Erythropoietin Stimulates Tumor Growth via EphB4

• Published in: Cancer cell Vol. 28; no. 5; pp. 610 - 622
• Main Authors: Pradeep, Sunila, Huang, Jie, Mora, Edna M., Nick, Alpa M., Cho, Min Soon, Wu, Sherry Y., Noh, Kyunghee, Pecot, Chad V., Rupaimoole, Rajesha, Stein, Martin A., Brock, Stephan, Wen, Yunfei, Xiong, Chiyi, Gharpure, Kshipra, Hansen, Jean M., Nagaraja, Archana S., Previs, Rebecca A., Vivas-Mejia, Pablo, Han, Hee Dong, Hu, Wei, Mangala, Lingegowda S., Zand, Behrouz, Stagg, Loren J., Ladbury, John E., Ozpolat, Bulent, Alpay, S. Neslihan, Nishimura, Masato, Stone, Rebecca L., Matsuo, Koji, Armaiz-Peña, Guillermo N., Dalton, Heather J., Danes, Christopher, Goodman, Blake, Rodriguez-Aguayo, Cristian, Kruger, Carola, Schneider, Armin, Haghpeykar, Shyon, Jaladurgam, Padmavathi, Hung, Mien-Chie, Coleman, Robert L., Liu, Jinsong, Li, Chun, Urbauer, Diana, Lopez-Berestein, Gabriel, Jackson, David B., Sood, Anil K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.11.2015
• Subjects: Adult; Aged; Aged, 80 and over; Animals; Blotting, Western; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cell Line, Tumor; Disease Progression; Erythropoietin - genetics; Erythropoietin - pharmacology; Female; Gene Expression Regulation, Neoplastic - drug effects; Humans; Kaplan-Meier Estimate; MCF-7 Cells; Mice, Inbred C57BL; Mice, Nude; Middle Aged; Ovarian Neoplasms - genetics; Ovarian Neoplasms - metabolism; Ovarian Neoplasms - pathology; Protein Binding - drug effects; Receptor, EphB4 - genetics; Receptor, EphB4 - metabolism; Receptors, Erythropoietin - genetics; Receptors, Erythropoietin - metabolism; Recombinant Proteins - pharmacology; Reverse Transcriptase Polymerase Chain Reaction; STAT3 Transcription Factor - genetics; STAT3 Transcription Factor - metabolism; Young Adult

While recombinant human erythropoietin (rhEpo) has been widely used to treat anemia in cancer patients, concerns about its adverse effects on patient survival have emerged. A lack of correlation between expression of the canonical EpoR and rhEpo’s effects on cancer cells prompted us to consider the...