Molecular convergence of neutralizing antibodies in human revealed by repeated rabies vaccination

• Published in: npj vaccines Vol. 10; no. 1; pp. 39 - 14
• Main Authors: Fujisawa, Mizuki, Onodera, Taishi, Kuroda, Daisuke, Kewcharoenwong, Chidchamai, Sasaki, Michihito, Itakura, Yukari, Yumoto, Kohei, Nithichanon, Arnone, Ito, Naoto, Takeoka, Shinji, Suzuki, Tadaki, Sawa, Hirofumi, Lertmemongkolchai, Ganjana, Takahashi, Yoshimasa
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.02.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/2152/2153/1291; 631/250/590/1883; Antigens; Bats; Biomedical and Life Sciences; Biomedicine; Immunization; Infectious Diseases; Medical Microbiology; Monoclonal antibodies; Proteins; Public Health; R&D; Rabies; Research & development; RNA polymerase; Science; Vaccine; Vaccines; Virology; Zoonoses

Rabies vaccines require repeated immunization to robustly elicit neutralizing antibodies that prevent fatal diseases. Here, we analyzed rabies glycoprotein antibody repertoires at both polyclonal and monoclonal levels following repeated vaccination. Booster vaccination dramatically elevated the neut...