Apolipoprotein E genotyping in women with recurrent pregnancy loss: An in silico and experimental hybrid study

• Published in: Gene Vol. 549; no. 2; pp. 209 - 213
• Main Authors: Poursadegh Zonouzi, Ahmad, Farajzadeh, Davoud, Bargahi, Nasrin, Farajzadeh, Malak
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 10.10.2014
• Subjects: abortion (animals); Abortion, Habitual - epidemiology; Abortion, Habitual - genetics; Adult; alleles; Amino Acid Substitution; Apo E ε4 carriers; Apolipoprotein E; Apolipoproteins E - genetics; Case-Control Studies; codons; Computational Biology; computer software; DNA; Female; Gene Frequency; Genotype; genotyping; Genotyping Techniques; Humans; Iran - epidemiology; pathogenesis; phenotype; polymerase chain reaction; Polymerase Chain Reaction - methods; Polymorphism, Restriction Fragment Length; PolyPhen-2; Pregnancy; Recurrent pregnancy loss; single nucleotide polymorphism; women; Young Adult; Iran; PolyPhen; OR; Apolipoprotein E; Recurrent pregnancy loss; CI; Apo E ε4 carriers; Apo E; RPL; PolyPhen-2

The role of apolipoprotein E gene polymorphisms in the pathogenesis of recurrent pregnancy loss remains controversial. Therefore, our objective was to investigate the association between recurrent pregnancy loss and apolipoprotein E gene polymorphisms among northwest Iranian women, and also to predi...