Deciphering the role of protein kinase A in the control of FoxP3 expression in regulatory T cells in health and autoimmunity

• Published in: Scientific reports Vol. 14; no. 1; pp. 17571 - 11
• Main Authors: Lepore, Maria Teresa, Bruzzaniti, Sara, La Rocca, Claudia, Fusco, Clorinda, Carbone, Fortunata, Mottola, Maria, Zuccarelli, Bruno, Lanzillo, Roberta, Brescia Morra, Vincenzo, Maniscalco, Giorgia Teresa, De Simone, Salvatore, Procaccini, Claudio, Porcellini, Antonio, De Rosa, Veronica, Galgani, Mario, Cassano, Silvana, Matarese, Giuseppe
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.07.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 631/250/38; 692/699/375; Autoimmunity; CD25 antigen; CD4 antigen; Cyclic AMP response element-binding protein; Cyclic AMP Response Element-Binding Protein - metabolism; Cyclic AMP-Dependent Protein Kinases - metabolism; Female; Forkhead protein; Forkhead Transcription Factors - genetics; Forkhead Transcription Factors - metabolism; Foxp3 protein; Gene Expression Regulation; Humanities and Social Sciences; Humans; Immunoregulation; Kinases; Lymphocytes T; Male; Molecular modelling; multidisciplinary; Multiple sclerosis; Multiple Sclerosis - immunology; Multiple Sclerosis - metabolism; Phosphorylation; Protein kinase A; Proteins; Science; Science (multidisciplinary); T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism

The molecular mechanisms that govern differential T cell development from CD4 + CD25 - conventional T (Tconv) into CD4 + CD25 + forkhead-box-P3 + (FoxP3 + ) inducible regulatory T (iTreg) cells remain unclear. Herein, we investigated the relative contribution of protein kinase A (PKA) in this proces...