Identification of potential LncRNAs as papillary thyroid carcinoma biomarkers based on integrated bioinformatics analysis using TCGA and RNA sequencing data

• Published in: Scientific reports Vol. 13; no. 1; p. 4350
• Main Authors: Feng, Jia-Lin, Zheng, Wen-Jie, Xu, Le, Zhou, Qin-Yi, Chen, Jun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.03.2023; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114; 631/67; Bioinformatics; Biomarkers; Gene Expression Regulation, Neoplastic; Genes; Genomes; Humanities and Social Sciences; Humans; Lymph nodes; Metastases; multidisciplinary; Non-coding RNA; Papillary thyroid cancer; Papillary thyroid carcinoma; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Science; Science (multidisciplinary); Sequence Analysis, RNA; Thyroid; Thyroid cancer; Thyroid Cancer, Papillary - diagnosis; Thyroid Cancer, Papillary - genetics; Thyroid Cancer, Papillary - pathology; Thyroid Neoplasms - diagnosis; Thyroid Neoplasms - genetics; Thyroid Neoplasms - pathology

The roles and mechanisms of long non-coding RNAs (lncRNAs) in papillary thyroid cancer (PTC) remain elusive. We obtained RNA sequencing (RNA-seq) data of surgical PTC specimens from patients with thyroid cancer (THCA; n = 20) and identified differentially expressed genes (DEGs) between cancer and ca...