Nickel absorption and kinetics in human volunteers

• Published in: Proceedings of the Society for Experimental Biology and Medicine Vol. 191; no. 1; p. 5
• Main Authors: Sunderman, Jr, F W, Hopfer, S M, Sweeney, K R, Marcus, A H, Most, B M, Creason, J
• Format: Journal Article
• Language: English
• Published: United States 01.05.1989
• Subjects: Adult; Biological Availability; Feces - analysis; Female; Food; Humans; Kidney - metabolism; Kinetics; Male; Middle Aged; Nickel - administration & dosage; Nickel - pharmacokinetics; Reference Values; Spectrophotometry, Atomic; Water

Mathematical modeling of the kinetics of nickel absorption, distribution, and elimination was performed in healthy human volunteers who ingested NiSO4 drinking water (Experiment 1) or added to food (Experiment 2). Nickel was analyzed by electrothermal atomic absorption spectrophotometry in serum, ur...