Predicting disease progression from the rate of bodyweight change in nasopharyngeal carcinoma patient during radiotherapy

• Published in: Scientific reports Vol. 15; no. 1; pp. 7490 - 12
• Main Authors: Sun, Jiachen, Lam, Sai kit Edmond, Teng, Xinzhi, Zhang, Jiang, Lee, Francis Kar-ho, Yip, Celia Wai-yi, Chow, James Chung-hang, Lee, Victor Ho-fun, Sun, Ying, Cai, Jing
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 03.03.2025; Nature Publishing Group; Nature Portfolio
• Subjects: 631/114/1305; 631/553/2701; 631/67/1536; 692/53/2422; 692/53/2423; Adjuvant chemotherapy; Adult; Aged; Body height; Body Weight - radiation effects; Chemotherapy; Concurrent chemoradiotherapy; Deep learning; Differential equations; Disease Progression; Female; Humanities and Social Sciences; Humans; Male; Middle Aged; multidisciplinary; Multivariate analysis; Nasopharyngeal carcinoma; Nasopharyngeal Carcinoma - pathology; Nasopharyngeal Carcinoma - radiotherapy; Nasopharyngeal Neoplasms - pathology; Nasopharyngeal Neoplasms - radiotherapy; Patients; Prognosis; Radiation therapy; Retrospective Studies; Science; Science (multidisciplinary); Throat cancer; Weight loss; Weight Loss - radiation effects; Nasopharyngeal carcinoma; Deep learning; Adjuvant chemotherapy; Concurrent chemoradiotherapy; Weight loss; Differential equations

Bodyweight loss is a common occurrence in Nasopharyngeal Carcinoma (NPC) patients during Radiotherapy (RT). Previous studies found that the prognostic value of percentage weight loss (pWL) during RT is not credible. We aimed to develop a novel progression predictor surrogated to pWL by modelling all...