis. In normothermic and heat-stressed conditions, each subject breathed at a fixed rate (0.25 Hz) while beat-by-beat HR and systolic blood pressure (SBP) were obtained. Whole body heating significantly increased sublingual temperature, HR, and forearm skin blood flow. Spectral analysis of HR and SBP revealed that the heat stress significantly reduced HR and SBP variability within the high-frequency range (0.2–0.3 Hz), reduced SBP variability within the low-frequency range (0.03–0.15 Hz), and increased the ratio of low- to high-frequency HR variability (all P < 0.01). Transfer function gain analysis showed that the heat stress reduced dynamic baroreflex regulation of HR within the high-frequency range (from 1.04 ± 0.06 to 0.54 ± 0.6 beats · min −1 · mmHg −1 ; P < 0.001) without significantly affecting the gain in the low-frequency range ( P = 0.63). These data suggest that whole body heating reduced high-frequency dynamic baroreflex regulation of HR associated with spontaneous changes in blood pressure. Reduced vagal baroreflex regulation of HR may contribute to reduced orthostatic tolerance known to occur in humans during heat stress. |
Audience | PUBLIC |
Author | Crandall, C. G Zhang, R Levine, B. D |
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Cites_doi | 10.1161/01.CIR.95.6.1441 10.1161/01.HYP.10.5.538 10.1152/ajpheart.1997.272.2.H776 10.1152/jappl.1984.56.2.441 10.1152/jappl.1990.68.3.1220 10.1161/01.CIR.97.14.1362 10.1161/01.CIR.84.2.482 10.1161/01.RES.59.2.178 10.1007/s004840050042 10.1161/01.RES.51.1.73 10.1152/jappl.1972.33.4.418 10.1152/ajplegacy.1965.209.6.1267 10.1161/01.CIR.96.9.3224 10.1016/S0165-1838(96)00134-8 10.1109/10.8688 10.1152/ajpheart.2000.279.4.H1955 10.1152/ajpheart.1999.277.6.H2348 10.1152/ajpheart.1991.261.4.H1231 10.1152/ajplegacy.1970.218.1.124 10.1152/ajpheart.1997.272.1.H485 10.1152/ajpheart.1985.248.1.H151 10.1152/jappl.1973.35.6.798 10.1126/science.6166045 10.1152/ajpregu.1998.275.3.R844 10.1152/jappl.1968.25.3.268 10.1161/01.CIR.93.8.1527 |
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Snippet | Institute for Exercise and Environmental Medicine, Presbyterian
Hospital of Dallas, Dallas 75231; and Department of Internal
Medicine, University of Texas... The purpose of this project was to identify whether dynamic baroreflex regulation of heart rate (HR) is altered during whole body heating. In 14 subjects,... |
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SubjectTerms | Adult Baroreflex - physiology Blood Flow Velocity - physiology Blood Pressure - physiology Body Temperature - physiology Diastole Female Heart Rate - physiology Hot Temperature Humans Life Sciences (General) Male Respiration Skin - blood supply Skin Temperature - physiology Space life sciences Systole |
Title | Effects of whole body heating on dynamic baroreflex regulation of heart rate in humans |
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